| E a Grey Construction and Plant Hire Limited | Construction | 2015 |
| E Electrical Limited | Construction | 2020 |
| E G Hingston & SON Ltd | Extraterritorial | 2018 |
| E Happy & Best Meals Limited | Hospitality | 2016 |
| E J Skinner Solutions Limited | Health & social care | 2024 |
| E S International Holdings Limited | Real estate | 2020 |
| E Service Holdings Limited | Financial services | 2025 |
| E Trading & Investments Ltd | Financial services | 2020 |
| E-Marine Solutions Limited | Professional & scientific | 2020 |
| E.T. Brokers Limited | Administrative & support | 2004 |
| E10LONDON Ltd | Professional & scientific | 2015 |
| EA Biolife Ltd | Health & social care | 2023 |
| EA Hilton Ltd | Other services | 2018 |
| EAA Retail Services Ltd | Wholesale & retail | 2026 |
| Eagle Signs Limited | Manufacturing | 1963 |
| Eagles Connect Fragrances Limited | Wholesale & retail | 2025 |
| Eago Estates Ltd | Real estate | 2023 |
| Eago Perfect Home Solutions Ltd | Wholesale & retail | 2018 |
| EAM Eco Surveys Ltd | Professional & scientific | 2026 |
| Eardale Limited | Professional & scientific | 1996 |
| Earth Electrical Services (SW) Limited | Construction | 2022 |
| Earth Energy Education Limited | Education | 2021 |
| Earth Honouring Limited | Health & social care | 2023 |
| Earthworx Holdings Ltd | Professional & scientific | 2020 |
| Ease Homes SW Ltd | Construction | 2025 |
| Ease Retail Ltd | Construction | 2026 |
| East Cornwall Fasteners Ltd | Wholesale & retail | 2024 |
| East Devon Fasteners Ltd | Wholesale & retail | 2024 |
| East EAT Plymouth Ltd | Hospitality | 2024 |
| East Lancs Corporate Travel Limited | Other services | 2009 |
| East Taphouse Management Company Limited | Real estate | 2004 |
| East West Plymouth Ltd | Hospitality | 2020 |
| Eastbourne Motorcycles Ltd | Manufacturing | 2014 |
| Eastern Sunrise Food Limited | Hospitality | 2020 |
| Eastman Clothing Group Limited | Financial services | 2022 |
| Eastman Leather Clothing Ltd | Manufacturing | 2013 |
| Eastman Plymouth Limited | Hospitality | 2017 |
| Easy Cars Plymouth Ltd | Transport & logistics | 2020 |
| Easy Life Recruitment Limited | Administrative & support | 2025 |
| Easy Street Electric Limited | Other services | 2021 |
| Easystrands Ltd | Wholesale & retail | 2018 |
| EAT Republic Limited | Other services | 2010 |
| Eaton Preparation Centre Limited | Wholesale & retail | 2019 |
| EAU1 (Sutton Harbour) Management Limited | Households | 2004 |
| EAU2 (Shepherds Wharf) Management Company Limited | Households | 2005 |
| Ebbrox Ltd | Agriculture & fishing | 2022 |
| Ebnz Shop Ltd | Wholesale & retail | 2025 |
| Ebrington Nails Plymouth Ltd | Other services | 2026 |
| EC Blade Repair Ltd | Manufacturing | 2026 |
| EC Financial Ltd | Financial services | 2023 |
| Eclassroom Limited | Education | 2019 |
| Eco Air (SW) Ltd | Construction | 2015 |
| Eco Engineers South West Ltd | Construction | 2012 |
| Eco Environmental Bird Control Services Ltd | Extraterritorial | 2024 |
| Eco Environmental Services Limited | Administrative & support | 1998 |
| Eco Group (Holdings) Limited | Administrative & support | 2010 |
| Eco Homes South West LLP | | 2013 |
| Eco South West Limited | Construction | 2024 |
| Eco Space (South West) Limited | Construction | 2007 |
| Eco Wash & WAX (Truro) Limited | Administrative & support | 2016 |
| Eco Wash & WAX Limited | Administrative & support | 2014 |
| Eco-Plug Ltd | Professional & scientific | 2020 |
| Ecobags Ltd | Wholesale & retail | 2004 |
| Ecoblitz Laundry Ltd | Administrative & support | 2018 |
| Ecoelec Southwest Ltd | Construction | 2021 |
| Ecofix Appliance Care Ltd | Professional & scientific | 2023 |
| Econova Cleaning Ltd | Administrative & support | 2025 |
| Ecoplas Windows Ltd | Construction | 2021 |
| Ecosavvy Guide Ltd | Professional & scientific | 2025 |
| Ecoshield SW Ltd | Administrative & support | 2025 |
| Ecosystem Approaches Limited | Professional & scientific | 2019 |
| EDA Barber (SW) Ltd | Other services | 2025 |
| EDA Barber Ltd | Other services | 2026 |
| Edcorp Ltd | Professional & scientific | 2022 |
| Eddystone Apartments Ltd | Hospitality | 2025 |
| Eddystone EEL Limited | Manufacturing | 1999 |
| Eddystone Gameworks Ltd | Information & communication | 2022 |
| Eddystone Ltd | Information & communication | 2022 |
| Eddystone Marine Repairs Limited | | 1986 |
| Eddystone Properties Ltd | Real estate | 2016 |
| Eddystone Real Estate Management Limited | Real estate | 2022 |
| Eddystone Search Ltd | Administrative & support | 2024 |
| Eden Carpentry Ltd. | Construction | 2016 |
| Eden Clinic Group Ltd | Professional & scientific | 2025 |
| Eden Clinical Training Academy Ltd | Education | 2025 |
| Eden Cripps Limited | Hospitality | 2020 |
| Eden Homes (S.W.) Limited | Construction | 2001 |
| Eden Living Group Ltd | Hospitality | 2025 |
| Eden Servis Ltd | Health & social care | 2022 |
| Edenspring Care Limited | Health & social care | 2025 |
| Edge M&E Services Ltd | Construction | 2017 |
| Edge to Edge Carpentry Ltd | Manufacturing | 2023 |
| Edgecombe Holdings Limited | Financial services | 2026 |
| Edgemoor Ltd | Transport & logistics | 2024 |
| Edgesheet Ltd | Information & communication | 2020 |
| Edgy Fish Ltd | Real estate | 2016 |
| EDH MOT & Repair Centre Limited | Wholesale & retail | 2009 |
| EDI Transportation Ltd | Transport & logistics | 2025 |
| Edison & Co Removals Ltd | Transport & logistics | 2025 |
| EDM Catering Limited | Hospitality | 2013 |