| Elliott Homes SW Ltd | Real estate | 2021 |
| Elliott Jarvis Cars Ltd | Wholesale & retail | 2020 |
| Elliott’S Car Body Repairs Ltd | Wholesale & retail | 2022 |
| Ellipsis Consulting Engineers Ltd | Construction | 2026 |
| Ellis Development Services Limited | Construction | 2025 |
| Ellis John Construction Ltd | Construction | 2017 |
| Elloway Ltd | Construction | 2013 |
| ELM Building Services Ltd | Construction | 2022 |
| ELM Care Management Limited | Health & social care | 2023 |
| ELM Case Management Limited | Health & social care | 2022 |
| ELM Court Management (Plymouth) Limited | Households | 1994 |
| ELM Motor Company Ltd | Wholesale & retail | 2019 |
| ELM Road Management Company Limited | Households | 2004 |
| ELM Therapy Services Ltd | Health & social care | 2010 |
| Elma DR Ltd | Other services | 2025 |
| Elmes Carpentry & Construction Ltd | Construction | 2020 |
| Elms Assist Limited | Extraterritorial | 2014 |
| Elms Aviation Limited | Information & communication | 2015 |
| Elms Global Solutions Limited | Extraterritorial | 2015 |
| Elms Property Group Ltd | Real estate | 2025 |
| Elog Business Advisory Limited | Professional & scientific | 2025 |
| Else Minerals Limited | Mining & quarrying | 2012 |
| Elsie Leigh Fishing Limited | Agriculture & fishing | 2026 |
| Eltigani Limited | Real estate | 2020 |
| Elwell Rose Property Investments Ltd | Real estate | 2023 |
| Elysian Living UK Ltd | Real estate | 2018 |
| Elysian Plastering Ltd | Construction | 2025 |
| Embankment Barber Ltd | Other services | 2021 |
| Embankment Kebab & Pizza Plus Ltd | Hospitality | 2016 |
| Embankment Stores (Plymouth) Limited | Wholesale & retail | 2005 |
| Embre Ltd | Construction | 2026 |
| EMD Cardiology Limited | Administrative & support | 2016 |
| EME18 Ltd | Health & social care | 2021 |
| Emerald Group Limited | Administrative & support | 1998 |
| Emerald Wave Properties Ltd | Real estate | 2024 |
| Emerge QA Limited | Professional & scientific | 2023 |
| Emeris Limited | Real estate | 2001 |
| Emery-Roberts | | 2009 |
| EMI Property Maintenance Ltd | Construction | 2025 |
| Emiter Ltd | Wholesale & retail | 2011 |
| Emma Place Developments Ltd | Real estate | 2015 |
| Emma Place Living Limited | Hospitality | 2022 |
| Emmaus Cornwall | Health & social care | 2012 |
| Emnet Community Management Ltd | Information & communication | 2021 |
| EMP Mail Order UK Ltd | Wholesale & retail | 2007 |
| Empire Consulting (SW) Ltd | Professional & scientific | 2025 |
| Empire Cuts (SW) Ltd | Other services | 2020 |
| Empire Properties & Lets Limited | Real estate | 2024 |
| Employee Finder Limited | Administrative & support | 2015 |
| Emporium Anime Ltd | Other services | 2024 |
| Empower Core Programs CIC | Administrative & support | 2020 |
| Empower Dance and Fitness Studios Ltd | Arts & recreation | 2012 |
| EMS Bakehouse Limited | Manufacturing | 2021 |
| Emzy Enterprise Ltd | Real estate | 2026 |
| Enable Law Limited | Professional & scientific | 1997 |
| Enabling 4 U LLP | | 2013 |
| Encore NW (Building Services) Limited | Construction | 2009 |
| Encorepreneurs' Club Ltd | Information & communication | 2024 |
| Endeavour Marine Solutions Limited | Manufacturing | 2008 |
| Enduro Ltd | Information & communication | 2020 |
| Energy Brokers Ltd | Wholesale & retail | 2018 |
| Energy Compliance Limited | Professional & scientific | 2006 |
| Energy Savings Solutions Southwest Limited | Wholesale & retail | 2023 |
| Energy Synergy Solutions Limited | Construction | 2015 |
| Enfrighten Ltd | Health & social care | 2025 |
| Engage People Development Limited | Professional & scientific | 2006 |
| Engaged Communities C.I.C. | Other services | 2020 |
| Engineering Sales Consultancy Limited | Information & communication | 2014 |
| Engineering Your Cleans Ltd | Administrative & support | 2024 |
| Enginetuner Automotive Ltd | Wholesale & retail | 2025 |
| Enginetuner Ltd | Wholesale & retail | 2002 |
| Engraver World Ltd | Professional & scientific | 2025 |
| ENI Couriers Ltd | Transport & logistics | 2025 |
| ENI Express Ltd | Transport & logistics | 2025 |
| ENI Freight Ltd | Transport & logistics | 2025 |
| Enigma Plymouth Ltd | Real estate | 2018 |
| ENL Properties Ltd | Real estate | 2019 |
| Enterprise Coaching Ltd | Professional & scientific | 2016 |
| Enterprise Gateway International Ltd | Professional & scientific | 2023 |
| Entry Group UK Ltd | Manufacturing | 2020 |
| Entry Locksmiths Limited | Extraterritorial | 2025 |
| Enviraqua Ltd | Wholesale & retail | 2024 |
| Enviro-Reporter Ltd | Professional & scientific | 2024 |
| Envirobuzz Editorial Ltd | Information & communication | 2012 |
| Envirocan Ltd | Administrative & support | 2021 |
| Envirogas UK Ltd | Construction | 2020 |
| Envirolec (SW) Limited | Construction | 2011 |
| Enviroline Drainage Services Ltd | Administrative & support | 2024 |
| Environmental Drone Services Ltd | Professional & scientific | 2024 |
| Environmental Energy (South West) Limited | Professional & scientific | 2002 |
| Environmental Energy Group Ltd | Professional & scientific | 2016 |
| Environmental Land Management and Education Ltd | Agriculture & fishing | 2025 |
| Envisage Sport Ltd | Manufacturing | 2018 |
| Enzo.A.Z Ltd | Wholesale & retail | 2025 |
| EOC Offshore Services Ltd | Professional & scientific | 2024 |
| EP Waste Management Ltd | Water & waste | 2026 |
| Epideco Ltd | Wholesale & retail | 2019 |
| Eprias Ltd | Information & communication | 2018 |
| Equinox Technical Solutions Limited | Professional & scientific | 2001 |
| Equisonics Ltd. | Manufacturing | 2010 |