| Shakespeare Patrol Ltd | Administrative & support | 2025 |
| Shakespeare Removals Ltd | Transport & logistics | 2025 |
| Shakespeare Storage Ltd | Real estate | 2025 |
| Shakespeare Treasure Ltd | Administrative & support | 2025 |
| Shales Press Maintenance Ltd | Professional & scientific | 2024 |
| Shali Wellbeing CIC | Education | 2024 |
| Shamdy Holdings Limited | Financial services | 2026 |
| Shanghavi & Company Limited | Other services | 2024 |
| Shannonside Civil Engineering Limited | Construction | 2004 |
| Shannonside Holdings Limited | Construction | 2015 |
| Shape Cosmetic Clinic Ltd | Health & social care | 2019 |
| Sharp Collective Ltd | Information & communication | 2025 |
| Sharp Images Ltd | Professional & scientific | 2008 |
| Shaun Pritchard Services Limited | Transport & logistics | 2016 |
| Shawcross Construction Ltd | Wholesale & retail | 2004 |
| SHB Games Limited | Information & communication | 2023 |
| Sheepbridge Engineering Limited | | 1948 |
| Shellam Transport Services Ltd | Transport & logistics | 2019 |
| Shepard Consulting Ltd | Professional & scientific | 2017 |
| Shepdale Holdings Limited | Real estate | 2020 |
| Shepley Grange Management Company Limited | Real estate | 1997 |
| Shield Services Solutions Limited | Health & social care | 2025 |
| Shift Graphics Limited | Manufacturing | 2021 |
| Shifted 6 Ltd | Extraterritorial | 2019 |
| Shine on Services Limited | Administrative & support | 2025 |
| Shineplus Elite Cleaning Ltd | Administrative & support | 2025 |
| Shire Products Limited | Administrative & support | 2004 |
| Shire Taverns Ltd | Hospitality | 2018 |
| Shire Wood Fuel Limited | Manufacturing | 2004 |
| Shires Multi Academy Trust | Education | 2011 |
| Shopwright Ltd | Wholesale & retail | 2003 |
| Shoulderbroad Holdings Ltd | Financial services | 2024 |
| Show ME YOU Care Ltd | Health & social care | 2026 |
| Shower Installations Ltd | Construction | 2016 |
| SHP Properties Ltd | Real estate | 2016 |
| Shurnock Court Barns Management Company Limited | Real estate | 1997 |
| Shurnock Equine Limited | Administrative & support | 2024 |
| Shush Marketing Ltd | Professional & scientific | 2023 |
| Shuvl Bikes Limited | Manufacturing | 2022 |
| SIA Carpentry Limited | Manufacturing | 2022 |
| Sialtek Ltd | Wholesale & retail | 2025 |
| Sicca Therapeutics Limited | Professional & scientific | 2022 |
| Sid's Barbers Ltd | Other services | 2020 |
| Sidewinder Limited | Professional & scientific | 2011 |
| Sierra Management Ltd | Information & communication | 2025 |
| Sigma Industries Limited | Manufacturing | 1981 |
| Sign Solutions (Sign Language Interpreting Agency) Ltd | Professional & scientific | 2003 |
| Sign Specialists Limited | Manufacturing | 1961 |
| Sign, Metals & Plastics Limited | Manufacturing | 1992 |
| Silver Wing Film Studios Ltd | Information & communication | 2025 |
| Silverback Commercial Law Services Limited | Professional & scientific | 2014 |
| Silvesters Holdings Limited | Construction | 2006 |
| SIM Zone Ltd | Extraterritorial | 2014 |
| Simperium Ltd | Professional & scientific | 2019 |
| Simplex Transport Ltd | Transport & logistics | 2024 |
| Simplidata Ltd | Information & communication | 2016 |
| Simply Doors and Windows Ltd | Construction | 2020 |
| Simply JP Limited | Administrative & support | 2014 |
| Simply Massage Ltd | Health & social care | 2018 |
| Simpology Solutions Limited | Information & communication | 2015 |
| Sims ST Ltd | Wholesale & retail | 2025 |
| Simven Containers Limited | Manufacturing | 1979 |
| Siren Hair Art Group Limited | Administrative & support | 2021 |
| Sister Styles Midlands Limited | Wholesale & retail | 2026 |
| Sisyphus Properties (1) Ltd | Other services | 2011 |
| Sisyphus Properties (2) Ltd | Real estate | 2014 |
| Sitetec Management Services Ltd | Professional & scientific | 2012 |
| SJC Heating & Plumbing Ltd | Construction | 2020 |
| SJD Enterprises Limited | Professional & scientific | 2007 |
| SJF Group Ltd | Agriculture & fishing | 2025 |
| SJL & Co Accounting Ltd | Professional & scientific | 2019 |
| Sjmg Holdings Ltd | Financial services | 2016 |
| Sjpr Digital Asset Solutions Ltd | Financial services | 2023 |
| SJR Document Management Ltd | Transport & logistics | 2020 |
| SJT Accounting Services Limited | Professional & scientific | 2018 |
| SK Gold Ltd | Wholesale & retail | 2026 |
| SK Gosal Ltd | Wholesale & retail | 2024 |
| SKD Events Ltd | Information & communication | 2023 |
| SKD Rentals Limited | Real estate | 2022 |
| Sketch Decorum Limited | Arts & recreation | 2018 |
| Skidsters Limited | Manufacturing | 2012 |
| Skilts Farm Stables Limited | Arts & recreation | 2002 |
| Skipp Plant Services Ltd. | Manufacturing | 2022 |
| Skua Racing Limited | Wholesale & retail | 2022 |
| Sky Visor Limited | Manufacturing | 2017 |
| Skyforge Roofing Ltd | Construction | 2025 |
| Skylifter Ltd | Administrative & support | 2018 |
| Skyline Logistics Limited | Transport & logistics | 2001 |
| Skywise Roofing Limited | Construction | 2024 |
| Slay IT B Limited | Wholesale & retail | 2026 |
| SLC Veterinary Services Ltd | Professional & scientific | 2019 |
| SLE International Ltd | Information & communication | 2008 |
| Slimstock Limited | Information & communication | 2006 |
| Slinky Properties Ltd | Real estate | 2020 |
| Slm-Ai Solutions Ltd | Information & communication | 2026 |
| SLP Estates Limited | Real estate | 2025 |
| SLS Utilities Limited | Construction | 2014 |
| SM Executive Marketing Limited | Professional & scientific | 2019 |
| SM Pro Wheels Limited | Wholesale & retail | 2014 |
| Smaki ANI Redditch Ltd | Manufacturing | 2026 |