| Feldman Surgical Services Limited | Health & social care | 2016 |
| Feliciana EFL Limited | Financial services | 2019 |
| Felicity Haythorn Limited | Information & communication | 2022 |
| Felix Engineering Limited | Extraterritorial | 1986 |
| Fenceitsw Ltd | Wholesale & retail | 2018 |
| Fencing Southwest Ltd | Administrative & support | 2023 |
| Fera Tattoo Company Ltd | Arts & recreation | 2025 |
| Ferati Limited | Construction | 2010 |
| Fermor Moss Ltd | Real estate | 2018 |
| Fern OWL Limited | Professional & scientific | 2025 |
| Ferndale Community Tenants Group CIC | Information & communication | 2023 |
| Ferndale New Homes Ltd | Construction | 1997 |
| Fernihough HAY LLP | | 2020 |
| Ferret Trading Ltd | Real estate | 2016 |
| Fertility Southwest Ltd | Administrative & support | 2017 |
| Festivology Ltd | Arts & recreation | 2020 |
| Fhcuts Ltd | Other services | 2023 |
| FI Shop Limited | Hospitality | 2008 |
| Fibre and Carbon Limited | Professional & scientific | 2020 |
| Fibreglass Flat Roofing South West Ltd | Construction | 2010 |
| Fibreglass Supplies Ltd | Wholesale & retail | 2017 |
| Fibreglass Supplies Property Ltd | Real estate | 2019 |
| Fifty DC RTM Company Limited | Households | 2011 |
| FIG and Thyme Ltd | Hospitality | 2022 |
| Filham Park Limited | Construction | 2019 |
| Filsan Foods Limited | Manufacturing | 2019 |
| Final Journeys Ltd | Other services | 2025 |
| Find Larry Ltd | Information & communication | 2022 |
| Find Your Groove C.I.C. | Arts & recreation | 2024 |
| Fine Fit Ltd | Manufacturing | 2025 |
| Fine Green Engineering Ltd | Professional & scientific | 2020 |
| Fine Shine Domestic Cleaning LLP | | 2017 |
| Fineline Carpentry and Building Limited | Construction | 2013 |
| Fineline Carpentry Holdings Limited | Financial services | 2016 |
| Fineline Investments Ltd | Real estate | 2019 |
| Fingoti Limited | Manufacturing | 2018 |
| Finishing WP Ltd | Manufacturing | 2024 |
| Finner Sports Limited | Wholesale & retail | 2026 |
| Finsa Supplies Limited | Wholesale & retail | 2018 |
| Fiona Logie Ltd. | Wholesale & retail | 2015 |
| FIQ Management & Marketing Ltd | Professional & scientific | 2025 |
| Fire Doors Rite Solutions Ltd | Professional & scientific | 2022 |
| Fire Prevention Group Ltd | Financial services | 2017 |
| Fire Safety Matters (South West) Limited | Public administration | 2010 |
| Fire TEC Holdings Ltd | Real estate | 2021 |
| Fire TEC Plymouth Ltd | Wholesale & retail | 2009 |
| Fire-Gard Products (UK) Ltd | Manufacturing | 2020 |
| Firedoorapp Ltd | Information & communication | 2026 |
| Firesec Solutions Limited | Administrative & support | 2016 |
| Firestone Bay Ltd | Administrative & support | 2017 |
| Firestone Marketing Ltd | Professional & scientific | 2021 |
| Firnly Ltd | Wholesale & retail | 2023 |
| Firntec Holdings Ltd | Financial services | 2022 |
| Firntec Ltd | Construction | 2021 |
| Firshaw Ltd | Manufacturing | 2019 |
| First 4 Cladding Limited | Other services | 2014 |
| First 4 Floors (Southwest) Ltd | Wholesale & retail | 2024 |
| First 4 Home Improvements Ltd | Construction | 2025 |
| First 4 Property Ltd | Real estate | 2024 |
| First 4 Travel Ltd | Administrative & support | 2024 |
| First 4 Tutors Ltd | Education | 2021 |
| First Approach Paving Limited | Construction | 2017 |
| First Care South West Limited | Administrative & support | 2009 |
| First Choice Metalwork South West Limited | Construction | 2020 |
| First Class Finish (GRP Repairs) Ltd | Manufacturing | 2024 |
| First Class Group Holdings Ltd | Financial services | 2024 |
| First Class Supply Ltd | Administrative & support | 2016 |
| First Class Support International Ltd | Administrative & support | 2016 |
| First Class Support Ltd | Administrative & support | 2015 |
| First Light South West Ltd | Administrative & support | 1997 |
| First Time Cruises Limited | Extraterritorial | 2024 |
| First Time Games Ltd | Information & communication | 2023 |
| Firstliot Ltd | Information & communication | 2014 |
| Fish SW Ltd | Hospitality | 2023 |
| Fishbar Express Plymouth Limited | Hospitality | 2025 |
| Fishinx Ltd | Wholesale & retail | 2014 |
| Fitz Spence Limited | Wholesale & retail | 2020 |
| Fitzjohns Avenue Ltd | Construction | 2016 |
| Fitzroy Joinery Management Company Limited | Households | 2002 |
| Five Napier Limited | Real estate | 2015 |
| Five Trefusis Terrace Limited | Hospitality | 2005 |
| Fixus Facilities Ltd | Construction | 2009 |
| Fizanto Ltd | Information & communication | 2025 |
| FJR Holdings Limited | Real estate | 2024 |
| Flamesafe (South West) Limited | Construction | 2014 |
| Flameworks C.I.C. | Arts & recreation | 2000 |
| Flash Subsea Ltd | Professional & scientific | 2015 |
| Flashycat Ltd | Wholesale & retail | 2010 |
| Flavour Vapour Limited | Wholesale & retail | 2012 |
| Flavour Vapour Truro Limited | Administrative & support | 2014 |
| Flax Ltd | Wholesale & retail | 2023 |
| Flax Project C.I.C. | Agriculture & fishing | 2023 |
| Fleet Apartments Management Limited | Households | 2019 |
| Fleet Holdings Limited | Financial services | 2024 |
| Flete Estate Holiday Cottages Limited | Hospitality | 2020 |
| Flete Field LAB CIC | Professional & scientific | 2021 |
| Flewitt Developments Ltd | Real estate | 2023 |
| Flex Fitness Plymouth Ltd | Arts & recreation | 2022 |
| Flexible Healthcare Agency Ltd | Health & social care | 2025 |
| Flexible Law Limited | Administrative & support | 2017 |