| DAW and Sons Building Contractors Limited | Construction | 2026 |
| DAW Training Limited | Education | 2013 |
| Dawbury Limited | Real estate | 2007 |
| Dawe Electrical Services South West Ltd | Construction | 2022 |
| Dawes Lane Management Limited | Households | 2007 |
| Dawn Chafer Limited | Education | 2024 |
| Dawntilduskestates Ltd | Hospitality | 2025 |
| Dawson Southway Limited | Construction | 2015 |
| Dawstep Coffee Limited | Hospitality | 2024 |
| Dawsteps Coffee Ltd | Hospitality | 2026 |
| Dawvid House Maintenance (Plymouth) Limited | Households | 1972 |
| Day and Night Driving School Limited | Health & social care | 2023 |
| Day Welding and Inspection Ltd | Professional & scientific | 2021 |
| Daylite Limited | Real estate | 2022 |
| DB Catering Limited | Hospitality | 2025 |
| DB Creative Development Ltd | Health & social care | 2011 |
| DB Fabs Limited | Manufacturing | 2024 |
| DB Heating Limited | Construction | 2005 |
| DB Property Holdings (South West) Ltd | Real estate | 2025 |
| DBB Business Holdings Limited | Financial services | 2023 |
| DBB Leisure Ltd | Hospitality | 2020 |
| Dbcb Holdings Ltd | Financial services | 2022 |
| DBS (Falmouth) Ltd | Education | 2021 |
| DBS Music UK Holdings Limited | Education | 2018 |
| DBW Solutions Ltd | Construction | 2016 |
| DC Carpentry and Home Improvements Ltd | Construction | 2024 |
| DC City Limited | Hospitality | 2020 |
| DC Energy (SW) Ltd | Construction | 2017 |
| DC Lane Property Services Ltd | Real estate | 2022 |
| DC Lifts Limited | Construction | 2015 |
| DC Projects & Maintenance Ltd | Construction | 2026 |
| DC7 Group Ltd | Professional & scientific | 2018 |
| DCF Industrial Limited | Professional & scientific | 2024 |
| DCL Sameday Ltd | Transport & logistics | 2024 |
| Dclick Solutions Ltd | Administrative & support | 2025 |
| DCO Holdings Ltd | Real estate | 2018 |
| DCP Building Contractors Ltd | Construction | 2006 |
| DCS Roofing and Cladding Ltd | Construction | 2019 |
| DD Interiors (SW) Ltd | Construction | 2025 |
| DD Plymouth Limited | Hospitality | 2024 |
| Ddhg Property Limited | Real estate | 2019 |
| Ddjglobal Ltd | Wholesale & retail | 2019 |
| DDK Autocare Ltd | Wholesale & retail | 2023 |
| Ddrc Healthcare | Health & social care | 1980 |
| Ddrc Medical Services Limited | Health & social care | 2011 |
| Ddrc Professional Services Limited | Professional & scientific | 1994 |
| Ddronemasters & at Services Ltd | Professional & scientific | 2022 |
| DE Van Automotive Limited | Wholesale & retail | 2012 |
| De-Collections Ltd | Wholesale & retail | 2025 |
| Deanne Hancock Property Ltd | Real estate | 2017 |
| Deano's Floor Screeding Limited | Construction | 2017 |
| Deaton Installations Ltd | Construction | 2020 |
| Debbie Dieke Limited | Health & social care | 2025 |
| Deborah Mccann Ltd | Construction | 2011 |
| Decoding the Limelight Ltd | Information & communication | 2024 |
| Decorating Solutions South West Limited | Construction | 2018 |
| Dedeler Limited | Hospitality | 2024 |
| DEE Castle House Ltd | Hospitality | 2019 |
| Deep Sea Systems Limited | Manufacturing | 2014 |
| Deepblue Accountants Ltd | Professional & scientific | 2011 |
| Deepship Engineering Ltd | Professional & scientific | 2018 |
| Deer Park Convenience Stores Limited | Wholesale & retail | 2024 |
| Deer Park Road Trading Limited | Construction | 2017 |
| Deer Park Stores Ltd | Wholesale & retail | 2015 |
| Deerman Consulting Limited | Information & communication | 2023 |
| Define (SW) Ltd | Wholesale & retail | 2015 |
| Defined Beauty Ltd | Other services | 2017 |
| Defnas Homes Ltd | Real estate | 2025 |
| Delamore Arts Ltd | Arts & recreation | 2004 |
| Delex BIZ World Ltd | Wholesale & retail | 2025 |
| Delight Stoke Kebab Pizza Plymouth Ltd | Hospitality | 2024 |
| Delightful Decadence Ltd | Wholesale & retail | 2024 |
| Delilahs at the Postgrad Ltd | Hospitality | 2023 |
| Delivery Partners Limited | Transport & logistics | 2002 |
| Delivery Vision Limited | Wholesale & retail | 2023 |
| Dell'Anno Studio Ltd | Professional & scientific | 2024 |
| Deloraine Residents Management Limited | Households | 1987 |
| Delphic Resource Limited | Administrative & support | 2019 |
| Delt Shared Services Limited | Administrative & support | 2014 |
| Delt Trading Ltd | Administrative & support | 2024 |
| Delta Construction (SW) Ltd | Construction | 2019 |
| Delta Engineering (SW) Ltd | Professional & scientific | 2019 |
| Delta Engineering Plymouth Limited Liability Partnership | | 2003 |
| Delta Nine Eight Ltd | Professional & scientific | 2025 |
| Delta Veterinary Group Ltd | Agriculture & fishing | 2021 |
| Deltha Limited | Professional & scientific | 2013 |
| Delton Properties & Partners Ltd | Real estate | 2025 |
| Deluxe Construction SW Ltd | Construction | 2025 |
| Dema Investments Ltd | Real estate | 2021 |
| Demco Builders Ltd | Construction | 2017 |
| Deme Musker Media Limited | Information & communication | 2025 |
| Demille Consulting Ltd | Professional & scientific | 2012 |
| Dempsey Prosurv Ltd. | Other services | 1987 |
| Denham Productions Limited | Arts & recreation | 1985 |
| Dennison Telecom Services Ltd. | Information & communication | 2015 |
| Dent Support Ltd | Health & social care | 2020 |
| Dental HR Limited | Administrative & support | 2017 |
| Dentist Nearby Ltd | Information & communication | 2025 |
| Dentmaster (SW) Limited | Wholesale & retail | 2008 |
| Dents Events Ltd | Arts & recreation | 2007 |