| Salopian Care Limited | Health & social care | 2006 |
| Sanders Brow (Armathwaite) Limited | Construction | 2018 |
| Sandgate Friery Limited | Hospitality | 2013 |
| Sandsfield Way (Carlisle) Limited | Construction | 2022 |
| Sandsfield Way (Carlisle) Management Company Limited | Real estate | 2026 |
| Sawdust 'N' Stitches Limited | Professional & scientific | 2004 |
| Sawyers Global Solutions Limited | Professional & scientific | 2024 |
| Saxon Holdings (North West) Limited | Real estate | 1988 |
| SB - Roth Limited | Real estate | 2006 |
| SBK Business Solutions Ltd | Administrative & support | 2014 |
| Scada Logix Ltd | Professional & scientific | 2012 |
| Scale Degrees Ltd | Information & communication | 2017 |
| Scales Plantation LLP | | 2010 |
| Scarside Farming LLP | | 2025 |
| Scent From Cumbria Ltd | Manufacturing | 2024 |
| Scott Access Limited | Professional & scientific | 2024 |
| Scott Duff & Co Limited | Professional & scientific | 2011 |
| Scott Duff and Co Holdings Ltd | Financial services | 2024 |
| Scottmcinnesart Limited | Arts & recreation | 2014 |
| Sculpt Personal Training Limited | Arts & recreation | 2011 |
| Seager Medical Ltd | Health & social care | 2024 |
| Seagraves and Dixon Limited | Wholesale & retail | 2007 |
| Sealbhanach Limited | Wholesale & retail | 2003 |
| Seas the Life Limited | Administrative & support | 2019 |
| Seavor (South Cumbria) Limited | Professional & scientific | 2011 |
| Seedsense Ltd | Agriculture & fishing | 1997 |
| Select Rural Ltd | Agriculture & fishing | 2024 |
| Selective Solutions Limited | Manufacturing | 2018 |
| Sentreos Ltd | Financial services | 2021 |
| SGE Medical Services Ltd | Health & social care | 2023 |
| Shackleton House Property Management Limited | Real estate | 2011 |
| SHAKESPEARE74 Limited | Professional & scientific | 2026 |
| Shap Village Store Ltd | Wholesale & retail | 2023 |
| Sharkey Communications Limited | Real estate | 2018 |
| Sharp Teleradiology Limited | Health & social care | 2018 |
| Shaun Brown Accountants Ltd | Professional & scientific | 2020 |
| Shaun Marston Building Management Limited | Construction | 2006 |
| Shepherd Groundworks Holdings Limited | Financial services | 2023 |
| Shepherd Utilities Ltd | Construction | 2024 |
| Shepherds Inn Langwathby Limited | Hospitality | 2017 |
| Siddle Retail Limited | Extraterritorial | 2015 |
| Sientries Ltd | Arts & recreation | 2016 |
| Sierra (G.B.) Ltd | Wholesale & retail | 2003 |
| Signal Aspects Limited | Manufacturing | 2007 |
| Signature BNB Management Limited | Hospitality | 2022 |
| Signature Concierge Franchises Limited | Professional & scientific | 2023 |
| Signature Concierge Housekeeping East Lakes Ltd | Administrative & support | 2019 |
| Signature Concierge Housekeeping Ltd | Administrative & support | 2018 |
| Signature Concierge Housekeeping North Lakes Limited | Administrative & support | 2019 |
| Signature Concierge Housekeeping Northumberland Limited | Administrative & support | 2022 |
| Signature Concierge Housekeeping South Lakes Limited | Administrative & support | 2013 |
| Signature Concierge Housekeeping West Lakes Ltd | Administrative & support | 2021 |
| Signature Concierge Housekeeping Yorkshire Dales Limited | Administrative & support | 2022 |
| Signature Concierge Services Ltd | Real estate | 2019 |
| Silver and Green of Lakeland Limited | Wholesale & retail | 2006 |
| Silverband Falconry Limited | Arts & recreation | 2007 |
| Silviculture Academy CIC | Education | 2025 |
| Simba Forestry Limited | Professional & scientific | 2019 |
| Simon Vogt Weddings Limited | Other services | 2023 |
| Simplii LED Lighting Ltd | Manufacturing | 2023 |
| Simpson Bros Ltd | Real estate | 2024 |
| Simpson Site Support Services Limited | Construction | 2026 |
| Simuserv Ltd | Wholesale & retail | 2021 |
| Sitiming Limited | Professional & scientific | 2024 |
| SJ Design Service Ltd | Information & communication | 2013 |
| SJD Couriers Ltd | Transport & logistics | 2024 |
| SJM Construction Ltd | Construction | 2026 |
| SK Environmental Solutions Limited | Professional & scientific | 2011 |
| Skart Construction Limited | Construction | 2011 |
| Skiddaw House Foundation | Other services | 2007 |
| Skidmark Media Ltd | Information & communication | 2021 |
| Skill Shift Training Limited | Education | 2026 |
| Skinny Dog Limited | Information & communication | 1998 |
| Skirsgill Limited | Households | 1981 |
| Skirwith Abbey Limited | Agriculture & fishing | 2012 |
| Skirwith Hall Farms Limited | Agriculture & fishing | 2002 |
| Skog's Logs Limited | Agriculture & fishing | 2009 |
| Skyelda Ltd | Financial services | 2024 |
| Skyla-Iona Ltd | Real estate | 2023 |
| Sl&Wt Ltd | Real estate | 2022 |
| SLT Agricultural Services Ltd | Agriculture & fishing | 2017 |
| SMA Cleaning Systems Ltd. | Manufacturing | 2015 |
| Smallthwaite Farms Limited | Agriculture & fishing | 2006 |
| Smallworld Pre-School & Link Clubs Limited | Education | 2001 |
| Smart Construction (SW) Limited | Construction | 2019 |
| SMI1 Limited | Financial services | 2024 |
| Smile Concepts & Design Limited | Health & social care | 2023 |
| Smith & Co (Holdings) Limited | Financial services | 2017 |
| Smith & Co. (Carlisle) Limited | Wholesale & retail | 1988 |
| Smith Bros. Services Limited | Wholesale & retail | 1981 |
| Smith-Pyne Associates Ltd | Extraterritorial | 2021 |
| Smoke and Steel Ltd | Hospitality | 2021 |
| SN Allen Limited | Other services | 2026 |
| Sockbridge Hall Farming | Agriculture & fishing | 2011 |
| Softan Inspiration Limited | Information & communication | 2006 |
| Solar Solutions Cumbria Limited | Other services | 2022 |
| Solfit Limited | Construction | 2016 |
| Solfit Solar Services Ltd | Professional & scientific | 2026 |
| Solice Wellbeing Ltd | Other services | 2022 |
| Solo Sports Brands Limited | Wholesale & retail | 2011 |