| Drake Scaffolding Services Ltd | Construction | 2012 |
| Drakes (Jewellers) Limited | Wholesale & retail | 1950 |
| Drakes DUM Ltd | Hospitality | 2024 |
| Drakes Island Tours and Events Limited | Arts & recreation | 2022 |
| Drakes Meadow Management Ltd | Households | 2012 |
| Draper & Co Limited | Financial services | 2005 |
| Drax Fitness UK Ltd | Wholesale & retail | 2020 |
| Dreadnought Offshore Inspection Services Limited | Professional & scientific | 2012 |
| Dream (South West) Limited | Other services | 2004 |
| Dream Bathing Installations Ltd | Construction | 2007 |
| Dream Bathrooms (SW) Ltd | Construction | 2016 |
| Dream Bathrooms Ltd | Construction | 2007 |
| Dream Kitchens (SW) Ltd | Construction | 2015 |
| Dream Mortgages Ltd | Financial services | 2021 |
| Dream Street Limited | Real estate | 2024 |
| Dreambodyclub Ltd | Information & communication | 2015 |
| Dress Dreamer Ltd | Wholesale & retail | 2021 |
| Drew & Co. (Electrical Contractors) Ltd | Construction | 1999 |
| Drew & Co. Trading Holdings Limited | Construction | 2018 |
| Drew Dyer Carpentry Ltd | Manufacturing | 2024 |
| Drew M Carpentry Ltd | Construction | 2023 |
| Drinkmaster Limited | Wholesale & retail | 2013 |
| Drippeeuk Ltd | Wholesale & retail | 2026 |
| Drive Phase Sports and Fitness Ltd | Arts & recreation | 2012 |
| Drive-App Ltd | Extraterritorial | 2022 |
| Drivers Group Ltd | Transport & logistics | 2024 |
| DRJ Carpentry & Maintenance Ltd | Manufacturing | 2020 |
| Drogon Developments Ltd | Construction | 2019 |
| Dropet Ltd | Wholesale & retail | 2025 |
| Dropkit Products UK Ltd | Wholesale & retail | 2025 |
| DRS Building Services Ltd | Construction | 2010 |
| DRS Perillas Limited | Hospitality | 2025 |
| Drumstyle Properties Limited | Administrative & support | 2009 |
| Drylining Training (SW) Limited | Administrative & support | 2015 |
| DS Brickwork Ltd | Construction | 2013 |
| DS Building Services SW Ltd | Construction | 2024 |
| DS Burton Limited | Hospitality | 2018 |
| DS Green Assessments Ltd | Professional & scientific | 2020 |
| DS Marina Repairs Ltd | Professional & scientific | 2022 |
| DS Property & Developments Ltd | Construction | 2024 |
| DS Property Plymouth Ltd | Real estate | 2017 |
| DSF Communications Limited | Information & communication | 2005 |
| DSH (Southampton) Limited | Real estate | 2024 |
| DSL Marine Ltd | Manufacturing | 2026 |
| DST Interiors Limited | Construction | 2015 |
| DSW Scaffolding Ltd | Construction | 2022 |
| DT Plastics Limited | Construction | 2012 |
| DTD Cleaning Services Limited | Administrative & support | 2025 |
| DTE Electrical Brothers Limited | Construction | 2021 |
| DTL Carpentry Limited | Construction | 2014 |
| DTM Car Sales Plymouth Ltd | Wholesale & retail | 2020 |
| Dual Bar Limited | Hospitality | 2013 |
| Dualmind Ltd. | Professional & scientific | 2017 |
| Duchy Environmental Limited | Professional & scientific | 1996 |
| Duchy Ltd | Construction | 2009 |
| Dudding Court Owners RTM Company Ltd | Real estate | 2023 |
| Dudley Property Inventory Ltd | Real estate | 2025 |
| Duftar Limited | Information & communication | 2016 |
| Duhok (SW) Ltd | Hospitality | 2024 |
| Duignan Holdings Ltd | Financial services | 2025 |
| Dumnonia Property Development (Elmcroft) Limited | Real estate | 2019 |
| Dumnonia Property Development (Seaton) Limited | Real estate | 2018 |
| Dumnonia Property Development Limited | Financial services | 2018 |
| Duncan Lamb Consultants Limited | Other services | 2013 |
| Dunchaul Limited | Transport & logistics | 2006 |
| Duniya Express Ltd | Hospitality | 2026 |
| Dunlewey Limited | Households | 2001 |
| Dunne Right Construction Ltd | Construction | 2020 |
| Dunya Restaurants Ltd | Hospitality | 2019 |
| Duporth Development Community Interest Company | Households | 2010 |
| Dupree Developments Ltd | Professional & scientific | 2026 |
| Duquesa Investments Limited | Professional & scientific | 2025 |
| Durnford Management Company Limited | Households | 2000 |
| Durnford Street Ltd | Administrative & support | 2017 |
| Durum 2 Go Limited | Hospitality | 2023 |
| Duskmoor Property Management Limited | Households | 1983 |
| Dusty Corners Limited | Other services | 2014 |
| DV Invest Ltd | Real estate | 2022 |
| DV Marine Ltd | Professional & scientific | 2017 |
| DV Structural Engineering Ltd | Professional & scientific | 2021 |
| DW Developments (SW) Ltd | Real estate | 2020 |
| DW Drylining Limited | Construction | 2026 |
| DW O'Hare Ltd | Construction | 2016 |
| DW Roofing Contractors Ltd | Construction | 2021 |
| DW7 Consultants Ltd | Professional & scientific | 2019 |
| DWB Consultancy Services Ltd | Information & communication | 2017 |
| Dwg-Fibreflownetworks Ltd | Professional & scientific | 2026 |
| DWU Trading Ltd | Other services | 2025 |
| Dyers Estates Ltd | Real estate | 2025 |
| Dymond Court Management Limited | Households | 2002 |
| Dynamic Edge Marketing and PR Ltd | Professional & scientific | 2025 |
| Dynamic Engineering Services Ltd | Construction | 2016 |
| Dynamic Pressure Wash Services Ltd | Administrative & support | 2026 |
| Dynamic Roots Natural Health Limited | Wholesale & retail | 2022 |
| Dynamx Media Ltd. | Information & communication | 2020 |
| Dynasty Trowels Ltd | Construction | 2025 |
| Dyplens Limited | Manufacturing | 2022 |
| Dyslexia Assistance Ltd | Health & social care | 2022 |
| E & L Rental Properties Limited | Real estate | 2016 |
| E & T Developments Limited | Real estate | 2001 |