| S S Olarewaju & Co Accountants Ltd | Professional & scientific | 2026 |
| S Solutions Limited | Wholesale & retail | 2014 |
| S T E Roofing Ltd | Construction | 2024 |
| S T S Builder Ltd | Construction | 2025 |
| S V Doyle Building Ltd | Construction | 2024 |
| S Wilson Joinery Ltd | Construction | 2020 |
| S&4 Blue Limited | Wholesale & retail | 2025 |
| S&A Desserts Limited | Hospitality | 2026 |
| S&C Property Holdings Ltd | Real estate | 2025 |
| S&D Trucking Ltd | Transport & logistics | 2023 |
| S&F Automotive Ltd | Wholesale & retail | 2025 |
| S&H Brews Ltd | Wholesale & retail | 2025 |
| S&H Commercial Vehicle Repairs Ltd | Wholesale & retail | 2020 |
| S&H Fleet Maintenance Ltd | Wholesale & retail | 2026 |
| S&H Franchise Group Ltd | Hospitality | 2023 |
| S&K Bargains Ltd | Wholesale & retail | 2018 |
| S&K Enterprise Limited | Wholesale & retail | 2017 |
| S&N Properties (NW) Ltd | Real estate | 2025 |
| S&R Travelways Ltd | Hospitality | 2025 |
| S&S Bell Limited | Wholesale & retail | 2016 |
| S&S Grocery and Halal Meat Supperstore Limited | Wholesale & retail | 2025 |
| S&T Paving and Ground Works Ltd | Construction | 2025 |
| S. Breen Rigging Services Ltd | Construction | 2015 |
| S. Marsden (Builders) Limited | Construction | 2006 |
| S.A Letting Properties Ltd | Real estate | 2023 |
| S.Core (MCR) Ltd | Wholesale & retail | 2025 |
| S.D.D Decorator Limited | Construction | 2019 |
| S.Gul Pharma Ltd | Health & social care | 2024 |
| S.J. Norbury Electrical Services Ltd | Construction | 2002 |
| S.J. Taverns Company Ltd. | Hospitality | 2018 |
| S.K. Motors (Oldham) Limited | Wholesale & retail | 2004 |
| S.K. Services (NW) Ltd | Health & social care | 2021 |
| S.M.A. (Industrial Services) Limited | Manufacturing | 1984 |
| S.M.Frith Courier Deliveries UK Ltd | Transport & logistics | 2025 |
| S.M.Frith Transport Services UK 0608 Limited | Transport & logistics | 2025 |
| S.N Installation Ltd | Manufacturing | 2016 |
| S.P.L. Foods Limited | Manufacturing | 1991 |
| S.Poole Consulting Ltd | Professional & scientific | 2019 |
| S.V.T Logistics Ltd | Transport & logistics | 2019 |
| S.Vali Ltd | Wholesale & retail | 2018 |
| S.W. Pallets Limited | Manufacturing | 2019 |
| S1 Tracks Ltd | Administrative & support | 2026 |
| S2F Dreams Ltd | Real estate | 2023 |
| S8 Property Group Ltd | Real estate | 2021 |
| SA & FA Travel Ltd | Transport & logistics | 2025 |
| SA Helens Limited | Hospitality | 2020 |
| SA Legal Costs Ltd | Professional & scientific | 2025 |
| SA Oldham Limited | Hospitality | 2025 |
| SA Practitioner Ltd | Professional & scientific | 2024 |
| SA Skinology Ltd | Other services | 2021 |
| SA Spar Store Ltd | Wholesale & retail | 2023 |
| SA Vehicle Group Ltd | Wholesale & retail | 2023 |
| SAAB2187 Ltd | Transport & logistics | 2025 |
| Saasage Limited | Information & communication | 2011 |
| Saaw (Holdings) Limited | Financial services | 2022 |
| Sabah ALI Ltd | Health & social care | 2019 |
| Sabco Ltd | Wholesale & retail | 2020 |
| Sabcomuk Limited | Manufacturing | 2026 |
| Sabeer Ltd | Wholesale & retail | 2025 |
| Sabi Sand Limited | Information & communication | 2024 |
| Sabico Ltd | Hospitality | 2015 |
| Sable Silk Limited | Manufacturing | 2025 |
| Saboor Sadiq Ltd | Wholesale & retail | 2024 |
| Sabor Fusion Food Limited | Hospitality | 2026 |
| Sabre Materials Limited | Wholesale & retail | 2018 |
| Sabre Tyres Limited | Wholesale & retail | 2025 |
| Sabreen Sadiq Limited | Health & social care | 2024 |
| Sabri Plus Ltd | Administrative & support | 2012 |
| Sabri Stores Ltd | Wholesale & retail | 2012 |
| SAC Electrical Ltd | Construction | 2014 |
| SAC Group Holdings Limited | Real estate | 2020 |
| Sachdeva Medical Solutions Limited | Health & social care | 2014 |
| Sachets Limited | Manufacturing | 1987 |
| Sacred Art by Joanne Ltd | Arts & recreation | 2025 |
| Sadaf Convenience Limited | Wholesale & retail | 2025 |
| Saddlegate (Rural Sports) Limited | Real estate | 1975 |
| Saddlegrove Property Ltd | Real estate | 2025 |
| Saddleworth Accountancy Limited | Professional & scientific | 2012 |
| Saddleworth Brickwork Ltd | Construction | 2017 |
| Saddleworth Business Solutions Limited | Administrative & support | 2016 |
| Saddleworth Catering Ltd | Hospitality | 2026 |
| Saddleworth CBT Limited | Health & social care | 2024 |
| Saddleworth Ceilings & Partitions Ltd | Construction | 2022 |
| Saddleworth Community Projects CIC | Health & social care | 2019 |
| Saddleworth Consulting Services Limited | Information & communication | 2020 |
| Saddleworth Cookery School Ltd | Education | 2015 |
| Saddleworth Dog Groomers Ltd | Other services | 2022 |
| Saddleworth Ebikes Ltd | Wholesale & retail | 2020 |
| Saddleworth Enterprises Limited | Real estate | 2025 |
| Saddleworth Environmental Education Community Interest Company | Education | 2015 |
| Saddleworth GAS & Plumbing Limited | Construction | 2020 |
| Saddleworth Home Care Ltd | Health & social care | 2009 |
| Saddleworth House Management Company (2006) Limited | Real estate | 2006 |
| Saddleworth Independent Mortgages Limited | Financial services | 2002 |
| Saddleworth Interiors Ltd | Manufacturing | 2018 |
| Saddleworth Investments Company Ltd | Professional & scientific | 2021 |
| Saddleworth Joinery Services Ltd | Construction | 2022 |
| Saddleworth Kitchens Ltd | Wholesale & retail | 2022 |
| Saddleworth Landscapes Ltd | Administrative & support | 2019 |
| Saddleworth Language School Ltd | Education | 2023 |