| Print Logic Reprographics Ltd | Manufacturing | 2011 |
| Prmc Consultancy Limited | Information & communication | 2015 |
| Pro Guard UK Ltd | Manufacturing | 2020 |
| Promo Retail Limited | Administrative & support | 2021 |
| Prosper Care Services (NW) Ltd | Health & social care | 2024 |
| Prpv Limited | Professional & scientific | 2022 |
| PRS72 Management Company Limited | Real estate | 2010 |
| PT Security Limited | Administrative & support | 2013 |
| Puviro Investment Ltd | Real estate | 2021 |
| Quay PV Ltd | Construction | 2025 |
| R a C Pallets Liverpool Limited | Water & waste | 2018 |
| R J Wilson & Sons Ltd | Construction | 2023 |
| RA44 Ltd | Hospitality | 2025 |
| Ragnarok Climbing Ltd | Arts & recreation | 2025 |
| Rajakulathu Ltd | Health & social care | 2024 |
| Ravencragg Limited | Extraterritorial | 1978 |
| Real Estate 28 Ltd | Real estate | 2019 |
| Red Union Film Five Limited | Information & communication | 2014 |
| Red Union Film SIX Limited | Information & communication | 2026 |
| Red Union Film Three Ltd | Information & communication | 2009 |
| Red Union Films Development a Ltd | Information & communication | 2015 |
| Red Union Films Limited | Information & communication | 2010 |
| Redcourt Management (North West) Limited | Households | 2022 |
| Reel to Real CIC | Information & communication | 2023 |
| Release Hub Ltd | Information & communication | 2025 |
| Remedy VET Limited | Professional & scientific | 2025 |
| Renewables Lifting Services Ltd | Construction | 2024 |
| Rentoncrest Limited | Households | 1991 |
| Renuntiabo Limited | Agriculture & fishing | 2006 |
| Reproductive Health for ALL | Extraterritorial | 2010 |
| Repti-Verse Ltd | Wholesale & retail | 2023 |
| Required Studios Ltd | Information & communication | 2021 |
| Revive Luxe Limited | Other services | 2023 |
| Rick Skelton Ltd | Information & communication | 2025 |
| Rigby's Mini Travel Ltd | Transport & logistics | 2017 |
| Ringwood Court Limited | Extraterritorial | 2009 |
| RJB Estates Ltd | Real estate | 2022 |
| RJD Insight Ltd | Professional & scientific | 2023 |
| RKQ Engineering Ltd | Information & communication | 2003 |
| RM Product Supply Ltd | Wholesale & retail | 2024 |
| RMJ Mortgage & Life Services Ltd | Financial services | 2021 |
| ROB Palmer Limited | Information & communication | 2002 |
| Roberts Consultancy Ltd | Real estate | 2016 |
| Rockpoint Fire and Security Limited | Construction | 2024 |
| Roofcare (UK) Ltd | Construction | 2025 |
| Roo’S by Reagan, Less IS More. Ltd | Wholesale & retail | 2025 |
| Royle Minerals Ltd | Wholesale & retail | 2020 |
| RT Accounting Ltd | Professional & scientific | 2023 |
| Rtvn Limited | Health & social care | 2013 |
| Ruben Trochez Gynaecology Limited | Health & social care | 2020 |
| Rubix Entertainment Ltd | Arts & recreation | 2024 |
| Ruby Salmon Photography Ltd | Professional & scientific | 2023 |
| Ruibin WU Ltd | Wholesale & retail | 2023 |
| RW Integrated Solutions Limited | Professional & scientific | 2020 |
| S L Oxton Ltd | Hospitality | 2018 |
| S&S Properties North West Ltd | Real estate | 2020 |
| Sabre Business Solutions Ltd | Professional & scientific | 2016 |
| Safe Security (NW) Ltd | Administrative & support | 2011 |
| Safeboxsolutions Ltd | Wholesale & retail | 2025 |
| Salon Supplies 365 Limited | Wholesale & retail | 2015 |
| Salop Service Company Limited | Real estate | 2012 |
| Salopia Catholic Schools Trust | Education | 2015 |
| Sanastasia Limited | Transport & logistics | 2024 |
| Sander Marine Services Limited | Information & communication | 2012 |
| Sara Dental Services Limited | Health & social care | 2020 |
| Satsuma Holdings Ltd | Financial services | 2024 |
| Scitech Innovation Limited | Information & communication | 2017 |
| Scitrox Limited | Professional & scientific | 2022 |
| SDA Architecture Limited | Professional & scientific | 2015 |
| SEASAFE51 Ltd | Construction | 2023 |
| Seize the Clay Pottery Ltd | Education | 2025 |
| Senior Care Services Limited | Health & social care | 2000 |
| Sentiments in Silk Ltd | Wholesale & retail | 2019 |
| Sephton Motors Limited | Wholesale & retail | 2021 |
| Shadow Dance Academy Limited | Education | 2019 |
| Share-A-Pa Limited | Extraterritorial | 2005 |
| Shrewsbury Road Oxton Management Company Limited | Administrative & support | 1987 |
| Shrewsbury Roman Catholic Diocesan Trust | Other services | 2017 |
| Shrewsbury Roman Catholic Diocesan Trustee Limited | Other services | 2022 |
| Shukla Pathology Ltd | Health & social care | 2021 |
| Simpson Direct Limited | Professional & scientific | 1996 |
| Sino Collective Ltd | Real estate | 2020 |
| Skarr Limited | Wholesale & retail | 2012 |
| Skin Breathe Ltd | Wholesale & retail | 2024 |
| SL Mortgage Funding NO 1 Limited | Financial services | 2004 |
| SLE Property Services Ltd | Construction | 2026 |
| Sleep Doctor Limited | Health & social care | 2017 |
| Sleeping Beauties Aesthetics Ltd | Other services | 2022 |
| Sligo Pictures Ltd | Information & communication | 2017 |
| Slings & Support Wirral CIC | Health & social care | 2023 |
| Slnmb Limited | Financial services | 2004 |
| SMI Consulting Ltd | Professional & scientific | 2025 |
| Smith and Snowden Ltd | Wholesale & retail | 2024 |
| Smithmatthias Ltd | Arts & recreation | 2014 |
| Smoketec Limited | Professional & scientific | 2020 |
| Smurf Care Ltd | Health & social care | 2025 |
| Sneaky Mcsneakface Ltd | Wholesale & retail | 2022 |
| Sneakysneaks Ltd | Wholesale & retail | 2021 |
| Solo Security Ltd | Administrative & support | 2026 |
| Solvexuk Ltd | Information & communication | 2025 |