| Soomble Properties Ltd | Real estate | 2024 |
| Sophandre Care Ltd | Other services | 2015 |
| Sophandre Transport Ltd | Transport & logistics | 2023 |
| SOS Windscreen Ltd | Wholesale & retail | 2023 |
| Soul Revival Ltd | Arts & recreation | 2022 |
| Soulkani Ltd | Wholesale & retail | 2021 |
| Sourcing Squad Ltd | Wholesale & retail | 2026 |
| South Asia Travel Ltd | Administrative & support | 2025 |
| South West CBT Limited | Health & social care | 2013 |
| SP Locksmith & Security Solutions Ltd | Administrative & support | 2025 |
| SP Singh Builders Ltd | Construction | 2021 |
| Spadata Limited | Professional & scientific | 2024 |
| Spark Interior Accessories Ltd | Construction | 2023 |
| Spark Interior Hardware Ltd | Construction | 2025 |
| Spectrum OH Limited | Health & social care | 2014 |
| Speedee Ltd | Transport & logistics | 2019 |
| Speedhaul Ltd | Transport & logistics | 2025 |
| Speedy Shopfronts Ltd | Other services | 2020 |
| Speedyrepairhub Ltd | Wholesale & retail | 2026 |
| SPEEDYTRANS27 Ltd | Transport & logistics | 2025 |
| Sperin Interiors & Refurbishments Ltd | Construction | 2018 |
| SPH Farms Limited | Agriculture & fishing | 2023 |
| SPH Industrial Services Limited | Water & waste | 2025 |
| SPH Plant Ltd | Administrative & support | 2014 |
| SPH Rail Limited | Extraterritorial | 2023 |
| SPH Trade Shop Limited | Extraterritorial | 2023 |
| Spice Box Community Meals CIC | Other services | 2026 |
| Spice Box Fusion Limited | Hospitality | 2026 |
| Spice Box Sandwell Limited | Hospitality | 2024 |
| Spice Fusion Sandwell Ltd | Hospitality | 2022 |
| Spice Hawk Steel Sections Limited | Manufacturing | 1983 |
| Spice Unlocked Ltd | Administrative & support | 2020 |
| Spicer S D Limited | Wholesale & retail | 2018 |
| Spirit of SHE Ltd | Administrative & support | 2023 |
| Spitfire Logistics Ltd | Transport & logistics | 2024 |
| Spitfire MK II Limited | Financial services | 2024 |
| SPJ Traders Limited | Real estate | 2025 |
| SPN Auto Services Limited | Wholesale & retail | 2020 |
| Sport 360 Agency Limited | Professional & scientific | 2023 |
| Sprinter Pro Limited | Wholesale & retail | 2024 |
| SR Capital Homes Ltd | Real estate | 2025 |
| SRG Europe Limited | Administrative & support | 2010 |
| SS Building Ltd | Construction | 2023 |
| SS Financial Contractor Services Limited | Financial services | 2019 |
| SS Property Expert Ltd | Construction | 2026 |
| SS2 Logistics Limited | Transport & logistics | 2021 |
| SSA Transport Ltd | Wholesale & retail | 2017 |
| SSB Deep Construction Limited | Construction | 2013 |
| SSB Kitchens Limited | Wholesale & retail | 2024 |
| SSH Care Ltd | Health & social care | 2020 |
| Sskk Properties Limited | Real estate | 2025 |
| SSP Real Estate & Investments Ltd | Real estate | 2025 |
| Ssrp Property Group Ltd | Real estate | 2021 |
| Ssyuwdelt Ltd | Manufacturing | 2026 |
| ST Margaret's Holiday Park Limited | Hospitality | 2006 |
| ST. James Point Ltd | Real estate | 2025 |
| Stackryx Ltd | Information & communication | 2026 |
| Stanakzai Enterprises Ltd | Wholesale & retail | 2016 |
| Stanley Fish and Chip Shop Limited | Hospitality | 2024 |
| Star EGR Logistics Ltd | Transport & logistics | 2024 |
| STAR13 Stores Limited | Wholesale & retail | 2026 |
| Starz Academy Football Club Ltd | Education | 2022 |
| Stay Crafter Ltd | Hospitality | 2023 |
| Stayeduk Ltd | Hospitality | 2026 |
| Steadfast Haulage Europe Ltd | Transport & logistics | 2019 |
| Steen C Limited | Wholesale & retail | 2017 |
| Stephens Gaskets Limited | Manufacturing | 1947 |
| Stephens Industrial Estates Limited | Real estate | 2020 |
| Stephens Mark Limited | Wholesale & retail | 2013 |
| Stephens Plastic Mouldings Limited | Manufacturing | 2011 |
| Steve Dawson Design Ltd | Professional & scientific | 2025 |
| STG Tyre Services Ltd | Wholesale & retail | 2024 |
| STL Haulage Ltd | Transport & logistics | 2026 |
| Stone Sense Limited | Manufacturing | 2021 |
| Stone Street Tyres Ltd | Wholesale & retail | 2025 |
| Stoneage Property Holdings Limited | Wholesale & retail | 2025 |
| Stonecrop Finance Limited | Administrative & support | 2025 |
| Stoneshare Limited | Professional & scientific | 1993 |
| Storagely Limited | Real estate | 1998 |
| Straight There Ltd | Transport & logistics | 2018 |
| Strategic Accountants Ltd | Professional & scientific | 2023 |
| Stratford Bentley Ltd | Health & social care | 2014 |
| Strength Services Limited | Transport & logistics | 2025 |
| STS Medics Ltd | Education | 2018 |
| STS Traders Ltd | Construction | 2025 |
| Student Spot Ltd | Construction | 2023 |
| Studio Dawson Ltd | Professional & scientific | 2026 |
| Studyboard UK Ltd | Administrative & support | 2023 |
| SUB Contractors Accountancy Services Limited | Professional & scientific | 1993 |
| Subam Ltd | Wholesale & retail | 2022 |
| Success Mastery Ltd | Professional & scientific | 2022 |
| Sufarooq Ltd | Wholesale & retail | 2025 |
| Suits U FTS Limited | Wholesale & retail | 2021 |
| Sujinder Gill Ltd | Construction | 2014 |
| Sukhi Transport Ltd | Transport & logistics | 2025 |
| Sukhraj Cargo Ltd | Transport & logistics | 2020 |
| Sultana Walsall Ltd | Hospitality | 2020 |
| Sultania Courier Limited | Transport & logistics | 2015 |
| Suly Ltd | Health & social care | 2014 |
| Summit Pro Drive Ltd | Education | 2025 |