| Sidhu Construction London Limited | Construction | 2022 |
| Sigma Shopfronts and Shutter Limited | Manufacturing | 2025 |
| Signal Advisory Group Ltd | Professional & scientific | 2025 |
| Signature Visas Limited | Professional & scientific | 2024 |
| Sigrano Club Ltd | Wholesale & retail | 2024 |
| Sikh Heritage Shri Guru Granth Sahib JI Ltd | Education | 2017 |
| Sikham Pharma Ltd | Wholesale & retail | 2022 |
| Sikhem Ltd | Construction | 2014 |
| Sikhs for Justice | Other services | 2021 |
| Silent Events Active Contribution Limited | Education | 2025 |
| Silent Hustle Ltd | Wholesale & retail | 2024 |
| Silverfoxlogistics Limited | Wholesale & retail | 2025 |
| Silvergate Property Development Ltd | Real estate | 2026 |
| Silverline Management Services Limited | Real estate | 2016 |
| Sim&Lak Ltd | Construction | 2025 |
| Simac Limited | Manufacturing | 1995 |
| Simax Electrical Ltd | Construction | 2019 |
| Simkins D Limited | Wholesale & retail | 2025 |
| Simple Invest Property Ltd | Households | 2025 |
| Simplistow Ltd | Manufacturing | 2024 |
| Simply Eating Limited | Hospitality | 2024 |
| Simply Enhanced Academy Ltd | Education | 2023 |
| Simply Enhanced Supplier Limited | Education | 2023 |
| Simply Hair & Flowers Limited | Wholesale & retail | 2011 |
| Simply Heating (UK) Ltd | Wholesale & retail | 2006 |
| Simpson Traders Ltd | Wholesale & retail | 2016 |
| Simran Mechanics Ltd | Wholesale & retail | 2026 |
| Singh and Friends Ltd | Hospitality | 2016 |
| Singh and SON Builders Ltd | Construction | 2025 |
| Singh Cyber Hygiene Ltd | Information & communication | 2026 |
| Singh Kaur Property Management Ltd | Construction | 2022 |
| Singh's Indian Kitchen Ltd | Hospitality | 2025 |
| Singhmade.Uk Limited | Construction | 2025 |
| Singhs Way Limited | Real estate | 2024 |
| Singlebedforsale.Co.Uk Limited | Wholesale & retail | 2012 |
| Sirpod IT Ltd | Information & communication | 2018 |
| Siwa Enterprises Limited | Wholesale & retail | 2021 |
| SJ Trader Private Limited | Wholesale & retail | 2020 |
| SJL Advisory Limited | Professional & scientific | 2019 |
| SK Hvac Limited | Wholesale & retail | 2024 |
| SK Property Living Ltd | Real estate | 2025 |
| SK Spices Ltd | Wholesale & retail | 2026 |
| SK2 Construction Ltd | Construction | 2026 |
| SK90 Limited | Manufacturing | 2025 |
| SKA Business Services Limited | Professional & scientific | 2015 |
| SKD Services UK Ltd | Construction | 2025 |
| Skill Ways Training & Recruitment Ltd | Administrative & support | 2017 |
| Skin of Colour Aesthetics Training Academy Ltd | Education | 2022 |
| Skinergy Aesthetics & Well-Being Ltd | Other services | 2025 |
| Skinpop Ltd | Wholesale & retail | 2025 |
| Skinroom Ltd | Health & social care | 2018 |
| SKJ Locum Limited | Professional & scientific | 2024 |
| Skylink Consultancy Ltd | Information & communication | 2022 |
| SL Investments Ltd | Construction | 2018 |
| Slater M Limited | Wholesale & retail | 2019 |
| Sleepy Otaku Senpai Ltd | Wholesale & retail | 2025 |
| SLK Enterprise Ltd | Administrative & support | 2018 |
| Slomkafacades Ltd | Construction | 2015 |
| Sm&T Ltd | Construction | 2024 |
| Small Gold Properties Ltd | Households | 2019 |
| Smallville Trans Ltd | Transport & logistics | 2017 |
| Smart Car Solutions Limited | Wholesale & retail | 2019 |
| Smart Eyecare Ltd | Wholesale & retail | 2019 |
| Smart Home Genius Limited | Professional & scientific | 2017 |
| Smart Propertyhub Limited | Real estate | 2024 |
| Smart Toilet Solutions Ltd | Wholesale & retail | 2020 |
| Smartech Accessories Limited | Wholesale & retail | 2018 |
| SMB Property Maintenance Ltd | Administrative & support | 2026 |
| SMC Furniture Repairs Ltd | Wholesale & retail | 2026 |
| SMD Reckoners Ltd | Professional & scientific | 2026 |
| Smethwick Soul Collective CIC | Education | 2025 |
| SMG Construction Limited | Construction | 2025 |
| Smith C Limited | Wholesale & retail | 2018 |
| Smith Joshua Limited | Wholesale & retail | 2022 |
| Smith R Limited | Wholesale & retail | 2023 |
| SMJ Assets Ltd | Administrative & support | 2023 |
| SMS Pharma Limited | Wholesale & retail | 2022 |
| SMS Vision Ltd | Wholesale & retail | 2019 |
| Smvkt Ltd | Wholesale & retail | 2024 |
| SMW Sign & Print Limited | Manufacturing | 2023 |
| SN Eurofixer Limited | Other services | 2015 |
| SN Property Developments U.K Ltd | Real estate | 2024 |
| Snicks Properties Ltd | Real estate | 2025 |
| SNN Signature Stays Ltd | Hospitality | 2025 |
| Soccer Circus Limited | Arts & recreation | 1991 |
| Social Jazz Ltd | Professional & scientific | 2021 |
| Softgraze Ltd | Professional & scientific | 2021 |
| Sokka Limited | Arts & recreation | 2007 |
| Sokol Ltd | Wholesale & retail | 2019 |
| Solid Applications Limited | Information & communication | 1998 |
| Solitaire Contractors Limited | Construction | 2024 |
| Solution Focused Tuitions Ltd | Information & communication | 2022 |
| SOLUTION2CARE Services Limited | Health & social care | 2017 |
| Solutions Launderette & Nail Bar Ltd | Other services | 2025 |
| Somal Healthcare Ltd | Health & social care | 2025 |
| Somal Products Ltd | Wholesale & retail | 2025 |
| Somal Transport Ltd | Transport & logistics | 2023 |
| Sommerfeld Flexboard Limited | Extraterritorial | 2017 |
| Somo Motors Ltd | Wholesale & retail | 2025 |
| Sond Builders Ltd | Construction | 2020 |