| Shekinah Health Ltd | Wholesale & retail | 2024 |
| Shenton Consultancy Ltd | Professional & scientific | 2014 |
| Shenzhen JMD Ltd | Wholesale & retail | 2025 |
| Shepley Gardens Management Company Limited | Real estate | 2017 |
| Sherazi Exports Limited | Public administration | 2025 |
| Sherazi Limited | Health & social care | 2021 |
| Sherbrooke House Marketing 1981 Ltd | Professional & scientific | 2025 |
| Sheridan Care Limited | Health & social care | 2005 |
| Sherilyn Evans Styling Limited | Professional & scientific | 2009 |
| Sherman Homes Ltd | Real estate | 2024 |
| Sherserenity Ltd | Wholesale & retail | 2023 |
| Sherwoods Safety UK Limited | Professional & scientific | 2023 |
| Shiels Building Consultancy Ltd | Construction | 2024 |
| Shiels Design Ltd | Construction | 2019 |
| Shifaz Limited | Wholesale & retail | 2025 |
| Shiftgear Motors Ltd | Wholesale & retail | 2025 |
| Shiloh Farm Ltd | Agriculture & fishing | 2024 |
| Shiloh Springs Ltd | Real estate | 2025 |
| Shine a Light Day Nursery Ltd | Health & social care | 2019 |
| Shine a Light Recruitment Ltd | Administrative & support | 2021 |
| Shine Fairy Ltd | Administrative & support | 2022 |
| Shine Flex UK Limited | Wholesale & retail | 2024 |
| Shining North CIC | Health & social care | 2025 |
| Ship Buddy Limited | Transport & logistics | 2026 |
| Shipify Ltd | Wholesale & retail | 2025 |
| Shipnshare Ltd | Wholesale & retail | 2026 |
| Shipp Debt Recovery Ltd | Administrative & support | 2025 |
| Shipp Intellectual Property Ltd | Administrative & support | 2021 |
| Shire Manchester Limited | Real estate | 2018 |
| Shires Barnes Limited | Other services | 2020 |
| Shires View Management Company Ltd | Households | 2008 |
| Shirtox Ltd | Wholesale & retail | 2025 |
| Shishu Miah & Sons Properties Ltd | Real estate | 2024 |
| Shiznit Engineering Ltd | Manufacturing | 2025 |
| Shkarex Ltd | Wholesale & retail | 2019 |
| Shoaib ALI Limited | Wholesale & retail | 2025 |
| Shoetex Trading Ltd | Wholesale & retail | 2020 |
| Shonach Ltd | Real estate | 2026 |
| Shop N Tale Ltd | Information & communication | 2017 |
| Shop NEX Limited | Wholesale & retail | 2025 |
| Shopexpres Ltd | Wholesale & retail | 2021 |
| Shopifactor International Ltd | Wholesale & retail | 2018 |
| Shopnest.Pk Ltd | Wholesale & retail | 2025 |
| Shopnix Group Ltd | Wholesale & retail | 2025 |
| Shopping Box Ltd | Wholesale & retail | 2025 |
| Shoppio Ltd | Wholesale & retail | 2025 |
| Short Bark and Sides (NW) Ltd | Other services | 2021 |
| Show Motion Media Ltd | Information & communication | 2018 |
| Showman's Investments | Financial services | 2022 |
| Shreehotto Limited | Hospitality | 2020 |
| SHS Healthcare Ltd | Health & social care | 2022 |
| SHS Mini Market Ltd | Wholesale & retail | 2026 |
| Shuja International Ltd | Wholesale & retail | 2022 |
| Shuks Automobili Ltd | Wholesale & retail | 2024 |
| Shuttleworth Installations Ltd | Construction | 2025 |
| SI GAS Heating Ltd | Construction | 2024 |
| SI Lawyers Ltd | Administrative & support | 2018 |
| SI Motor Group Ltd | Wholesale & retail | 2025 |
| SIA Silk Ltd | Wholesale & retail | 2023 |
| Siamber Limited | Real estate | 2022 |
| Siantech Ltd | Information & communication | 2021 |
| Sibrat Care Limited | Other services | 2016 |
| SID Painting Contrator Ltd | Other services | 2022 |
| Siddall Sunrise Developments Ltd | Real estate | 2024 |
| Siddique Bros Ltd | Wholesale & retail | 2024 |
| Siddique Logistics Ltd | Wholesale & retail | 2025 |
| Sidra Daood Ltd | Health & social care | 2023 |
| Sidtas Ltd | Real estate | 2025 |
| SIG Comm Digital Limited | Other services | 2010 |
| Sigma 7 Ltd | Wholesale & retail | 2023 |
| Sigma Financial Ltd | Financial services | 2024 |
| Sigma Trading MCR Ltd | Wholesale & retail | 2026 |
| Sign UK Holdings Limited | Administrative & support | 2015 |
| Sign UK Limited | Manufacturing | 2007 |
| Signature Drive Ltd | Transport & logistics | 2026 |
| Signature Group MCR Limited | Wholesale & retail | 2025 |
| Signature Moments Ltd | Hospitality | 2023 |
| Signature Shots Ltd | Manufacturing | 2019 |
| Signet Travel Ltd | Professional & scientific | 2026 |
| SIGNUM4 Limited | Manufacturing | 2007 |
| Sigram Flue Systems Limited | Manufacturing | 1969 |
| Silc Landscaping Ltd | Administrative & support | 2024 |
| Silcock D Limited | Wholesale & retail | 2017 |
| Silent Ninja Ltd | Information & communication | 2026 |
| Silex (North West) Limited | Construction | 2011 |
| Silhouette Hair Ltd | Other services | 2018 |
| Silkcourt Limited | Households | 1990 |
| Sill-O-Ette Curtains & Blinds Ltd | Manufacturing | 2020 |
| Silver Estates Ltd | Real estate | 2026 |
| Silver Falcon Maintenance Ltd | Construction | 2026 |
| Silver Lining Homes Ltd | Administrative & support | 2024 |
| Silver Star Services Limited | Construction | 1998 |
| Silverama Limited | Administrative & support | 2005 |
| Silverlane Developments (BTR1) Ltd | Construction | 2024 |
| Silverlane Developments Special Projects Ltd | Construction | 2024 |
| Silverline 9900 Ltd | Administrative & support | 2020 |
| Silverstone 100 Ltd | Administrative & support | 2022 |
| Silverstone Assessors Ltd | Professional & scientific | 2011 |
| Silverstone Imports Ltd | Manufacturing | 2024 |
| Silverthread Ventures Ltd | Wholesale & retail | 2025 |