| Redefined Care Ltd | Health & social care | 2025 |
| REDSTAR9 Limited | Wholesale & retail | 2021 |
| Refill My Candles Ltd | Wholesale & retail | 2018 |
| Refined Marketing Agency Limited | Professional & scientific | 2019 |
| Reflex Building Services Ltd | Construction | 2011 |
| Regal Facilities MGT Limited | Real estate | 2025 |
| Regal Ormskirk Construction Limited | Construction | 2014 |
| Regal Ormskirk Limited | Real estate | 2017 |
| Reid Deveopments Ltd | Construction | 2026 |
| Reid Property Group Limited | Real estate | 2017 |
| Renflex Limited | Other services | 2019 |
| Renter FIX Limited | Real estate | 2014 |
| Rentons Garages Limited | Financial services | 1947 |
| Repo Clothing Ltd | Wholesale & retail | 2024 |
| Rescue Equine Showing Society Limited | Arts & recreation | 2023 |
| Research and Development Group Ltd | Extraterritorial | 2022 |
| Resonanz Records Limited | Information & communication | 2026 |
| Respond & Recover Ltd | Administrative & support | 2023 |
| Rest Ashored Ltd | Financial services | 2012 |
| Retailwise UK Limited | Extraterritorial | 2014 |
| Reuben James Consultants Ltd | Information & communication | 2022 |
| Reubens Paws & Gifts Ltd | Wholesale & retail | 2025 |
| Revalric Ltd | Information & communication | 2020 |
| RG Loftconversions & Extensions Ltd | Manufacturing | 2019 |
| RGL Martial Arts Limited | Arts & recreation | 2016 |
| RH Driving Ltd | Transport & logistics | 2019 |
| RHP3 Limited | Construction | 2014 |
| Ribcar (Liverpool) Limited | Administrative & support | 1954 |
| Riley's Stoves & Sweeps Ltd | Construction | 2022 |
| Ringtail Engineering Limited | Manufacturing | 1995 |
| Ringtail Garage Limited | Wholesale & retail | 2002 |
| Ringwood Timber Limited | Manufacturing | 2021 |
| Rishik Healthcare Ltd | Health & social care | 2024 |
| Riversdale Finance Limited | | 2009 |
| RJ Anderton Limited | Professional & scientific | 2010 |
| RKH Investments Limited | Other services | 2018 |
| RLJ Media Ltd | Information & communication | 2021 |
| RLS Residential Letting Solutions Limited | Real estate | 2024 |
| RM Daly Electrical Services Ltd | Construction | 2020 |
| RM Dental Limited | Health & social care | 2022 |
| RM Gibbons Fabrications Limited | Construction | 2020 |
| RM Gibbons Ltd | Construction | 2011 |
| Rmje Limited | Real estate | 2023 |
| Roadie Investments Limited | Real estate | 2017 |
| Robin Advisory Limited | Professional & scientific | 2025 |
| Robins Bridge Nursery Ltd | Wholesale & retail | 2013 |
| Robinson Automate Limited | Construction | 2022 |
| Robinson Dean Construction Limited | Construction | 2020 |
| Robot Automation Ltd | Information & communication | 2017 |
| Roby One Consulting Limited | Administrative & support | 2020 |
| Rock and River Outdoor Pursuits Limited | Arts & recreation | 2009 |
| Rockbarn Ltd | Real estate | 2024 |
| Rocketfox Limited | Administrative & support | 2024 |
| Roger Over Ltd | Professional & scientific | 2015 |
| Rojo Live Limited | Hospitality | 2023 |
| Romanesque Properties Limited | Construction | 2001 |
| Roocroft Holdings Limited | Information & communication | 2000 |
| Rookyard Consultancy Limited | Information & communication | 2021 |
| Rose & Co. Homes Limited | Real estate | 2024 |
| Rose Hall Trading Limited | Wholesale & retail | 2016 |
| Rose Hart Limited | Other services | 2010 |
| Rothland Limited | Transport & logistics | 1991 |
| Rotunda Group Limited | Professional & scientific | 1996 |
| Rotunda Waste Limited | Water & waste | 2013 |
| Rowanberry Limited | Other services | 2001 |
| Rowelay Flooring Limited | Construction | 2004 |
| ROZ Tranfield Beauty Centre Limited | Other services | 2003 |
| RP Property Services NW Limited | Real estate | 2024 |
| RPG Property NW Limited | Real estate | 2025 |
| RT Maintenance Ltd | Construction | 2024 |
| RT Risk Consulting Limited | Financial services | 2008 |
| Ruff Lane Day Nursery Limited | Health & social care | 2013 |
| Ruff LEA Farm Limited | Wholesale & retail | 2003 |
| Rufford Computer Services Ltd | Information & communication | 2010 |
| Rufford Freehold Property Company Limited | Real estate | 2010 |
| Rufford's Stores Limited | Wholesale & retail | 2018 |
| RUNG2 Limited | Real estate | 2023 |
| Runway Car & Commercial Limited | Wholesale & retail | 2023 |
| Rural Telecoms Limited | Information & communication | 2021 |
| Róandi Estates Ltd | Real estate | 2023 |
| S & W Horticulture Ltd | Agriculture & fishing | 2017 |
| S Fletcher Design & Build Ltd | Construction | 2013 |
| S Gilligan Consultancy Limited | Other services | 2020 |
| S M P Design (Northern) Limited | Professional & scientific | 1998 |
| S Thomson Joinery Ltd | Construction | 2026 |
| S&D Property NW Limited | Real estate | 2025 |
| S&J Wright Ltd | Financial services | 2023 |
| S. & D. Ireland Ltd | Wholesale & retail | 2007 |
| S. Heapy Motor Engineering Ltd | Wholesale & retail | 2025 |
| S. Moss & Co Ltd | Real estate | 2026 |
| S.A Leisure Limited | Wholesale & retail | 2024 |
| S.A.M Homes Ltd | Real estate | 2015 |
| S.O. Urology Limited | Health & social care | 2019 |
| S.W.E.L Well-Being Limited | Administrative & support | 2026 |
| S1 Executive Travel Ltd | Extraterritorial | 2024 |
| SA Mawdsley Ltd | Construction | 2023 |
| Sabrina's Mortgages and Protection Limited | Financial services | 2024 |
| Sacom Next Generation Limited | Information & communication | 2012 |
| Sacs Property Services Limited | Other services | 2017 |
| Safe Haven Investments Limited | Real estate | 2017 |