| Silvertree Financial Services Ltd | Professional & scientific | 2022 |
| Sima Foods Ltd | Wholesale & retail | 2026 |
| Simarni Ltd | Arts & recreation | 2021 |
| Simbifi Ltd | Real estate | 2022 |
| Simeon Oluwole Limited | Wholesale & retail | 2017 |
| Simi Innocent Limited | Health & social care | 2018 |
| Simisiwe Limited | Health & social care | 2016 |
| Simon Waters Limited | Extraterritorial | 2022 |
| Simple Branding and Consultancy Limited | Administrative & support | 2025 |
| Simple Caring Ltd | Health & social care | 2025 |
| Simplex Homecare Ltd | Health & social care | 2016 |
| Simpli Green Ltd | Construction | 2020 |
| Simplibuy Ltd | Wholesale & retail | 2025 |
| Simplicity Events Limited | Other services | 2006 |
| Simplifysme Ltd | Information & communication | 2026 |
| Simply Crispy Ltd | Hospitality | 2023 |
| Simply Fish & Chips Ltd | Hospitality | 2014 |
| Simply Fish and Chips Chadderton Ltd | Hospitality | 2026 |
| Simply Fresh Dining Ltd | Hospitality | 2024 |
| Simply Fresh Oldham Ltd | Hospitality | 2025 |
| Simply Fresh Takeaway Ltd | Hospitality | 2018 |
| Simply Indian Ltd | Wholesale & retail | 2017 |
| Simply Signs (NW) Ltd | Administrative & support | 2009 |
| Simply Skin Oldham Limited | Administrative & support | 2016 |
| Simra's Fashion UK Ltd | Wholesale & retail | 2018 |
| Sincere Management Accountants Ltd | Professional & scientific | 2022 |
| Sinclair Accountants Ltd | Professional & scientific | 2019 |
| Sinclair Auto Specialists Ltd | Wholesale & retail | 2020 |
| Sinclair Newcastle Properties Limited | Real estate | 2026 |
| Sinclair Prestige Hub Ltd | Wholesale & retail | 2019 |
| Sindsley Manor Developments Limited | Households | 2004 |
| Singlemorn UK Limited | Wholesale & retail | 2018 |
| Sinit Healthcare Ltd | Wholesale & retail | 2024 |
| Sipfix UK Ltd | Manufacturing | 2012 |
| Sireen Fashion Limited | Wholesale & retail | 2025 |
| Siri Marquees Limited | Administrative & support | 2026 |
| Sirius Homes MCR Ltd | Real estate | 2023 |
| Siscp Ltd | Health & social care | 1997 |
| Site Contract Investments Limited | Financial services | 2019 |
| Site Contract Personnel Limited | Administrative & support | 2010 |
| Site Engineer Manchester Limited | Construction | 2017 |
| Site Installation Services (UK) Limited | Administrative & support | 2006 |
| Site Welding & Fabrication Services (UK) Limited | Construction | 2014 |
| Site Welding Fabrications Limited | Manufacturing | 2007 |
| Sitepartner Limited | Real estate | 2001 |
| Sitsafe in Car Safety Ltd | Wholesale & retail | 2018 |
| SIVEK21 Ltd | Transport & logistics | 2021 |
| SIXTY3 Holdings Limited | Real estate | 2025 |
| SIZ Solutions North Limited | Wholesale & retail | 2022 |
| Sizzle in Grill Ltd | Hospitality | 2023 |
| Sizzlers Oldham Ltd | Hospitality | 2024 |
| Sizzling Bites Ltd | Hospitality | 2017 |
| SJ & ZJ Limited | Professional & scientific | 2024 |
| SJ Marks Ltd | Wholesale & retail | 2020 |
| SJ Motor Services Ltd | Other services | 2020 |
| SJ Signs & Graphixs Limited | Other services | 2025 |
| SJB Electrical Solutions Ltd | Construction | 2025 |
| SJC Driver Training Ltd | Education | 2025 |
| SJH Building Maintenance Ltd | Administrative & support | 2026 |
| SJL39 Ltd | Information & communication | 2013 |
| SJS Switchgear Services Limited | Energy | 2014 |
| SK Dental Aesthetics Limited | Health & social care | 2026 |
| SK Developments Group Ltd | Construction | 2025 |
| SK Foundation Ltd | Health & social care | 2023 |
| SK Jatti Limited | Wholesale & retail | 2025 |
| SK Legal Services Ltd | Professional & scientific | 2014 |
| SK Shah Optics Ltd | Health & social care | 2024 |
| SK Taxis PVT Limited | Wholesale & retail | 2025 |
| Sk.Pt Ltd | Other services | 2020 |
| SK8 Modular Ltd | Construction | 2025 |
| SKA Properties U.K. Ltd | Real estate | 2025 |
| Ska-Elektro Ltd | Construction | 2023 |
| SKD Consultants Ltd | Construction | 2011 |
| SKI Bookkeepers Ltd | Professional & scientific | 2015 |
| Skidzy Networks Ltd | Information & communication | 2025 |
| Skill Match Staffing Ltd | Administrative & support | 2025 |
| Skin Revive Clinic Ltd | Health & social care | 2016 |
| Skin Solutions Clinic Ltd | Health & social care | 2025 |
| Skin TEK Solutions UK Limited | Other services | 2024 |
| Skinfull Ltd | Arts & recreation | 2025 |
| SKN+ Limited | Other services | 2025 |
| Skolar Education UK Limited | Education | 2022 |
| Skool Camp (Manchester) Limited | Health & social care | 2010 |
| SKT Apparel Limited | Wholesale & retail | 2022 |
| Sky Dweller Performance Ltd | Administrative & support | 2023 |
| Sky Properties Manchester Ltd | Households | 2022 |
| Skybolt Industries Ltd | Manufacturing | 2019 |
| Skyclad Aerostructures Ltd | Manufacturing | 2019 |
| Skycover Limited | Construction | 2026 |
| Skyeoban Ltd | Professional & scientific | 2021 |
| Skylight Express Limited | Transport & logistics | 2025 |
| Skyline Oldham Property Limited | Real estate | 2026 |
| Skypiea Pharma Ltd | Wholesale & retail | 2024 |
| Skyraid Drones Ltd | Professional & scientific | 2026 |
| Skyward Flight Training Limited | Education | 2012 |
| Skyworld Travel Group Ltd | Administrative & support | 2024 |
| Sky’S Equine Supplies Ltd | Wholesale & retail | 2026 |
| SL Civils Ltd | Construction | 2024 |
| SL Hire and Storage Limited | Other services | 2023 |
| SLA Maths Ltd | Education | 2024 |