| Simplyextrajordanary Ltd | Professional & scientific | 2023 |
| Simpson Gore Limited | Administrative & support | 2007 |
| Simtek (International) Limited | Wholesale & retail | 2014 |
| Siner Inspection Services Ltd | Construction | 2023 |
| Sipevents Ltd | Hospitality | 2026 |
| Sirch Developments Limited | Construction | 1987 |
| Sirch Holdings Limited | Construction | 2017 |
| Sisashay Productions Ltd | Arts & recreation | 2021 |
| SJ Lifts Ltd | Manufacturing | 2011 |
| SJC Electrical Management Ltd | Construction | 2021 |
| SK Building Services (NW) Ltd | Construction | 2026 |
| SKA Travel Ltd | Administrative & support | 2025 |
| Skalptec Ltd | Health & social care | 2015 |
| Skia Designs Limited | Arts & recreation | 2011 |
| Skills in Focus Ltd | Education | 2015 |
| Skin Science Clinic Ltd | Other services | 2025 |
| Skvn Wellness Ltd | Health & social care | 2025 |
| Sky Recruitment and Care Services Ltd | Administrative & support | 2018 |
| Skyline Contract Fleet Services Ltd | Wholesale & retail | 2016 |
| Skyline Karting Ltd | Arts & recreation | 2019 |
| Skyline Leisure Ltd | Arts & recreation | 2019 |
| SL Property Management Limited | Real estate | 2025 |
| SLC (UK) Limited | Wholesale & retail | 2013 |
| Sled Residential Ltd | Real estate | 2026 |
| Sleep Liverpool Ltd | Administrative & support | 2015 |
| SM Fitness and Nutrition 333 Ltd | Health & social care | 2024 |
| Smart Leisure Supplies Ltd | Arts & recreation | 2025 |
| Smartthings Extras Limited | Information & communication | 2023 |
| SME Recover Ltd | Professional & scientific | 2023 |
| Smile Brands Ltd | Information & communication | 2007 |
| Smiths Materials Handling Solutions Ltd | Professional & scientific | 2025 |
| Smithy Mushrooms Holdings Limited | Financial services | 2018 |
| Smithy Mushrooms Limited | Agriculture & fishing | 1990 |
| Snack Runway Ltd | Wholesale & retail | 2026 |
| SND Services Limited | Transport & logistics | 2017 |
| Snowbone Limited | Administrative & support | 2005 |
| Snugglemelts Ltd | Manufacturing | 2025 |
| Snugglewood Farm Ltd | Agriculture & fishing | 2025 |
| SO Tasteful Limited | Manufacturing | 2022 |
| Softhard Ltd | Hospitality | 2026 |
| Solar ARC Limited | Professional & scientific | 2026 |
| Solmac Energy Limited | Administrative & support | 2005 |
| Solocomms Ltd | Information & communication | 2015 |
| Sologuard Products Ltd | Wholesale & retail | 2020 |
| Solutions Property Ltd | Real estate | 2008 |
| Somebody Nutrition Limited | Manufacturing | 2026 |
| Sonacape Group Ltd | Health & social care | 2018 |
| Sonix Standard Limited | Information & communication | 1998 |
| Sound Affects Music Ltd | Wholesale & retail | 2007 |
| Sound Affects Studios Limited | Information & communication | 2017 |
| Soundlad Liverpool Ltd | Manufacturing | 2022 |
| Source Exchange Ltd | Extraterritorial | 2012 |
| Southerner Couriers Ltd | Transport & logistics | 2025 |
| Southkirk Investments Limited | Administrative & support | 1964 |
| Southport Auto Centre Limited | Wholesale & retail | 2002 |
| Southport Decor Ltd | Construction | 2013 |
| Southport FLY Fishers Limited | Agriculture & fishing | 2023 |
| Southport Kitchens and Bathrooms Ltd | Construction | 2018 |
| Southport Lettings Limited | Real estate | 2016 |
| Spacelets Limited | Real estate | 2025 |
| Spare Property Ltd | Real estate | 2025 |
| Specialist Business Training Limited | Education | 2025 |
| Specialist Paediatric Occupational Therapy Limited | Health & social care | 2023 |
| Specialist Taxation Services (Europe) Limited | Professional & scientific | 2018 |
| Spectrum Cleaning Limited | Administrative & support | 2021 |
| Spectrum Coatings Limited | Manufacturing | 2017 |
| Spencer & Harrison Properties Ltd | Real estate | 2025 |
| Spice Island Indonesia Ltd | Manufacturing | 2025 |
| SPINALHEALTH4ALL Ltd | Health & social care | 2012 |
| Spitfire Heritage Distillers Limited | Wholesale & retail | 2016 |
| Splashpool Chemicals Ltd | Manufacturing | 2025 |
| Square Joinery Ltd | Extraterritorial | 2025 |
| Squires Park Property LLP | | 2021 |
| Squires Trading Ltd | Real estate | 2022 |
| SR Building & Construction Limited | Construction | 2017 |
| SR Investments Ormskirk Limited | Real estate | 2018 |
| Sruu Private Limited | Health & social care | 2023 |
| SSG Collective Ltd | Professional & scientific | 2025 |
| ST Clifton Holdings Ltd | Households | 2019 |
| ST Mary’S Court (Burry Port) Apartments Ltd | Real estate | 2023 |
| ST. Mary's Launderette Limited | Other services | 1982 |
| Stapleton Derby Limited | Real estate | 2004 |
| Starnthwaite Ghyll Management Company Limited | Households | 1984 |
| Station House Nursery School Limited | Health & social care | 2021 |
| Steel Empire Ltd | Manufacturing | 2023 |
| Stellar Strategies Ltd | Information & communication | 2022 |
| Steph the Estate Agent Ltd | Real estate | 2025 |
| Stephen Brown Keswick Limited | Administrative & support | 2013 |
| Sterling Material Handling Limited | Manufacturing | 2003 |
| Steve Banks & Partners Limited | Administrative & support | 2022 |
| Steve Green Electrical Limited | Construction | 2015 |
| Stockton Students Limited | Real estate | 2021 |
| Stones Flooring and Carpets Ltd | Wholesale & retail | 2025 |
| Storr Consulting Limited | Professional & scientific | 2026 |
| Stratco Advisory Limited | Wholesale & retail | 2021 |
| Strategic Management (UK) Limited | Professional & scientific | 2011 |
| Stratosphere Research Limited | Administrative & support | 2012 |
| Stratospheric Ltd | Information & communication | 2020 |
| Streete&Co Ltd | Real estate | 2025 |
| Strictly Golf Ltd | Wholesale & retail | 2021 |