| Soneh Medical Ltd | Health & social care | 2015 |
| Soneh Property and Investments Limited | Real estate | 2024 |
| Sonexa Media Ltd | Information & communication | 2011 |
| Soulscented Limited | Manufacturing | 2022 |
| Soundhound Ltd | Wholesale & retail | 2024 |
| Sovereign Box Ltd | Wholesale & retail | 2025 |
| Spanish Outlet Ltd | Wholesale & retail | 2014 |
| Spark Electrical Contractors Ltd | Construction | 2018 |
| Spatial Co-Ord Construction Ltd | Administrative & support | 2025 |
| Specialized Flooring Limited | Construction | 1976 |
| Speech Matters Speech Therapy Ltd | Health & social care | 2021 |
| Sporting Futures Ltd | Arts & recreation | 2022 |
| Spotspan Property Management Limited | Households | 1990 |
| SR Restaurant Wirral Ltd | Hospitality | 2020 |
| SSB Logistics Consulting Ltd | Professional & scientific | 2025 |
| ST Demolition and Groundwork Ltd | Construction | 2019 |
| ST. David's Lane Limited | Administrative & support | 2010 |
| ST. Davids House Ltd | Manufacturing | 2025 |
| Staison Ltd | Manufacturing | 2025 |
| Stamped a LOT Ltd | Wholesale & retail | 2019 |
| Starworx Limited | Arts & recreation | 2014 |
| Statham Road 1958 Limited | Extraterritorial | 2014 |
| Stein Properties Limited | Real estate | 2021 |
| Stirling Offshore Services Ltd | Construction | 2023 |
| Stone Masonry Wirral Limited | Construction | 2013 |
| Stratton Oakmont Cleaning Services Limited | Construction | 2021 |
| Stronghold Projects Ltd | Construction | 2025 |
| Style Joinery (Chester) Ltd | Manufacturing | 2024 |
| Sumo Optimus Ltd | Information & communication | 2018 |
| Supporting Souls Ltd | Health & social care | 2020 |
| Surrenda-Link (Investors) Limited | Professional & scientific | 2004 |
| Surrenda-Link Mortgage Holdings Limited | Professional & scientific | 2004 |
| SVJ Rentals Ltd | Real estate | 2025 |
| Swift AID Medical Services Limited | Education | 2026 |
| Swot's-Cleaning Ltd | Administrative & support | 2025 |
| SYJ Solutions Ltd | Information & communication | 2015 |
| T J & Sons Limited | Wholesale & retail | 2013 |
| T Rahman Ltd | Health & social care | 2010 |
| T&Cm Limited | Health & social care | 2023 |
| T'Lec Electrical Services Ltd. | Construction | 2013 |
| TA Innovations Ltd | Wholesale & retail | 2023 |
| Tadpatri Holdings Limited | Administrative & support | 2021 |
| TAG ME Events UK Limited | Hospitality | 2025 |
| Tailspin Limited | Information & communication | 2005 |
| Talentglo Ltd | Information & communication | 2024 |
| Tauk Publishing Limited | Information & communication | 2022 |
| Taylor-Meeks Limited | Hospitality | 2024 |
| Team Draw UK Ltd | Arts & recreation | 2025 |
| Tech@Home Ltd. | Information & communication | 2017 |
| Technical Consultancy Services Ltd. | Manufacturing | 2016 |
| Technology Disposal Limited | Other services | 2025 |
| Teknomek Engineering Ltd | Manufacturing | 2024 |
| Testing Ltd | Construction | 2022 |
| THE Anfield Connect Limited | Administrative & support | 2023 |
| THE Avenue 168 Ltd | Hospitality | 2024 |
| THE Badlands Collective Ltd | Arts & recreation | 2018 |
| THE Clean Club Ltd | Administrative & support | 2024 |
| THE Dance Wardrobe Limited | Wholesale & retail | 2024 |
| THE Dataqube Limited | Professional & scientific | 2010 |
| THE Deep Space Ltd | Wholesale & retail | 2025 |
| THE DYE Works Oxton Limited | Households | 2004 |
| THE General Design Practice Ltd | Professional & scientific | 2025 |
| THE Graceheart Manor Ltd | Health & social care | 2025 |
| THE Happy Synapse Company Limited | Health & social care | 2025 |
| THE Housing Factory Ltd | Administrative & support | 2017 |
| THE Karin Collective Ltd | Professional & scientific | 2026 |
| THE Lone Welder Ltd | Manufacturing | 2025 |
| THE Meadows Development Investment Company Limited | Construction | 1991 |
| THE Midnight Zone Ltd | Professional & scientific | 2024 |
| THE Movement Design Bureau Limited | Professional & scientific | 2005 |
| THE Perfect Time IS NOW Ltd | Professional & scientific | 2020 |
| THE Pyjama Factory Commercial Properties Ltd | Real estate | 2020 |
| THE Pyjama Factory Ltd | Wholesale & retail | 2013 |
| THE Sewing Team Ltd | Manufacturing | 2013 |
| THE Sleeping Beauties Method Limited | Education | 2026 |
| THE Subject Ltd | Financial services | 2022 |
| THE Writer's CUP Ltd | Hospitality | 2024 |
| Theoc Software Limited | Information & communication | 2018 |
| Thermopylae Court Property Management Company Limited | Households | 1976 |
| Tierney Commercial Brokers Limited | Financial services | 2013 |
| Tilly’S Travel Ltd | Transport & logistics | 2025 |
| TIMETRAVEL4U.COM Limited | Other services | 2017 |
| TJV Curtis Limited | Professional & scientific | 2016 |
| TL Mortgage Consultancy Ltd | Real estate | 2019 |
| TMH Contracting Ltd | Manufacturing | 2024 |
| Token Events Ltd | Extraterritorial | 2020 |
| TOM Routly Health and Fitness Limited | Arts & recreation | 2016 |
| Tony Winter Paving Ltd | Construction | 2023 |
| Tooth and Nail Theatre Company Ltd | Arts & recreation | 2018 |
| Top Dog Groomers Limited | Other services | 2012 |
| Total Landscape Care (NW) Ltd | Administrative & support | 2022 |
| Trenchless Rehabilitation Techniques Limited | Construction | 2024 |
| Trim Technik Limited | Manufacturing | 1995 |
| TTT Entertainment Ltd | Hospitality | 2023 |
| Turnesc Tax Limited | Professional & scientific | 2023 |
| Turngreen Limited | Extraterritorial | 1998 |
| TW Training Services Ltd | Public administration | 2022 |
| Twenty Sixteen Limited | Hospitality | 2022 |
| Twinsa&B Limited | Health & social care | 2019 |
| Tyreswirral Ltd | Wholesale & retail | 2020 |