| Dglets Ltd | Real estate | 2023 |
| DGV Electrical Ltd | Construction | 2026 |
| DH Carpet and Flooring Ltd | Construction | 2017 |
| DH Living Ltd | Real estate | 2025 |
| Dhaka Curry House Ltd | Hospitality | 2025 |
| Dhakal Property Limited | Real estate | 2021 |
| Dhbc Consult Ltd | Construction | 2014 |
| Dhirvi Ltd | Wholesale & retail | 2025 |
| Dhlb Property Ltd | Real estate | 2021 |
| Dhrona Holdings Ltd | Professional & scientific | 2014 |
| DIA Beauty Studio Ltd | Other services | 2019 |
| Diadem Holdings Limited | Health & social care | 2016 |
| Dial a BAG Limited | Administrative & support | 2012 |
| Dial a Shed Limited | Administrative & support | 2012 |
| Diamond Car Valeting Centre Ltd | Administrative & support | 2018 |
| Diamond Double Glazing Plymouth Limited | Manufacturing | 2016 |
| Diamond Drilling Services (SW) Limited | Construction | 2013 |
| Diana Events Ltd | Hospitality | 2023 |
| Diaspora AI Ltd | Information & communication | 2025 |
| Dice and Duel Ltd | Wholesale & retail | 2020 |
| Didbeans Coffee Ltd | Hospitality | 2022 |
| Different View Photography Ltd | Professional & scientific | 2019 |
| DIG & Dredge Ltd | Agriculture & fishing | 2023 |
| Diggit Limited | Construction | 2014 |
| Digi IT Consulting Ltd | Information & communication | 2013 |
| Digital Governance & Transformation Alignment Ltd | Professional & scientific | 2026 |
| Digital Plymouth CIC | Administrative & support | 2017 |
| Digital Retail Ltd | Wholesale & retail | 2021 |
| Digital Safety Records Ltd | Manufacturing | 2026 |
| Digital Solutions Incorporated Ltd | Information & communication | 2011 |
| Digitalclarityservices Ltd | Wholesale & retail | 2026 |
| Digmala Limited | Financial services | 2018 |
| Dikefalos Limited | Health & social care | 2023 |
| Dilisk Ltd | Manufacturing | 2026 |
| Dillybrook Business Services Limited | Real estate | 2023 |
| Dimara Limited | Financial services | 2023 |
| Dimchovski Ltd | Wholesale & retail | 2016 |
| Dimpsy's Diner Ltd | Hospitality | 2023 |
| Dine Central Limited | Hospitality | 2016 |
| Dingle Cleaning Limited | Administrative & support | 2016 |
| Dingle Dollies Cleaning Limited | Administrative & support | 2016 |
| Dingle Property Company Ltd | Real estate | 2013 |
| Dino (SW) Ltd | Hospitality | 2019 |
| Dino Barber Limited | Other services | 2024 |
| Dionisos Ltd | Wholesale & retail | 2023 |
| DIR3CT Group Ltd | Construction | 2025 |
| Direct Access Ltd | Construction | 2021 |
| Direct Consultancy Services Limited | Professional & scientific | 1995 |
| Direct Financial Planning Ltd | Financial services | 2002 |
| Direct Property Services SW Ltd | Construction | 2014 |
| Direct Shot Media Ltd | Information & communication | 2021 |
| Direct Success Ltd | Administrative & support | 2022 |
| Dirt Zero Ltd | Administrative & support | 2025 |
| Dirty Brew Ltd | Hospitality | 2026 |
| Disc Manufacturing Services Ltd | Manufacturing | 2004 |
| Discover Deliver Ltd | Information & communication | 2022 |
| Discover Folley Ltd | Construction | 2006 |
| Discovery Bugs Ltd | Education | 2018 |
| Discovery Divers (Plymouth) Limited | Transport & logistics | 2003 |
| Discovery Martial Arts Academy Ltd | Arts & recreation | 2015 |
| Discovery Property Renovations Ltd | Construction | 2017 |
| Discovery Technologies Ltd | Professional & scientific | 2023 |
| Discovery Wharf (Plymouth) RTM Company Limited | Households | 2010 |
| Disruption Works Ltd | Information & communication | 2017 |
| Distil IT Limited | Professional & scientific | 2015 |
| Distinct Homes South West Ltd | Real estate | 2022 |
| District Healthcare Limited | Health & social care | 2021 |
| Ditto International Ltd | Wholesale & retail | 2017 |
| Diva Nails & Beauty Plymouth Ltd | Other services | 2022 |
| Dive System Services Ltd | Professional & scientific | 2026 |
| Diverse Creative South West Ltd | Professional & scientific | 2023 |
| Diverse Events CIC | Administrative & support | 2019 |
| Diverse Minds Virtual Solutions CIC | Administrative & support | 2025 |
| Diverse Traffic Management Ltd | Transport & logistics | 2026 |
| Diversity Business Incubator CIC | Professional & scientific | 2018 |
| Divine Aesthetics by KA Limited | Other services | 2025 |
| Divine Door & Gate Automation Ltd | Construction | 2026 |
| Divine Grace Solutions Ltd | Health & social care | 2025 |
| DJ Courtney Ltd | Health & social care | 2016 |
| DJ Property Services SW Ltd | Construction | 2026 |
| DJ Property South West Limited | Real estate | 1976 |
| DJ Wilkins Property Limited | Real estate | 2023 |
| DJB Carpentry & Construction SW Ltd | Construction | 2020 |
| Djboxofm Ltd | Professional & scientific | 2025 |
| Djiogo Ltd | Transport & logistics | 2018 |
| DJJ Bricklaying Ltd | Construction | 2026 |
| DJR Infra Services Ltd | Information & communication | 2018 |
| DJR Plant Ltd | Construction | 2023 |
| DJW Marketing Ltd | Professional & scientific | 2025 |
| DK Construction South West Ltd | Construction | 2020 |
| DK Imaging Ltd | Health & social care | 2022 |
| DK Recruitment Services Ltd | Administrative & support | 2024 |
| DKC Engineering Consultants Ltd | Professional & scientific | 2025 |
| DKF Housing Solutions Ltd | Real estate | 2025 |
| DKO Investments Ltd | Construction | 2025 |
| DL Engineering Services Ltd | Professional & scientific | 2018 |
| DL Painting Ltd | Construction | 2023 |
| DL Publishing Limited | Wholesale & retail | 2024 |
| DLS Properties Ltd | Real estate | 2012 |
| DM & LU Ltd | Hospitality | 2015 |