| LEO Lettings Limited | Real estate | 2010 |
| Leon's Kitchen & Grill Ltd | Hospitality | 2024 |
| Leonie Rowe Holdings Limited | Financial services | 2026 |
| Leopold Catering Ltd | Hospitality | 2016 |
| Lesbian Voices of Plymouth C.I.C. | Arts & recreation | 2026 |
| Lescorp Ltd | Information & communication | 2022 |
| LET Recruitment Limited | Administrative & support | 2024 |
| Lettercallow Ltd | Construction | 2009 |
| Level UP Management Limited | Professional & scientific | 2022 |
| Lewin Assistance Services Limited | Professional & scientific | 2024 |
| Lewin Plymouth Limited | Administrative & support | 2026 |
| Lewin South West Limited | Administrative & support | 2023 |
| Lewinnick Cove House Management Limited | Real estate | 2000 |
| Lewis Aviation Solutions Ltd | Manufacturing | 2017 |
| Lewis Distribution Limited | Transport & logistics | 2012 |
| Lewis Hill Lets Ltd | Real estate | 2024 |
| Lewis Marine Limited | Manufacturing | 2013 |
| Lewis Scaffolding Services Limited | Construction | 2023 |
| Lexakel Ltd | Health & social care | 2012 |
| Lexus Crown Rentals Ltd | Administrative & support | 2026 |
| LF Online Training Ltd | Wholesale & retail | 2022 |
| LFP Limited | Financial services | 2003 |
| LFR Autos Ltd | Professional & scientific | 2025 |
| LG - Nails & Beauty Limited | Other services | 2018 |
| LGD Lettings Ltd | Real estate | 2025 |
| Lgio Ltd | Professional & scientific | 2024 |
| Lharrison Autos Ltd | Manufacturing | 2016 |
| LHE Design Ltd | Professional & scientific | 2022 |
| Liam Quick Construction Limited | Construction | 2020 |
| LIB Asset Management Limited | Professional & scientific | 2012 |
| LIB G Limited | Professional & scientific | 2012 |
| LIB H Limited | Professional & scientific | 2012 |
| Liberty Insurance Brokers Ltd | Financial services | 2012 |
| Liberty Pearl Photo & Film Collective Limited | Professional & scientific | 2018 |
| Liberty Yachts Ltd. | Other services | 1986 |
| Libra Cleaning Services Ltd | Administrative & support | 2020 |
| Libra Lepus Limited | Hospitality | 2023 |
| Licensed 2 Train Limited | Administrative & support | 2011 |
| Lidstone (Holdings) Limited | Professional & scientific | 2012 |
| Life Apps LAB Ltd | Information & communication | 2013 |
| Life Balance Therapy CIC | Health & social care | 2024 |
| Life Haven Limited | Health & social care | 2021 |
| Life in Motion Coaching Ltd | Other services | 2023 |
| Life Space Cabins Ltd | Construction | 2016 |
| Life With Tech Ltd | Professional & scientific | 2024 |
| Lifedramar Limited | Wholesale & retail | 2026 |
| Lifestyle Genomics Research Centre Limited | Professional & scientific | 2017 |
| Lifestyle Legacy Ltd | Administrative & support | 2018 |
| Lifestyles (South West) Limited | Construction | 2020 |
| Lift and Land Solutions Limited | Professional & scientific | 2024 |
| Lift Run Events Ltd | Arts & recreation | 2024 |
| Light House Barbers Ltd | Other services | 2023 |
| Lightfold Aerospace Limited | Transport & logistics | 2024 |
| Lighthouse Commercial Cleaning Services Ltd | Administrative & support | 2023 |
| Lighthouse Electrical Solutions Ltd | Construction | 2019 |
| Lighthouse Pools Limited | Wholesale & retail | 2015 |
| Lighthouse Properties Plymouth Ltd | Real estate | 2021 |
| Lighthouse Software Development Limited | Information & communication | 2010 |
| Lighting Imports Limited | Wholesale & retail | 2005 |
| Lightwear Limited | Manufacturing | 1988 |
| Lignum Designs Limited | Professional & scientific | 2017 |
| Lijah Globals Limited | Information & communication | 2026 |
| Likib Limited | Health & social care | 2021 |
| Lilac House Professional Social Work Services Ltd | Health & social care | 2022 |
| Lilian Owen Ltd | Real estate | 2009 |
| Lily Developments (Bristol) Limited | Construction | 2011 |
| Limbs for Life CIC | Manufacturing | 2024 |
| Limbtec Limited | Information & communication | 2002 |
| Limesnapper Limited | Real estate | 2005 |
| Limitless Coach Consulting Ltd | Information & communication | 2021 |
| Lindsay Bradshaw Limited | Health & social care | 2015 |
| Lingerie by Victoria Ltd | Wholesale & retail | 2006 |
| Linked Connections Limited | Households | 2022 |
| Links (SW) Ltd | Health & social care | 2023 |
| Links SW Care Ltd | Health & social care | 2026 |
| Lion House (Plymouth) Limited | Households | 2024 |
| Lipson Family Ltd | Hospitality | 2023 |
| Lipson Properties (Plymouth) Limited | Households | 1984 |
| Liquid Caffeine (UK) Ltd | Wholesale & retail | 2024 |
| Liral-Agridev | | 1995 |
| Liskeard Valeting (SW) Ltd | Administrative & support | 2019 |
| Lisson Grove Commercial Ltd | Other services | 2002 |
| Lists and Data Sources Limited | Information & communication | 2012 |
| Little Brown Dog Limited | Real estate | 2017 |
| Little Calicut Limited | Hospitality | 2025 |
| Little Camden Market Limited | Wholesale & retail | 2013 |
| Little Cowper Trading Ltd | Wholesale & retail | 2026 |
| Little Deers Pre-School Community Interest Company | Education | 2016 |
| Little Eaves (Holbeton) Management Company Limited | Households | 2010 |
| Little Efford House Flat Management Limited | Households | 2005 |
| Little Hemp Shop Limited | Manufacturing | 2018 |
| Little Nippers Childcare Limited | Education | 2012 |
| Little Orchard Montessori (Holdings) Limited | Financial services | 2019 |
| Little Orchard Montessori Nurseries Limited | Education | 2013 |
| Little Pet Supplies Ltd | Wholesale & retail | 2010 |
| Little Rays of Sunshine Childminding Ltd | Health & social care | 2025 |
| Little Stars Holiday Clubs Ltd | Health & social care | 2023 |
| Little Stoke Limited | Hospitality | 2026 |
| Little Voice Big Business Ltd | Administrative & support | 2016 |
| Little Woodford Barns Management Company Limited | Extraterritorial | 2008 |