| Flexihose (Plymouth) Ltd | Manufacturing | 2004 |
| Flexihose Ltd | Manufacturing | 2012 |
| Flexis Investments Ltd | Financial services | 2026 |
| Flint Engineering Solutions Limited | Professional & scientific | 2016 |
| Flintkey Property Management Limited | Real estate | 1984 |
| FLO Martial Arts Limited | Arts & recreation | 2016 |
| Floating Point Solutions LLP | | 2014 |
| Flock South West CIC | Education | 2019 |
| Florenza Global Limited | Professional & scientific | 2016 |
| Florin Iurian Ltd | Other services | 2016 |
| Flourish Homecare Limited | Health & social care | 2011 |
| Flourish Psychology Ltd | Health & social care | 2015 |
| Flow Massage WAX Ltd | Wholesale & retail | 2018 |
| Flow Pools Ltd | Professional & scientific | 2024 |
| Flow Therapies Ltd | Arts & recreation | 2018 |
| Flower Fayre (Plymouth) Limited | Wholesale & retail | 2014 |
| Flowers Mcewan Limited | Financial services | 2001 |
| Fludes Welding and Fabrication Southwest Ltd | Manufacturing | 2025 |
| Fluid Earth Systems Limited | Professional & scientific | 2013 |
| Flux Metal Limited | Professional & scientific | 2006 |
| Flux Sewer Ltd | Construction | 2024 |
| FLY Abroad Consult Ltd | Administrative & support | 2026 |
| FLY Plymouth Limited | Transport & logistics | 2011 |
| Flybay Limited | Wholesale & retail | 2025 |
| Flying Bird 2020 Limited | Hospitality | 2020 |
| Flyview Multi-Services Company Limited | Transport & logistics | 2025 |
| Fm-Class Services Limited | Health & social care | 2020 |
| Focused Memory Productions Limited | Information & communication | 2013 |
| Folcom Limited | Construction | 2005 |
| Folcom One Limited | Real estate | 2026 |
| Foliot Management Ltd | Households | 1991 |
| Fone World Tech Ltd | Wholesale & retail | 2022 |
| Food & More (SW) Ltd | Wholesale & retail | 2024 |
| Food Global Limited | Hospitality | 2019 |
| Food Imperial Limited | Wholesale & retail | 2011 |
| Food IS FUN SW CIC | Education | 2024 |
| Food Plymouth CIC | Health & social care | 2014 |
| FOOD4U Plymouth Ltd | Hospitality | 2019 |
| Foodie PL Ltd | Hospitality | 2014 |
| Foodinvention Ltd | Other services | 2021 |
| Foods 4 U Devon Ltd | Hospitality | 2025 |
| Foodsavers Afromart Ltd | Wholesale & retail | 2024 |
| Foot Anstey Group Limited | Professional & scientific | 1991 |
| Foot Anstey LLP | | 2010 |
| Foot Anstey Secretarial Limited | Professional & scientific | 1997 |
| Foot Anstey Trust Corporation Limited | Professional & scientific | 2014 |
| Foot Forward Podiatry Limited | Health & social care | 2021 |
| Football & Racing Products Ltd | Information & communication | 2024 |
| Football W Borders Ltd | Arts & recreation | 2025 |
| FOR Schools Direct Limited | Education | 2012 |
| Forcer IT Consultancy Services Ltd. | Information & communication | 2013 |
| Ford Park Cemetery Trust | Other services | 1999 |
| Ford Pets Limited | Wholesale & retail | 2016 |
| Foreshore Holdings ( Hessenford ) Limited | Construction | 2023 |
| Foresite Consultants Limited | Professional & scientific | 1995 |
| Forest Vale Management (NO.1) Limited | Households | 1993 |
| Forever Young South West Limited | Health & social care | 2014 |
| Forget ME NOT SW Limited | Health & social care | 2025 |
| Forgiving Plants and Giftware LP | | 2015 |
| Formedia Marketing Limited | Professional & scientific | 2010 |
| Formell Limited | Information & communication | 2013 |
| Formflex Ltd | Construction | 2024 |
| Formula WIN Ltd | Professional & scientific | 2022 |
| Forresters Management Company Limited | Real estate | 2005 |
| Fort Stamford Health and Fitness Limited | Arts & recreation | 2006 |
| Fortis Business Consultancy Ltd | Professional & scientific | 2021 |
| Fortitude Inns Ltd | Hospitality | 2025 |
| Fortitude Innsuk Ltd | Hospitality | 2025 |
| Fortix Engineering Ltd | Information & communication | 2025 |
| Fortuna Plymouth Limited | Administrative & support | 2025 |
| Forward View Financial Ltd | Financial services | 2026 |
| Forza Carpentry & Installations Ltd | Construction | 2023 |
| Fosfeen Ltd | Manufacturing | 2024 |
| Foss Services (UK) Limited | Wholesale & retail | 2013 |
| Foster Building & Developments Ltd | Construction | 2023 |
| Foster Seechurn Morgan LLP | | 2024 |
| Fotonow SW Community Interest Company | Arts & recreation | 2009 |
| Foundry Mews (Tavistock) Management NO.1 Company Limited | Households | 2009 |
| Foundry Parc Management Company Limited | Households | 2007 |
| Fountain Court Management (Teignmouth) Ltd | Households | 2023 |
| Four Elements Catering Ltd | Hospitality | 2018 |
| Four Greens Community Trust CIC | Administrative & support | 2014 |
| Four Rivers Investments Limited | Real estate | 2020 |
| Four Seasons Landscapes (South West) Limited | Administrative & support | 2007 |
| Four Winds Landscaping (Taunton) Limited | Administrative & support | 1989 |
| FOUR26 Ltd | Information & communication | 2015 |
| Fourlines Design Studio Ltd | Professional & scientific | 2021 |
| Foursaturn Films Ltd | Arts & recreation | 2024 |
| Fourwho Ltd | Information & communication | 2017 |
| Fowey Surveyors Ltd | Professional & scientific | 2019 |
| Fowler Radford Ltd | Real estate | 2019 |
| FOX Estates Limited | Real estate | 2025 |
| FOX Hotels Group Limited | Hospitality | 2021 |
| FOX Studios Limited | Extraterritorial | 2014 |
| Foxcroft (Bradley Stoke) Management Company Limited | Households | 1991 |
| Foxglove & Foil Cards Ltd | Wholesale & retail | 2025 |
| Foxy Industries Ltd | Arts & recreation | 2022 |
| Foxygen Ltd | Wholesale & retail | 2025 |
| Foye Properties Ltd | Real estate | 2025 |
| FP Airports Limited | Financial services | 2022 |