| Scott Booth Design Ltd | Professional & scientific | 2013 |
| Scott Rayner Investments Ltd | Real estate | 2026 |
| Scott Rayner Sourcing Limited | Administrative & support | 2025 |
| Scowcroft House Management Company Limited | Households | 2002 |
| SCP Rail Limited | Administrative & support | 2019 |
| Scps Group Limited | Financial services | 2026 |
| Scrap Car Guys Ltd | Wholesale & retail | 2025 |
| Scrap Car Guys MCR Ltd | Wholesale & retail | 2026 |
| Screw Media Ltd | Information & communication | 2014 |
| Scruples Academy Limited | Extraterritorial | 2014 |
| SCS Homecare Ltd | Public administration | 2018 |
| SCT Climbing Limited | Arts & recreation | 2017 |
| Scytheplays Ltd | Arts & recreation | 2014 |
| SD Globe Limited | Manufacturing | 2018 |
| SD Group Construction Ltd | Construction | 2022 |
| SD Group Holdco Limited | Financial services | 2026 |
| SD Group Properties Limited | Real estate | 2026 |
| SD Matrix Management Limited | Real estate | 2015 |
| SD Season Limited | Wholesale & retail | 2025 |
| SDG Engineering Services Ltd | Professional & scientific | 2018 |
| Sdhart Ltd | Professional & scientific | 2024 |
| SDW Travel Ltd | Administrative & support | 2023 |
| SE Roofing & Building Ltd | Construction | 2024 |
| Seacare Compass (C & D) Limited | Hospitality | 2018 |
| Seacare Compass Aberdeen Limited | Hospitality | 2021 |
| Seacare Compass Dundee Limited | Hospitality | 2017 |
| Seacare Compass Ilfracombe Limited | Hospitality | 2022 |
| Seacare Compass Manchester Limited | Hospitality | 2015 |
| Seacare Compass Perth Limited | Hospitality | 2021 |
| Seacare Compass Portpatrick Limited | Hospitality | 2023 |
| Seacare Compass Scarborough Limited | Hospitality | 2024 |
| Seacare Hospitality (UK) Limited | Financial services | 2015 |
| Seacare Inverness Limited | Hospitality | 2016 |
| Seacare Leeds Limited | Hospitality | 2016 |
| Seacare Scarborough Limited | Hospitality | 2017 |
| Seal Trading Lettings Limited | Real estate | 2018 |
| Seamaster Sailing Ltd | Wholesale & retail | 2009 |
| Seamless Design Studios Ltd | Professional & scientific | 2025 |
| Search Time Recruitment Ltd | Administrative & support | 2016 |
| Search Tutor Ltd | Education | 2020 |
| Seasons (North West) Limited | Professional & scientific | 2016 |
| Seat & Skoda Audi VW Breakers Ltd | Wholesale & retail | 2025 |
| Secmite IG Limited | Manufacturing | 2024 |
| Second Time Around Furnishings Limited | Wholesale & retail | 2018 |
| Secor Group Ltd | Transport & logistics | 2024 |
| Secret Burger Ltd | Hospitality | 2020 |
| Secret House Escapes Ltd | Hospitality | 2024 |
| Secure Box Self Storage Limited | Transport & logistics | 2024 |
| Secure Cyber Ltd | Information & communication | 2019 |
| Secure Installation & Alarm Maintenance Ltd | Manufacturing | 2014 |
| Secure MCR Ltd | Construction | 2026 |
| Secure Store FM Limited | Construction | 2015 |
| Secure Store Limited | Information & communication | 2021 |
| Secureaxs Ltd | Information & communication | 2019 |
| Securitex Ltd | Wholesale & retail | 2022 |
| Security Equipment Rentals Ltd | Administrative & support | 2024 |
| SEE (Juniors) CIC | Education | 2024 |
| SEE (Oldham) CIC | Education | 2022 |
| Seedhouseplants Ltd | Wholesale & retail | 2022 |
| Seedling Global Limited | Information & communication | 2023 |
| Seemed Healthcare Ltd | Wholesale & retail | 2007 |
| Seerah Group Limited | Other services | 2023 |
| Seftons (Ashton) Limited | Professional & scientific | 2014 |
| Seftons Consulting Ltd | Professional & scientific | 2014 |
| Seftons Holdings Limited | Financial services | 2021 |
| Seftons Limited | Professional & scientific | 2006 |
| Sefu Limited | Hospitality | 2025 |
| Segfolks Logistics Ltd | Transport & logistics | 2024 |
| Selah Trades Ltd | Financial services | 2025 |
| Select Building & Surveying Services Limited | Wholesale & retail | 2004 |
| Select Cloud Solutions Limited | Information & communication | 2022 |
| Select Locum Limited | Health & social care | 2022 |
| Selftec Ltd | Other services | 2024 |
| Selfus UK Ltd | Wholesale & retail | 2026 |
| Sell Car Manchester Ltd | Wholesale & retail | 2021 |
| Sella-Askus Engineering Limited | Manufacturing | 2008 |
| Sellins Ltd | Wholesale & retail | 2024 |
| Sellis Hair Ltd | Other services | 2026 |
| Semi Independent Provisions Ltd | Health & social care | 2017 |
| Semonperez Ltd | Other services | 2003 |
| Senator Holdings Ltd | Real estate | 2019 |
| Senator Trading Ltd | Hospitality | 2019 |
| Send Consultancy Services Limited | Education | 2022 |
| Senedix Limited | Extraterritorial | 2021 |
| Senorita Ltd | Wholesale & retail | 2021 |
| Senses Spa Ltd | Other services | 2025 |
| Sensory Hearing Ltd | Health & social care | 2021 |
| Sentinel Self Storage Ltd | Real estate | 2014 |
| Sepia Homes Ltd | Households | 2022 |
| Septic AI Limited | Wholesale & retail | 2025 |
| Sequential Services Limited | Hospitality | 2019 |
| Seraphic Chambers Ltd | Health & social care | 2024 |
| Serencyon Limited | Information & communication | 2014 |
| Serene Trading Ltd | Wholesale & retail | 2024 |
| Serenity 365 Limited | Hospitality | 2024 |
| Serenity NW Ltd | Real estate | 2023 |
| Service Intermediation Ltd. | Wholesale & retail | 2020 |
| Service Wash Express Ltd | Other services | 2008 |
| SERVICE-24 Ltd. | Financial services | 2014 |
| Services Express Limited | Transport & logistics | 2025 |