| Samsor Ltd | Wholesale & retail | 2019 |
| Samstead Limited | Real estate | 2024 |
| Samuel Howarth Limited | Wholesale & retail | 1976 |
| SAN Construction (Mossley) Ltd | Construction | 2017 |
| SAN Enterprise Trading Limited | Wholesale & retail | 2020 |
| Sana House Limited | Manufacturing | 2018 |
| Sanats Cleaning Limited | Administrative & support | 2025 |
| Sana’S Hair Studio Ltd | Other services | 2024 |
| Sanctuary Gym & Fitness Limited | Arts & recreation | 2020 |
| Sand (UK) Limited | Wholesale & retail | 1998 |
| Sandfield Cleaning Services Ltd | Administrative & support | 2016 |
| Sandhill Securities Limited | Information & communication | 2021 |
| Sandpipers (Stratford on Avon) Management Company Limited | Households | 2007 |
| Sands Nutrition Ltd | Wholesale & retail | 2019 |
| Sandstone Property Investments Ltd | Real estate | 2022 |
| Sania Sweets & Bakers Limited | Hospitality | 2018 |
| Saniyashafique Ltd | Health & social care | 2026 |
| Santa's Village Entertainment Limited | Wholesale & retail | 2018 |
| Santamaria Europe Ltd | Wholesale & retail | 2019 |
| Santiago Enterprises Ltd | Wholesale & retail | 2018 |
| Santos Kebab 2 Ltd | Hospitality | 2025 |
| Sanya Optics Ltd | Health & social care | 2025 |
| Sapience Girls Academy Ltd | Education | 2023 |
| Sapphire N Beauty Ltd | Wholesale & retail | 2019 |
| Saqi's Takeaway Limited | Hospitality | 2026 |
| Saqib Khan Estates Limited | Real estate | 2017 |
| Saqib Khan Holdings Limited | Professional & scientific | 2017 |
| SAR Textiles Ltd | Wholesale & retail | 2020 |
| Saracen Motors Ltd | Wholesale & retail | 2025 |
| Sarah Anne Properties Limited | Extraterritorial | 2020 |
| Sarah NYE Limited | Professional & scientific | 2023 |
| Sarah's Childcare Hub Limited | Health & social care | 2022 |
| Saraha Ltd | Wholesale & retail | 2017 |
| Saras Process Limited | Manufacturing | 2003 |
| Sarcon Surveys Limited | Professional & scientific | 2007 |
| Sardesk Ltd | Information & communication | 2026 |
| Sargeant-Broughton Developments Ltd | Real estate | 2026 |
| SARMAD711 Ltd | Wholesale & retail | 2025 |
| Sarosh Limited | Health & social care | 2013 |
| Sarrinah Ltd | Administrative & support | 2019 |
| Sars Ltd. | Professional & scientific | 1981 |
| SAS Fusion Limited | Hospitality | 2019 |
| SAS Interiors Ltd | Construction | 2023 |
| SAS11 Logistics Ltd | Transport & logistics | 2026 |
| Sashandra Care Ltd | Health & social care | 2021 |
| Sasoka Ltd | Construction | 2025 |
| Saturn CSK Ltd | Hospitality | 2024 |
| Saturn Sales Ltd | Administrative & support | 2012 |
| Sauben Ltd. | Professional & scientific | 2020 |
| Saul Slater Window Cleaning Ltd | Administrative & support | 2023 |
| Sava Commercial Ltd | Wholesale & retail | 2023 |
| Savage Cleaning Services Limited | Administrative & support | 2022 |
| Savasaachi Marketing Agency Ltd | Professional & scientific | 2021 |
| Save My Company Limited | Administrative & support | 2025 |
| Savergy Ltd | Professional & scientific | 2025 |
| Savi Indian Trading Ltd | Hospitality | 2025 |
| Saving Zone Oldham Ltd | Wholesale & retail | 2025 |
| Savvy Productions Limited | Information & communication | 2009 |
| Saw-Tech (North West) Limited | Manufacturing | 2011 |
| Sawa Builders Ltd | Construction | 2020 |
| Sawera Talal Studio Ltd | Wholesale & retail | 2026 |
| Sawrey House Ltd | Real estate | 2021 |
| Saxon House (Ipswich) Management Company Limited | Households | 2020 |
| SAY Lifestyle Limited | Administrative & support | 2021 |
| SAZ MB Ltd | Wholesale & retail | 2025 |
| Saz's Hot and Cold Sarnies Ltd | Hospitality | 2015 |
| SB Coaching & Mentoring Ltd | Other services | 2018 |
| SB Medical Care Limited | Health & social care | 2024 |
| SB Travel(Oldham) Limited | Transport & logistics | 2016 |
| Sbaa Services Limited | Transport & logistics | 2022 |
| Sbaa Transport Ltd | Transport & logistics | 2024 |
| SBB Brows Ltd | Other services | 2023 |
| SBJ Property Holdings Limited | Real estate | 2021 |
| Sbka UK Ltd | Wholesale & retail | 2026 |
| SBN Builders and Developers Limited | Construction | 2023 |
| SBS Plumbing & Heating Limited | Construction | 2007 |
| SBT Successors Limited | Hospitality | 2004 |
| SBW Group Holdings Ltd | Hospitality | 2026 |
| SC Europe Group Ltd. | Financial services | 2022 |
| SC Maintenance Ltd | Construction | 2026 |
| Scaffolding RUS Ltd | Construction | 2026 |
| Scanda Lifts Limited | Construction | 2010 |
| Scenic Leisure Limited | Hospitality | 2018 |
| SCG Properties Limited | Real estate | 2019 |
| Schema and Spark Ltd | Professional & scientific | 2025 |
| Schofield & Sons Consulting Limited | Professional & scientific | 2025 |
| Schola Ltd | Professional & scientific | 2025 |
| Scholared UK Ltd | Education | 2023 |
| Schoolhouse (Owen Fold) Management Limited | Real estate | 2012 |
| Scie Services Ltd | Manufacturing | 2012 |
| Scientific Glass Blowing Co. Limited | Manufacturing | 1977 |
| Scientific Sanitation Solutions Ltd | Administrative & support | 2023 |
| Scilogix DEV Biotech Limited | Professional & scientific | 2024 |
| Scjnb Limited | Real estate | 2015 |
| Scnp Investment Ltd | Financial services | 2025 |
| Scoff Catering Limited | Hospitality | 2011 |
| Scoplex Ltd | Wholesale & retail | 2024 |
| Scorpio Hotel Management Limited | Hospitality | 1993 |
| Scorpio Hydraulics Limited | Professional & scientific | 2002 |
| Scotfield Limited | Manufacturing | 2020 |