| S.F.S. Joinery & Fire Services Ltd | Construction | 2022 |
| S.F.Theatre Scrub Services Limited | Health & social care | 2015 |
| S.H.Patterns & Castings Limited | Administrative & support | 2010 |
| S44 Limited | Professional & scientific | 2012 |
| SA Leather Jackets Ltd | Wholesale & retail | 2019 |
| SA Walsh Consultancy Ltd | Health & social care | 2019 |
| Sabarigiri Limited | Health & social care | 2015 |
| Saenger Consultants Limited | Professional & scientific | 2008 |
| Safaco Ltd | Wholesale & retail | 2026 |
| Safe Skin Ltd | Wholesale & retail | 2022 |
| Safetyology Consultancy Ltd | Professional & scientific | 2022 |
| Sage Designs Limited | Professional & scientific | 1989 |
| Salaar Logistics Ltd | Transport & logistics | 2025 |
| Salamander Security Group Limited | Administrative & support | 2026 |
| Salcomotive Services Limited | Administrative & support | 2012 |
| Salter Capital Limited | Financial services | 2025 |
| Saltley Limited | Health & social care | 1997 |
| Saltway Investment Ltd | Real estate | 2024 |
| Salus Management Services Ltd | Professional & scientific | 2021 |
| Salutivia Limited | Extraterritorial | 2013 |
| SAM Access Ltd | Professional & scientific | 2010 |
| SAM Bridgman Ltd | Administrative & support | 2019 |
| Sam&Ace Logistics Ltd | Transport & logistics | 2025 |
| Sambourne Lane Farm Management Company Limited | Real estate | 2021 |
| Samuel Taylor Group Limited | Professional & scientific | 2013 |
| San-An Clothing Limited | Wholesale & retail | 2022 |
| Sangre Engineering & Management Services Ltd | Manufacturing | 2005 |
| Sangre Engineering and Design Ltd | Professional & scientific | 2017 |
| Sangre Environmental Services Limited | Professional & scientific | 1985 |
| Sanitare Bathrooms and Kitchens Limited | Construction | 2003 |
| Santosha Soul Limited | Other services | 2022 |
| Saoirse O'Connell Ltd | Energy | 2020 |
| SAP Green Consultancy Ltd | Health & social care | 2020 |
| Sapling Joinery Ltd | Manufacturing | 2024 |
| Sardcorp Sciences Ltd | Professional & scientific | 2011 |
| SAS Accountant Ltd | Professional & scientific | 2016 |
| SAS Cookham Limited | Hospitality | 2019 |
| Satnam Rana Ltd | Arts & recreation | 2023 |
| Satynam Limited | Extraterritorial | 2009 |
| Saureland Ltd | Transport & logistics | 2019 |
| Saveonmy.Com Limited | Financial services | 2022 |
| Sawmaster Ltd | Wholesale & retail | 2019 |
| SAY IT With Thread Limited | Manufacturing | 2025 |
| Sayers Electrical Ltd | Construction | 2019 |
| SB Fabrication's Ltd | Manufacturing | 2020 |
| SB Property Development & SON Ltd | Construction | 2020 |
| SB Property Holdings Ltd | Real estate | 2024 |
| SBC (Redditch) Ltd | Hospitality | 2017 |
| SBR Inventory Services Ltd | Other services | 2025 |
| Scad (Warwickshire) Ltd | Professional & scientific | 2012 |
| SCG Services Group Limited | Administrative & support | 2009 |
| Schofield Gardening Limited | Administrative & support | 2015 |
| Schooldays Limited | Manufacturing | 2024 |
| SCL Recruitment Services Ltd | Administrative & support | 2020 |
| Scott's of Worcester Ltd | Hospitality | 2018 |
| Scroll and Buy Limited | Wholesale & retail | 2025 |
| Scrubba DUB Dogs Ltd | Other services | 2026 |
| Scuba Arena Holdings Ltd | Financial services | 2022 |
| Sculpt a Scape Ltd | Administrative & support | 2019 |
| SDM Print & Business Services Limited | Manufacturing | 2009 |
| Sea Farms Limited | Wholesale & retail | 2011 |
| Sea Farms Nutrition Limited | Agriculture & fishing | 2016 |
| Seafield Assets Limited | Professional & scientific | 2025 |
| Seafresh Group (Holdings) Limited | Manufacturing | 2011 |
| Search Environmental Limited | Professional & scientific | 2004 |
| Season Coffee Limited | Hospitality | 2024 |
| Sebright Creative Limited | Professional & scientific | 2014 |
| Secproject Ltd | Information & communication | 2023 |
| Security Safe Services Limited | Extraterritorial | 2012 |
| Seedbed Studio Limited | Education | 2020 |
| Sefac UK Limited | Manufacturing | 2006 |
| Select Engineering (UK) Limited | Manufacturing | 2002 |
| Select Specialist Cars Ltd | Wholesale & retail | 2025 |
| Selene Health Limited | Health & social care | 2025 |
| Self Storage Worcestershire Limited | Transport & logistics | 2021 |
| Selina LIM Ltd | Information & communication | 2024 |
| Sely Limited | Real estate | 2022 |
| Serpentine Fuels Limited | Wholesale & retail | 2023 |
| Servezi Ltd | Hospitality | 2025 |
| Service Express Lettings Limited | Hospitality | 2020 |
| Servicom (High Tech) Limited | Information & communication | 1989 |
| Seven Stars (Redditch) Ltd | Hospitality | 2024 |
| Severn Electrical Ltd | Construction | 2019 |
| Severn Lease Ltd | Administrative & support | 2024 |
| Severn Letting Ltd | Hospitality | 2021 |
| Severn Valley Solutions Limited | Wholesale & retail | 2012 |
| Severndale Ltd | Financial services | 2025 |
| Seymour Financial Ltd | Financial services | 2018 |
| Seymour Road Management Co Limited | Real estate | 1998 |
| Seyon Housing LLC Limited | Real estate | 2023 |
| SG Roofing Limited | Construction | 2021 |
| SG Springs Limited | Manufacturing | 2014 |
| Sghs Ltd | Construction | 2022 |
| SH Diesel Repair Centre UK Ltd | Wholesale & retail | 2017 |
| Sh&Cp Limited | Financial services | 2025 |
| Shabih Property Ltd | Real estate | 2024 |
| Shadowpulse ORG Ltd | Information & communication | 2025 |
| Shaibi-Webb Group Ltd | Construction | 2026 |
| Shaker (UK) Limited | Hospitality | 2002 |
| Shakespeare Packaging Ltd | Administrative & support | 2021 |