| Dentus Ltd | Health & social care | 2014 |
| Deostara Ltd | Education | 2018 |
| Depo Events Group Ltd | Arts & recreation | 2021 |
| Depo Venue Group Limited | Hospitality | 2020 |
| Depø Studio Group Ltd | Information & communication | 2022 |
| Derek Watson Renovations Ltd | Real estate | 2017 |
| Derma Tuff Ltd | Professional & scientific | 2007 |
| Dermatuff International Ltd | Professional & scientific | 2005 |
| Derriford Hospital League of Friends Shop Ltd | Wholesale & retail | 1998 |
| Derwent Plymouth Limited | Construction | 2012 |
| Design Accessories Ltd | Other services | 2024 |
| Design and Invent Ltd | Manufacturing | 2018 |
| Design Build WOW Ltd | Information & communication | 2017 |
| Design Development Ltd | Professional & scientific | 2003 |
| Design Windows Limited | Manufacturing | 1982 |
| Designer Bins Limited | | 1988 |
| Designer Plans Limited | Wholesale & retail | 2007 |
| Designrstudio Limited | Extraterritorial | 2013 |
| Deslandes S Ltd | Construction | 2016 |
| Desoirepropertyco Ltd | Real estate | 2025 |
| Destination CMS Ltd | Professional & scientific | 2013 |
| Destination Innovations Ltd | Administrative & support | 2019 |
| Destination YOU Ltd | Administrative & support | 2019 |
| Detectt Ltd | Professional & scientific | 2019 |
| Detectt Subsea Ltd | Information & communication | 2014 |
| Detour Decorators Ltd | Construction | 2026 |
| Detoxs Consulting Limited | Professional & scientific | 2014 |
| Devcor (Victoria) Limited | Real estate | 2015 |
| Devcor (Whitewater) Limited | Real estate | 2015 |
| Devocean Seafood Limited | Agriculture & fishing | 2019 |
| Devon & Cornwall Computers Limited | Other services | 2018 |
| Devon & Cornwall Damp Solutions Ltd | Construction | 2022 |
| Devon & Cornwall Food Action Ltd | Hospitality | 2010 |
| Devon & Cornwall Hire Limited | Administrative & support | 2008 |
| Devon & Cornwall Motorhome and Caravan Repair Centre Ltd | Wholesale & retail | 2021 |
| Devon & Cornwall Planning Consultants Ltd | Professional & scientific | 2021 |
| Devon & Cornwall Properties Ltd | Real estate | 2021 |
| Devon & Cornwall Property & Facilities Solutions Ltd | Construction | 2019 |
| Devon & Cornwall Solutions Limited | Manufacturing | 2014 |
| Devon & Cornwall Training Providers Network Limited | Education | 2005 |
| Devon Access Taxis Ltd | Transport & logistics | 2025 |
| Devon and Cornwall Affordable Housing Community Interest Company | Households | 2006 |
| Devon and Cornwall Carpentry Ltd | Manufacturing | 2026 |
| Devon and Cornwall Cleaning Ltd | Administrative & support | 2025 |
| Devon and Cornwall Construction Limited | Construction | 2026 |
| Devon and Cornwall Furniture Reuse Project Limited | Wholesale & retail | 2011 |
| Devon and Cornwall Scrap Cars Ltd | Mining & quarrying | 2021 |
| Devon Bumpkin Limited | Information & communication | 2023 |
| Devon Cleaning Services and Property Maintenance Ltd | Administrative & support | 2021 |
| Devon Commercial Painters Ltd | Construction | 2024 |
| Devon County Fasteners Ltd | Wholesale & retail | 2024 |
| Devon County Properties Limited | Real estate | 2002 |
| Devon Disposals Limited | Water & waste | 2025 |
| Devon Domestics Limited | Manufacturing | 2014 |
| Devon Duvets Holdings Ltd | Financial services | 2022 |
| Devon Duvets Limited | Wholesale & retail | 2022 |
| Devon Equine Trailer Hire Ltd | Administrative & support | 2022 |
| Devon Glamping Ltd | Hospitality | 2018 |
| Devon Grease Traps Ltd | Manufacturing | 2024 |
| Devon Heat Project Limited | Construction | 2026 |
| Devon Holiday Lets Ltd | Hospitality | 2020 |
| Devon House Management Limited | Households | 2001 |
| Devon Kebab Pizza Limited | Hospitality | 2024 |
| Devon Lifestyles Limited | Construction | 2002 |
| Devon Luxury Escapes Limited | Hospitality | 2020 |
| Devon Management Services Ltd | Administrative & support | 2018 |
| Devon Mexican Ltd | Hospitality | 2025 |
| Devon Mind | Health & social care | 2016 |
| Devon Oak Interiors Ltd | Construction | 2018 |
| Devon Pasties & Pies Ltd | Manufacturing | 2010 |
| Devon Print Group Ltd | Manufacturing | 2017 |
| Devon Roofing Services Ltd | Construction | 2024 |
| Devon Roots Ltd | Hospitality | 2026 |
| Devon Rugby Referees' Society Ltd | Arts & recreation | 2017 |
| Devon Sailing Experiences Ltd | Administrative & support | 2014 |
| Devon Stainless Limited | Manufacturing | 2016 |
| Devon Star Limited | Hospitality | 2024 |
| Devon Stoves Ltd. | Construction | 2006 |
| Devon Tors Properties Limited | Real estate | 2000 |
| Devon Training Hub Limited | Health & social care | 2017 |
| Devon Trowels Ltd | Construction | 2026 |
| Devon Wick Candle Co. Limited | Wholesale & retail | 2019 |
| Devon&Cornwall Build Group Limited | Construction | 2023 |
| Devon's Finest Hot Chocolate Bombs & Treats Ltd | Hospitality | 2024 |
| Devon, Exeter and Plymouth Chamber of Commerce | Administrative & support | 1958 |
| Devonia Court Limited | Real estate | 2022 |
| Devonport Construction Limited | Construction | 2005 |
| Devonport Curry House Ltd | Hospitality | 2026 |
| Devonport High School for Boys Academy Trust | Education | 2011 |
| Devonport High School for Boys Community Trust CIC | Education | 2019 |
| Devonport High School for Girls | Education | 2011 |
| Devonport Live CIC | Hospitality | 2017 |
| Devonshire House Management Company (Tavistock) Limited | Households | 1995 |
| Devonshire Villas Ltd | Hospitality | 2017 |
| Devran Takeaway Ltd | Hospitality | 2025 |
| Dewerstone Limited | Manufacturing | 2013 |
| DG Developments South West Ltd | Construction | 2025 |
| DG Plumbing & Heating Services Limited | Manufacturing | 2016 |
| DGB Home Surveys Ltd | Professional & scientific | 2022 |
| Dgbqs Ltd | Professional & scientific | 2012 |