| Exclusively Exmoor Limited | Wholesale & retail | 2023 |
| Executive Assessment and Development Services Ltd | Professional & scientific | 2009 |
| Executive Cleaning Services (South West) Limited | Other services | 2000 |
| Executive Hire South West Limited | Extraterritorial | 2017 |
| Executive Hire SW Limited | Transport & logistics | 2001 |
| Executive Lets South West Ltd | Real estate | 2011 |
| Exemplar Life Limited | Professional & scientific | 2020 |
| Exemplar Living Investments Ltd | Real estate | 2021 |
| Exemplar Living Ltd | Construction | 2019 |
| Exeter Fasteners Ltd | Wholesale & retail | 2024 |
| Exeter Heart Holdings Limited | Financial services | 2016 |
| Exeter Heart Limited | Health & social care | 2015 |
| Exeter Vehicle Repairs Ltd | Wholesale & retail | 2020 |
| Exmouth Smoke and Vape Ltd | Wholesale & retail | 2019 |
| Exodex UK Ltd | Information & communication | 2022 |
| Experience-Ledhr Ltd | Administrative & support | 2026 |
| Explorer Court Management Company Limited | Households | 2004 |
| Expo Display Stands Ltd | Administrative & support | 2025 |
| Exportsavvy Limited | Administrative & support | 1994 |
| Express 96 Limited | Hospitality | 2020 |
| Express Diagnostics Limited | Health & social care | 1994 |
| Express Halal Shawarma Ltd | Hospitality | 2024 |
| Expressions by NIX Ltd | Manufacturing | 2024 |
| Exquisite Refreshments Limited | Wholesale & retail | 2024 |
| Exspresso Ltd | Extraterritorial | 2010 |
| Extrasign Limited | Financial services | 2006 |
| Extreme Groundwork’S SW Ltd | Construction | 2026 |
| EYE for Improvement Ltd | Administrative & support | 2016 |
| Eyelash Queen Academy Ltd | Education | 2019 |
| Eyelash Queen Ltd | Other services | 2021 |
| Eyes UP Training Limited | Administrative & support | 2019 |
| EZY Tiles Ltd | Construction | 2023 |
| F & C Plymouth & Salcombe Limited | Real estate | 2025 |
| F . Calladine Optometry Ltd | Health & social care | 2023 |
| F J White (Developments) Ltd | Professional & scientific | 2004 |
| F S Plymouth Ltd | Wholesale & retail | 2008 |
| F&J Vehicle Diagnostics Limited | Wholesale & retail | 2024 |
| F.R. Cross & Sons Limited | Construction | 1976 |
| F.T.B.Lawson Limited | Wholesale & retail | 1919 |
| F1 Hybrid Ltd | Administrative & support | 2011 |
| F3 Design Limited | Professional & scientific | 2017 |
| F34 Design Limited | Professional & scientific | 2025 |
| Faaantasticivils Ltd | Construction | 2019 |
| FAB City Plymouth CIC | Other services | 2022 |
| FAB Ice Ltd | Hospitality | 2019 |
| Fable & Fawn Ltd | Wholesale & retail | 2025 |
| Faby Faby Limited | Hospitality | 2018 |
| Facility Partners Ltd | Administrative & support | 2023 |
| Factory Direct U.P.V.C. Windows Limited | | 1985 |
| Fade & Shave Ltd | Other services | 2025 |
| Fado Limited | Construction | 2009 |
| Fafa DRY Cleaning Ltd | Other services | 2025 |
| Fairchange Limited | Households | 1999 |
| Fairlea House Developments Limited | Real estate | 2019 |
| Fairy Dust Cleaners and Co Ltd | Administrative & support | 2021 |
| Faithful Company Ltd | Transport & logistics | 2025 |
| Falcaty Limited | Real estate | 2020 |
| Falcon Development and Renovation Limited | Real estate | 2024 |
| Falcon Fire and Security Solutions Ltd | Professional & scientific | 2022 |
| Fallon Enterprises Ltd | Real estate | 2017 |
| Falnet Ltd | Information & communication | 2026 |
| Family Haven Care Ltd | Health & social care | 2026 |
| Family Matters of Plymouth | Health & social care | 2005 |
| Fancy Pants Cakes Limited | Manufacturing | 2026 |
| Fancy Stuff Holdings Limited | Financial services | 2025 |
| Fancy Stuff Limited | Financial services | 2016 |
| Fanfluence Ltd | Professional & scientific | 2025 |
| Fanparks Limited | Administrative & support | 2024 |
| Fantastic Footwear Ltd | Wholesale & retail | 2026 |
| Fapril Investments Limited | Real estate | 2023 |
| FAR East Kitchen (UK) Ltd | Other services | 2014 |
| FAR Flung Dance Theatre C.I.C. | Arts & recreation | 2015 |
| FAR Horizons Residents Limited | Households | 2005 |
| Faraday Mill Accident Repairs Limited | Wholesale & retail | 2022 |
| Faraj Consulting Limited | Professional & scientific | 1998 |
| Farm Logic Naturals Limited | Wholesale & retail | 2026 |
| Farmer and Co Limited | Manufacturing | 2011 |
| Farrell TEC Ltd | Administrative & support | 2024 |
| Farriers Cottages Management Company Limited | Households | 2002 |
| Fast & Foremost Consultants Ltd | Professional & scientific | 2023 |
| Fast Futures and Systems Thinking Ltd | Professional & scientific | 2024 |
| Fast Tradesman Interiors Ltd | Construction | 2018 |
| Fatibobo Mini Films Ltd | Information & communication | 2026 |
| Faulkner’S Finishing Ltd | Manufacturing | 2022 |
| Favel Facilitated Ltd | Information & communication | 2018 |
| Favorite Global Services Limited | Administrative & support | 2026 |
| Favourite Food (SW) Ltd | Hospitality | 2025 |
| Favourite Pizza Plymouth Ltd | Hospitality | 2025 |
| Fayoumi Construction Ltd | Construction | 2023 |
| FBF Foods Ltd | Hospitality | 2025 |
| FBY Catering Ltd | Hospitality | 2024 |
| FC Developments SW Limited | Construction | 2019 |
| FCP 500 Ltd | Real estate | 2026 |
| FD South West Limited | Professional & scientific | 2004 |
| FD30-MAINTENANCE Ltd | Construction | 2025 |
| Fearn’S MOT and Autocare Ltd | Wholesale & retail | 2025 |
| FEC Associates Limited | Health & social care | 2025 |
| Federweb Ltd | Wholesale & retail | 2023 |
| FEF Property (NO.2) Limited | Construction | 2018 |
| FEF Property Limited | Real estate | 2018 |