| Equitas Financial Limited | Financial services | 2007 |
| Equitraders Limited | Agriculture & fishing | 2008 |
| Equity Financial Planning Services Ltd | Professional & scientific | 2025 |
| Eraglow Building Limited | Real estate | 1977 |
| Erciyes Kayseri Limited | Hospitality | 2025 |
| Ercle Designs Limited | Professional & scientific | 2009 |
| Erisjo Global Limited | Wholesale & retail | 2025 |
| Ermach Ltd. | Health & social care | 2016 |
| Erme Court (Ivybridge) Management Company Limited | Real estate | 2006 |
| Erme Valley Autos Ltd | Wholesale & retail | 2012 |
| Ermington Terrace RTM Company Limited | Real estate | 2014 |
| Ernesettle Community Solar Limited | Energy | 2015 |
| Esae Limited | Professional & scientific | 2025 |
| Escape Plymouth Ltd | Arts & recreation | 2020 |
| Escapism Plymouth Ltd | Arts & recreation | 2021 |
| Escapology Home Ltd | Wholesale & retail | 2005 |
| ESD Goods Limited | Wholesale & retail | 2025 |
| Eskis Limited | Administrative & support | 2004 |
| ESL Language Services Ltd | Education | 2025 |
| Espar Ltd | Manufacturing | 2011 |
| Esperanto Business Solutions Ltd | Professional & scientific | 2022 |
| Espier Holdings Ltd | Financial services | 2015 |
| Espier Ltd | Manufacturing | 2004 |
| ESQ Grooming Ltd | Other services | 2020 |
| ESS Project Solutions Ltd | Professional & scientific | 2026 |
| Established by HER Ltd | Professional & scientific | 2021 |
| Estate Management 54 Limited | Households | 1998 |
| Esther Omoye Ltd | Health & social care | 2025 |
| Esthwaite Lane (Management) Limited | Households | 2017 |
| Estover MOT Centre Ltd | Wholesale & retail | 2026 |
| Estuary Point (Block 1) Management Company Limited | Households | 1997 |
| Estuary Point Management Company Limited | Households | 1997 |
| Eternity 8 Ltd | Wholesale & retail | 2021 |
| Eternity Pointer Limited | Wholesale & retail | 2025 |
| Ethereal Massage Limited | Other services | 2025 |
| Ethical Activities CIC | Professional & scientific | 2022 |
| Ethos Holdings SW Ltd | Financial services | 2023 |
| Ethos Management Ltd | Professional & scientific | 2024 |
| Ethy Rock Ltd | Professional & scientific | 2021 |
| Etinosa Osagie Films Ltd | Information & communication | 2026 |
| ETP Consult Ltd | Public administration | 2024 |
| Eucalyptus Property Ltd | Hospitality | 2018 |
| Euro Lifts Limited | Construction | 1989 |
| Eurobatt Ltd | Extraterritorial | 2013 |
| Eurocases Plymouth Limited | Manufacturing | 2009 |
| Euroimage International Limited | | 1988 |
| Europa Urology Ltd | Health & social care | 2019 |
| European Elasmobranch Association Limited | Professional & scientific | 1996 |
| Eurospars Limited | Manufacturing | 1986 |
| Eurotech House (Plymouth) Limited | Real estate | 2023 |
| Eurotech Park Management Company Limited | Households | 2022 |
| Eutopia Properties Limited | Real estate | 2025 |
| EV Consultancy Limited | Professional & scientific | 2021 |
| Evalesco Consulting Limited | Professional & scientific | 2015 |
| Evans Accountants SW Ltd | Professional & scientific | 2019 |
| Evans Court Amenity Limited | Real estate | 2003 |
| Evans Estates (Torquay) Limited | Real estate | 1948 |
| Evans Harvey Limited | Professional & scientific | 2003 |
| Evans Living Limited | Real estate | 2026 |
| Evans Transport Consultancy Ltd | Transport & logistics | 2023 |
| Evely Electrical Ltd | Construction | 2006 |
| Even Keel Customs Ltd | Manufacturing | 2024 |
| Event Image Limited | Arts & recreation | 2005 |
| Event Spinners Limited | Arts & recreation | 2025 |
| Event Tech SW Ltd | Administrative & support | 2017 |
| Everboost Ltd | Professional & scientific | 2023 |
| Everest Commerce Limited | Wholesale & retail | 2024 |
| Everest Gurkha Limited | Hospitality | 2018 |
| Everest Ranges Limited | Arts & recreation | 2026 |
| Everett Sales & Marketing Ltd | Administrative & support | 2022 |
| Evergreen Investment Group Limited | Hospitality | 2022 |
| Evermoore Carpentry Limited | Manufacturing | 2023 |
| Everseed Ltd | Administrative & support | 2019 |
| Evershine WCS Ltd | Administrative & support | 2015 |
| Every Corner Distribution Ltd | Transport & logistics | 2017 |
| Everydaystays Ltd | Hospitality | 2023 |
| Everyone Plays CIC | Education | 2026 |
| Everything BUT Theatre Ltd | Arts & recreation | 2024 |
| Everything Cookie Limited | Manufacturing | 2023 |
| EVG Landscapes (SW) Limited | Administrative & support | 2020 |
| Evidall Ltd | Information & communication | 2022 |
| Evident Research Consultancy Ltd | Other services | 2024 |
| EVO Distribution Limited | Wholesale & retail | 2001 |
| EVO Films Ltd | Information & communication | 2005 |
| Evolution IS Limited | Administrative & support | 2003 |
| Evolution Marine Services Ltd | Manufacturing | 2020 |
| Evolution Southwest Ltd | Professional & scientific | 2019 |
| Evolve SW Ltd | Transport & logistics | 2010 |
| Evron Property & Consulting Ltd | Real estate | 2019 |
| Ewaldine Care Group Limited | Health & social care | 2024 |
| Ewawumi Bridal & Beauty Ltd | Other services | 2025 |
| EWG Utilities & Civils Ltd | Construction | 2023 |
| EWI Health Check UK Ltd | Construction | 2023 |
| Ewing Health Ltd | Health & social care | 2022 |
| EWS Holdco Limited | Professional & scientific | 2022 |
| Excaliber Associates Limited | Financial services | 2007 |
| Excel and Inspire Inc Ltd | Administrative & support | 2024 |
| Excel BTL Ltd | Real estate | 2022 |
| Excel Workwear Limited | Wholesale & retail | 2006 |
| Excel Yourself Limited | Extraterritorial | 2005 |