| Solo Sports UK Holdings Limited | Professional & scientific | 2009 |
| Solviera Ltd | Wholesale & retail | 2025 |
| Song Bird Hospitality UK Ltd | Hospitality | 2024 |
| Soulands Studios Limited | Wholesale & retail | 2018 |
| South Dyke Farm | Administrative & support | 2012 |
| South Lonsdale Investments Limited | Real estate | 1959 |
| South West Wood Products Limited | Water & waste | 2009 |
| Southern Bliss Ltd | Professional & scientific | 2016 |
| Southport and Windsor Properties LLP | | 2004 |
| Southwaite Green Mill | Hospitality | 2017 |
| Space Designed Solutions Limited | Professional & scientific | 2003 |
| Spark Succession Partners Ltd | Financial services | 2024 |
| Spartan Systems Ltd | Information & communication | 2023 |
| Sperry Corporate Advisors Ltd | Extraterritorial | 2024 |
| Spin Cycle Shap Ltd | Other services | 2024 |
| Spittals Farm | Professional & scientific | 2010 |
| Sproat Body Repairs Ltd | Wholesale & retail | 2018 |
| SSC Medical Ltd | Wholesale & retail | 2021 |
| ST Johns Court (Keswick) Management Company Limited | Real estate | 2016 |
| ST Johns Street Keswick Property Limited | Real estate | 2024 |
| ST Patrick's Boat Landing Limited | Administrative & support | 2021 |
| Stacy Louise Ltd | Professional & scientific | 2016 |
| Staffield Hall Management Company Limited | Households | 1987 |
| Stainton Properties Ltd | Construction | 2019 |
| Stalker Construction Ltd | Construction | 2020 |
| Standing Oak Trades Limited | Administrative & support | 2021 |
| Station View Agricultural Store Limited | Transport & logistics | 2019 |
| Stay in Penrith Ltd | Hospitality | 2025 |
| Staynova Serviced Living Ltd | Hospitality | 2025 |
| Stellar Lion Limited | Wholesale & retail | 2020 |
| Stephead Enterprises Limited | Other services | 2025 |
| Stephen Mitchell Coaching Ltd. | Professional & scientific | 2004 |
| Stephen Nicol Associates Limited | Professional & scientific | 2015 |
| Steve Mossop Building Services Limited | Construction | 2008 |
| Sticky Wicket Beer Festivals Limited | Hospitality | 2013 |
| Stock Deli Ltd | Hospitality | 2025 |
| Stocksbridge Ltd | Real estate | 2024 |
| Stonefold Country Park Ltd | Hospitality | 2004 |
| Stoneleigh Communications Limited | Professional & scientific | 2008 |
| Stoneswood Developments Limited | Construction | 2016 |
| Stoneswood Homes Limited | Construction | 2017 |
| Storia Limited | Professional & scientific | 2010 |
| Stormcrow Limited | Information & communication | 2025 |
| Strategic Health and Performance Limited | Education | 2022 |
| Stratis Self Build Ltd | Construction | 2020 |
| Strength and Fitness Gym Ltd | Arts & recreation | 2021 |
| Strickland Properties Limited | Real estate | 2020 |
| Strictly Dental FIR Tree Limited | Health & social care | 2023 |
| Strictly Dental Limited | Health & social care | 2015 |
| Strictly Dental Practice Ltd | Health & social care | 2010 |
| Strutt Business Law Limited | Professional & scientific | 2021 |
| Stuart Oake Limited | Professional & scientific | 2003 |
| Study Monkey Ltd | Education | 2025 |
| Summerdale Caravan Park Limited | Hospitality | 2020 |
| Sums Machine Limited | Professional & scientific | 2015 |
| Sun and Leisure Centre (Penrith) Limited(The) | | 1983 |
| Sunny Brow (Holdings) Limited | Professional & scientific | 2007 |
| Surestep Mortgages Ltd | Financial services | 2023 |
| Sutton Property and Business Limited | Real estate | 2014 |
| SVL Hire Limited | Administrative & support | 2012 |
| SW Tyres & Valeting Limited | Wholesale & retail | 2020 |
| Swallows Rise Residents Management Company 2025 Limited | Households | 2025 |
| Swirral Accountants Limited | Professional & scientific | 2016 |
| SWQ Racing Limited | Arts & recreation | 2019 |
| SWS Services Limited | Administrative & support | 2016 |
| Synchronous Energy Limited | Energy | 2024 |
| Synora Lifesciences Limited | Professional & scientific | 2026 |
| T & Co Events Ltd | Hospitality | 2025 |
| T + D Services (UK) Ltd. | Construction | 2002 |
| T a Hodgson Limited | Construction | 2010 |
| T a O'Malley Ltd | Administrative & support | 2020 |
| T Boyes TM Ltd | Transport & logistics | 2024 |
| T C D Estates Investments Limited | Extraterritorial | 2019 |
| T C D Estates Limited | Construction | 2011 |
| T Norris Limited | Wholesale & retail | 2022 |
| T&F Plant Ltd | Construction | 2023 |
| T. E. Swainson Limited | Real estate | 1963 |
| T. J. Kemp Limited | Construction | 2008 |
| T.E.S. Property Limited | Real estate | 2001 |
| T.H. Relph Limited | Agriculture & fishing | 2003 |
| T.J. Furniture Limited | Wholesale & retail | 2007 |
| T.W. Relph & Sons Holdings Limited | Financial services | 2025 |
| T.W. Relph and Sons Limited | Wholesale & retail | 1985 |
| T4L Limited | Health & social care | 2009 |
| TAF Medical Ltd | Extraterritorial | 2023 |
| Tailored Spirits Company Limited | Wholesale & retail | 2018 |
| Talentyard Limited | Administrative & support | 2018 |
| Tamjen Civils and Hire Ltd | Construction | 2017 |
| Tangent Road Marking Limited | Construction | 1999 |
| Tarzan of Greystoke Ltd | Arts & recreation | 2017 |
| Tarzania Limited | Hospitality | 2010 |
| Tatton Holdco Limited | Financial services | 2025 |
| Tatton Services Limited | Professional & scientific | 2019 |
| Teachertutor.Org Ltd | Education | 2024 |
| Teal Advisory Limited | Professional & scientific | 2019 |
| Tebay Gorge Services Limited | Extraterritorial | 1972 |
| Tebay Motorway Services Limited | Extraterritorial | 2014 |
| Technical Outdoor Solutions Limited | Arts & recreation | 2009 |
| Technical Race Solutions Ltd | Administrative & support | 2020 |
| Tectum Meum Ltd | Hospitality | 2025 |