| Safety Solutions North West Limited | Construction | 2003 |
| Sahara 2 Ormskirk Ltd | Hospitality | 2023 |
| Saint Clifton Limited | Real estate | 2020 |
| Saint JAX Limited | Hospitality | 2025 |
| Saints Community Sports CIC | Education | 2025 |
| Salamander (Engineering) Limited | Manufacturing | 1980 |
| Salder Limited | Extraterritorial | 1992 |
| Sales Training International Limited | Professional & scientific | 2003 |
| Salisbury Gallbladder Surgery Ltd | Health & social care | 2022 |
| Sally Nicholson Ltd | Health & social care | 2019 |
| Salmon Marketing Limited | Professional & scientific | 2013 |
| Salon One Hair & Beauty Limited | Other services | 2018 |
| Salt PIT Croft Farm Ltd | Agriculture & fishing | 2014 |
| Saltmarsh Estates Ltd | Administrative & support | 2017 |
| SAM Ellis Limited | Information & communication | 2022 |
| Sam's Property Maintenance Ltd | Construction | 2025 |
| Samantha Lang Limited | Other services | 2019 |
| Samuel Joseph Site Services Ltd | Construction | 2024 |
| Santana Limited | Hospitality | 2025 |
| Sapphire IT Solutions Ltd | Information & communication | 2024 |
| Satis Properties Limited | Real estate | 2014 |
| Saturnlighting Ltd | Manufacturing | 2025 |
| Saul's Joinery Ltd | Construction | 2025 |
| Sawyer Quine & Co Limited | Professional & scientific | 2011 |
| SB Pets Ltd | Wholesale & retail | 2023 |
| SB Web Services Ltd | Wholesale & retail | 2021 |
| SBH Dental Ltd | Health & social care | 2024 |
| Sbuk Hosting Ltd | Hospitality | 2025 |
| SC Atkinson Investments Ltd | Real estate | 2024 |
| Scallyz Limited | Wholesale & retail | 2024 |
| Scarisbrick Business Park Management Company Limited | Extraterritorial | 2008 |
| Scarisbrick Community and School Transport Limited | Transport & logistics | 2010 |
| Scarisbrick Hall and School Ltd | Education | 2012 |
| Scarisbrick Hall Developments Limited | Construction | 2006 |
| Scarisbrick Hall Holdings Limited | Professional & scientific | 2009 |
| Scarisbrick Hall Limited | Agriculture & fishing | 2006 |
| Scarisbrick Hall School Limited | Education | 2009 |
| Scarisbrick Hall Transport Limited | Transport & logistics | 2007 |
| Scarisbrick Hall Trust | Education | 2007 |
| Scarisbrick Marina Limited | Arts & recreation | 1992 |
| Scartworks Limited | Arts & recreation | 2002 |
| Schemeglobal Properties (Southport) Limited | Construction | 2010 |
| School Lane Farm Limited | Transport & logistics | 2016 |
| School of Stitched Textiles Limited | Education | 2006 |
| Scott's Automotive Limited | Wholesale & retail | 2025 |
| Scotty's Pies Ltd | Manufacturing | 2023 |
| Scrumchies Limited | Manufacturing | 2017 |
| SDS Accountancy Limited | Professional & scientific | 2024 |
| SE Solutions Limited | Wholesale & retail | 2023 |
| SE Wind Ltd | Professional & scientific | 2025 |
| Sea Sea DM Ltd | Information & communication | 2026 |
| Seafire Business Park Management Company Ltd | Extraterritorial | 2021 |
| Second Glance Theatre CIC | Arts & recreation | 2023 |
| Secore Limited | Administrative & support | 2014 |
| Secure Web Solutions Ltd | Administrative & support | 2026 |
| Seddon & Sons (Produce) Ltd | Agriculture & fishing | 2010 |
| Sefton Fire Protection Ltd | Professional & scientific | 2003 |
| Sefton House RTM Company Limited | Households | 2015 |
| Select Cell Ltd | Information & communication | 2018 |
| Select CM Limited | Professional & scientific | 2019 |
| Select Windows (North West) Limited | Construction | 2012 |
| Selez Limited | Hospitality | 2023 |
| Selini Jewellery Ltd | Wholesale & retail | 2009 |
| Seminar Intelligence Ltd | Administrative & support | 2025 |
| Sentigrow Ltd | Information & communication | 2013 |
| SEP (Site Engineering Personnel) Limited | Professional & scientific | 1986 |
| SEP Engineers Limited | Professional & scientific | 2019 |
| SEP Geospatial Limited | Construction | 2019 |
| SEP Land & Developments Ltd | Construction | 2019 |
| SEP Professional Services Holdings Ltd | Financial services | 2021 |
| SEP Professional Services Limited | Professional & scientific | 2016 |
| SEP Resource Solutions Limited | Administrative & support | 2019 |
| SEP Technical Limited | Professional & scientific | 2019 |
| Sephton Investment Properties Limited | Real estate | 2025 |
| Septtgoods Ltd | Wholesale & retail | 2023 |
| Sewing Street Limited | Wholesale & retail | 2014 |
| SFH UK Holdings Limited | Financial services | 2023 |
| Shad Fork Trucks (Liverpool) Limited | Wholesale & retail | 1976 |
| Shamraat 2 Limited | Hospitality | 2024 |
| Sharp Curve Ltd | Information & communication | 2020 |
| Sharper Pools Ltd | Construction | 2021 |
| Shaw Properties (NW) Ltd | Real estate | 2022 |
| Shawcare Limited | Health & social care | 2008 |
| Shayan Food Store Ltd | Wholesale & retail | 2023 |
| Shelka Ltd | Real estate | 2014 |
| Shemworld Limited | Hospitality | 1998 |
| Shevington Electrical Services Ltd | Construction | 2015 |
| SHG Homes Ltd | Construction | 2017 |
| Shoot ME Down Limited | Wholesale & retail | 2006 |
| Shoreside Trading Limited | Other services | 2019 |
| SHOUT99 Limited | Information & communication | 2003 |
| Shubd Company Limited | Wholesale & retail | 2018 |
| Sikarus Real Estate Limited | Real estate | 2025 |
| Silike (UK) Limited | Administrative & support | 2002 |
| Silverstone Leisure Limited | Other services | 2018 |
| Silverthorn UK Limited | Transport & logistics | 2002 |
| Simmons Consultants Limited | Professional & scientific | 2014 |
| Simon the Beekeeper Ltd | Wholesale & retail | 2023 |
| Simplaw Ltd | Administrative & support | 2011 |
| Simplex Piling Limited | Extraterritorial | 2001 |