| Saddleworth Lifts Limited | Manufacturing | 2016 |
| Saddleworth Marina Ltd | Wholesale & retail | 2024 |
| Saddleworth Milk Limited | Manufacturing | 2020 |
| Saddleworth Motor Services Limited | Wholesale & retail | 2009 |
| Saddleworth Physiotherapy Clinic Limited | Health & social care | 2007 |
| Saddleworth Plan and Design Group Ltd | Construction | 2015 |
| Saddleworth Plant Hire Limited | Administrative & support | 2014 |
| Saddleworth Poultry Ltd | Agriculture & fishing | 2024 |
| Saddleworth Practice Property (Oldham) LLP | | 2013 |
| Saddleworth Prestige Homes Ltd | Construction | 2019 |
| Saddleworth Property Investments Ltd | Construction | 2020 |
| Saddleworth PUB Co Ltd | Hospitality | 2019 |
| Saddleworth Restoration Conservation Ltd | Other services | 2016 |
| Saddleworth Roofing & Building Ltd | Professional & scientific | 2018 |
| Saddleworth Sash Windows Ltd | Construction | 2022 |
| Saddleworth School of Dance CIC | Arts & recreation | 2021 |
| Saddleworth Sculpt Studios Ltd | Other services | 2025 |
| Saddleworth Self Storage Ltd | Real estate | 2019 |
| Saddleworth Solar Ltd | Energy | 2025 |
| Saddleworth Spirit Merchants Ltd | Manufacturing | 2020 |
| Saddleworth Spraying Ltd | Construction | 2021 |
| Saddleworth Timber Door Company Ltd | Construction | 2016 |
| Saddleworth Traditional Sash Windows Ltd | Construction | 2016 |
| Saddleworthholdings Limited | Real estate | 2024 |
| Sadis Traders Limited | Wholesale & retail | 2021 |
| Saeon Beauty Ltd | Wholesale & retail | 2025 |
| SAF Accountancy Services Limited | Extraterritorial | 2021 |
| Safa AFG Ltd | Wholesale & retail | 2022 |
| Safana Capital Limited | Financial services | 2026 |
| Safe Car Global Ltd. | Information & communication | 2026 |
| Safe Children's Care Limited | Health & social care | 2024 |
| Safe Deposit Centre (Oldham) Limited | Transport & logistics | 2017 |
| Safe Heating Services Limited | Construction | 2014 |
| Safe Step Supplies Limited | Wholesale & retail | 2014 |
| Safe Trade MCR Ltd | Wholesale & retail | 2026 |
| Safe Wind Service Ltd | Construction | 2019 |
| Safeguard Roofing Ltd | Construction | 2025 |
| Safenest Housing CIC | Hospitality | 2024 |
| Safeplace Security Limited | Construction | 2001 |
| Safer Homes Oldham Ltd | Health & social care | 2023 |
| Safety First Care and Compliance Ltd | Health & social care | 2026 |
| Saffron Holywell Ltd | Hospitality | 2025 |
| Safia's Wish CIC | Education | 2026 |
| Saftey Critical Labour Limited | Construction | 2016 |
| Safzay Ltd | Other services | 2025 |
| Sagittarius Limited | Wholesale & retail | 1990 |
| Sagor Stockport Ltd | Hospitality | 2024 |
| Saha Meat Services Ltd | Manufacturing | 2023 |
| Sahi Properties MC Limited | Real estate | 2023 |
| Sahil Royton Limited | Hospitality | 2026 |
| Sahm Properties MCR Limited | Real estate | 2021 |
| SAI Cars Ltd | Wholesale & retail | 2023 |
| SAI Krupa SK UK Ltd | Hospitality | 2023 |
| Said Solutions Ltd | Other services | 2015 |
| Sainaz Ltd | Hospitality | 2024 |
| Sainoh Ltd | Wholesale & retail | 2023 |
| Saint Anne's Longsight(Royton)Building Company Limited | Education | 1910 |
| Saint Property Solutions Ltd | Real estate | 2025 |
| Saint. Education Limited | Administrative & support | 2024 |
| Saiqa Mehrban Welfare Limited | Real estate | 2026 |
| SAJ Building and Construction Limited | Construction | 2023 |
| Sajawal & Co Ltd | Wholesale & retail | 2020 |
| Sajid ALI Ltd | Wholesale & retail | 2026 |
| Sajid Travels Limited | Transport & logistics | 2026 |
| Sajju Traders Ltd | Wholesale & retail | 2026 |
| Sakhi Cash and Carry Ltd | Wholesale & retail | 2024 |
| Sakhi Law Chambers Ltd | Other services | 2018 |
| Sakhi Properties Ltd | Real estate | 2020 |
| Salaam Toothartist Ltd | Health & social care | 2024 |
| Salam Finance Limited | Administrative & support | 2016 |
| Salar Capital Ltd | Professional & scientific | 2016 |
| Saleem Skin Ltd | Health & social care | 2025 |
| Saleha Trading Limited | Wholesale & retail | 2019 |
| Salem Brew Ltd | Hospitality | 2019 |
| Salford City Wrestling Ltd | Arts & recreation | 2024 |
| Salientpoint Limited | Construction | 1998 |
| Salmon Fields Business Village (Oldham) Limited | Real estate | 2004 |
| Salora Grill Delight (Oldham) Ltd | Hospitality | 2019 |
| Salt Uppermill Limited | Hospitality | 2018 |
| Salty's Garage Limited | Wholesale & retail | 2017 |
| Salvador Crispy Ltd | Hospitality | 2024 |
| Salvage Solutions Ltd | Wholesale & retail | 2025 |
| Salvation Hair Limited | Other services | 2022 |
| SAM 360 Limited | Wholesale & retail | 2025 |
| SAM Car Rental Holdings Ltd | Administrative & support | 2025 |
| SAM Car Rental Ltd | Administrative & support | 2023 |
| SAM Flood Property Development Limited | Real estate | 2020 |
| SAM Motorz Ltd | Wholesale & retail | 2025 |
| SAM Travels Limited | Transport & logistics | 2018 |
| SAM UK Properties Ltd | Real estate | 2025 |
| Samco Spice Ltd | Hospitality | 2018 |
| Sameday Support Solutions Limited | Administrative & support | 2016 |
| Samfores Ltd | Information & communication | 2025 |
| Sami Consulting Enterprises Ltd | Wholesale & retail | 2025 |
| Sami Mercantile Ltd | Wholesale & retail | 2025 |
| Samjot Limited | Health & social care | 2022 |
| Samruddhi Property Holdings Ltd | Real estate | 2025 |
| Sams Appliances Ltd | Wholesale & retail | 2015 |
| Sams Helping Hands Ltd | Health & social care | 2020 |
| Samson Properties (NW) Ltd | Real estate | 2025 |