| Ubique Energy & Civils Ltd | Construction | 2023 |
| UK Right to Work Share Code API Ltd | Information & communication | 2024 |
| UK Roofcare Ltd | Construction | 2025 |
| Ultrashiang Limited | Health & social care | 2013 |
| Unbroken Performance Ltd | Arts & recreation | 2021 |
| Underwear Essentials Ltd | Wholesale & retail | 2025 |
| Unique Creations Ltd | Wholesale & retail | 2025 |
| Unite Salon Ltd | Other services | 2023 |
| Update Property Ltd | Real estate | 2022 |
| Upper Parkbury Limited | Households | 1973 |
| US Joinery Ltd | Manufacturing | 2025 |
| Utopia Spaces Ltd | Construction | 2019 |
| Vantage Collective Ltd | Professional & scientific | 2026 |
| Vector Consumer (AUS) Ltd | Manufacturing | 2024 |
| Vector Consumer (NZ) Ltd | Manufacturing | 2024 |
| Vector Consumer (USA) Ltd | Manufacturing | 2024 |
| Vector Consumer Limited | Manufacturing | 2020 |
| Vehiclesearch Limited | Information & communication | 2016 |
| Veletaris Ltd | Professional & scientific | 2025 |
| Veluxa Ltd | Wholesale & retail | 2026 |
| Venator Properties Ltd | Construction | 2023 |
| Veritas Construction Management Ltd | Construction | 2025 |
| Veritas Legal Consulting Limited | Professional & scientific | 2026 |
| Veritis Ltd | Professional & scientific | 2013 |
| Vineyard Commodity Consulting Ltd | Information & communication | 2013 |
| Vintage Radio Ltd | Information & communication | 2023 |
| VR Learning LAB Limited | Education | 2025 |
| Vyner Croft Estate Management Co Ltd | Households | 2018 |
| W.F. Parker Heating Limited | Construction | 2003 |
| Walking Therapy Limited | Education | 2021 |
| Walsh Engineering (Northern) Limited | Construction | 2002 |
| Warriors Pentathlon & Athletic Club Ltd | Arts & recreation | 2022 |
| WE Will Ltd | Professional & scientific | 2023 |
| Webpoint Estates Ltd | Real estate | 2016 |
| Welcome to Work Ltd | Information & communication | 2024 |
| West Kirby Windows Ltd | Wholesale & retail | 2025 |
| West Road (Prenton) Management Limited | Real estate | 2021 |
| What WE DID Next CIC | Arts & recreation | 2013 |
| Wheatout Limited | Hospitality | 2018 |
| Wheels Extreme C.I.C. | Arts & recreation | 2015 |
| White Events Ltd | Arts & recreation | 2017 |
| White Interiors Limited | Wholesale & retail | 2019 |
| Whitewall Construction Limited | Construction | 2009 |
| Wiggins Holdings NW Ltd | Real estate | 2016 |
| Wiise Makeup Ltd | Wholesale & retail | 2025 |
| Willis Accountancy Solutions Ltd | Professional & scientific | 2016 |
| Willow Way Home Ltd | Health & social care | 2025 |
| Windrush Management Limited | Real estate | 2021 |
| Wirral Automotive Services Limited | Wholesale & retail | 2019 |
| Wirral Care Foundation Limited | Health & social care | 2012 |
| Wirral Care Services Limited | Health & social care | 2006 |
| Wirral Carpet Cleaning Limited | Administrative & support | 2017 |
| Wirral Elite Landscaping Ltd | Administrative & support | 2025 |
| Wirral Gymnastics Club CIC | Arts & recreation | 2019 |
| Wirral Lifestart Living Services Limited | Health & social care | 2019 |
| Wirral Makefest C.I.C. | Professional & scientific | 2024 |
| Wirral Mobile Phones Ltd | Other services | 2018 |
| Wirral Montessori Ltd | Health & social care | 2016 |
| Wirral Projects (Design Renovation & Development) Ltd. | Construction | 2024 |
| Wirral Property Management and Maintenance Limited | Construction | 2019 |
| Wirral Roofcare Holdings Limited | Construction | 2024 |
| Wirral Roofcare Limited | Construction | 1982 |
| Wirral Schools FA | Education | 2013 |
| Wirral Worktops Ltd | Manufacturing | 2022 |
| Witchy Wags Ltd | Wholesale & retail | 2024 |
| WNG.D7 Limited | Extraterritorial | 2011 |
| Wockenforth & Co. Ltd | Other services | 2023 |
| Wolf Mountain Properties Ltd | Administrative & support | 2018 |
| Word and Spirit Embassy Ltd | Other services | 2024 |
| Yane and Olga Property Ltd | Real estate | 2026 |
| Yati Limited | Health & social care | 2019 |
| Yellow Firefly Company Limited | Wholesale & retail | 2025 |
| Yomata UK Ltd | Wholesale & retail | 2025 |
| Your Team Sports Ltd | Information & communication | 2023 |
| YYC Kitchen Ltd | Hospitality | 2025 |
| Zafran Property Ltd | Real estate | 2025 |
| Zeko Baba Ltd | Hospitality | 2023 |
| Zendo Golf Ltd | Wholesale & retail | 2026 |
| Zion & Galaxy Ltd | Health & social care | 2017 |