| Sandwell Housings Ltd | Real estate | 2024 |
| Sandwell Irish Community Association Limited | Health & social care | 2013 |
| Sandwell Properties Ltd | Construction | 2022 |
| Sandwell Wellbeing Limited | Health & social care | 2018 |
| Sandy Bhutta Ltd | Real estate | 2024 |
| Sangha Development and Construction Ltd | Construction | 2026 |
| Sangha Motors Ltd | Wholesale & retail | 2023 |
| Sangha Properties (Midlands) Limited | Real estate | 2020 |
| Sanghera Farms Limited | Wholesale & retail | 2023 |
| Sanlove Limited | Health & social care | 2015 |
| Sanrik Ltd | Wholesale & retail | 2023 |
| Sant Baba Bhagwan Singh Ltd | Transport & logistics | 2021 |
| Saplm Limited | Information & communication | 2014 |
| Sapphire Air Ltd | Construction | 2006 |
| Sapphire Medical Ltd | Other services | 2022 |
| Sarai Subs Ltd | Hospitality | 2019 |
| Saran S Arora Limited | Wholesale & retail | 2021 |
| Sarap Store Ltd | Wholesale & retail | 2023 |
| Sargon Building Services Ltd | Construction | 2023 |
| Saroy Double Glazing Ltd | Construction | 2022 |
| Sascom Products Ltd. | Wholesale & retail | 2000 |
| Satpal Transport Ltd | Transport & logistics | 2018 |
| Sauce Labs Software UK Limited | Administrative & support | 2019 |
| Savanna Heights Ltd | Health & social care | 2024 |
| Save Eco Ltd | Construction | 2024 |
| Savey Limited | Wholesale & retail | 2023 |
| SAW & Order Ltd | Construction | 2025 |
| Sawans Fitness Gear Ltd | Manufacturing | 2018 |
| Saxon Watches Limited | Manufacturing | 2026 |
| SB Electrical & Construction Ltd | Manufacturing | 2014 |
| SB Transport Service Ltd | Construction | 2025 |
| SBB Haulage Limited | Transport & logistics | 2017 |
| Sbecomservices Ltd | Wholesale & retail | 2025 |
| Sbetd Holdings Ltd | Financial services | 2024 |
| SBP Audiology Ltd | Health & social care | 2021 |
| SBS Engineering Solutions Limited | Construction | 2026 |
| SBS Heating & Plumbing Solutions Ltd | Construction | 2021 |
| Scafom-Rux United Kingdom Limited | Manufacturing | 2004 |
| Scarrilong Limited | Real estate | 1977 |
| Scct Services Ltd | Health & social care | 2017 |
| School Image Signage Ltd | Professional & scientific | 2014 |
| Scruffypet Products Ltd | Wholesale & retail | 2015 |
| SDN Group Limited | Financial services | 2026 |
| SDN Management Limited | Real estate | 2021 |
| SDN Transport Limited | Transport & logistics | 2025 |
| Sdsl Properties Limited | Financial services | 2017 |
| Sea Fryer Ltd | Hospitality | 2026 |
| Seabreeze Enterprises Limited | Financial services | 1999 |
| Seba Best Solution Ltd | Transport & logistics | 2016 |
| Sebucci Interiors Ltd | Extraterritorial | 2023 |
| Second Chance Living CIC | Hospitality | 2025 |
| Section 5 Limited | Financial services | 2010 |
| Seehra Transport Limited | Transport & logistics | 2015 |
| Seerat and Saihaj Ltd | Real estate | 2025 |
| Sehmi Developments Ltd | Construction | 2017 |
| Sekscare Healthcare Limited | Health & social care | 2023 |
| Selbar LP | | 2009 |
| Select Contract Services Limited | Administrative & support | 2020 |
| Selvek Ltd | Transport & logistics | 2016 |
| Selwood Pump Holding Limited | Manufacturing | 1967 |
| Sendor Car Parts Ltd | Wholesale & retail | 2017 |
| Sensoryspaceuk Ltd | Health & social care | 2020 |
| Sentis Consulting Ltd | Professional & scientific | 2026 |
| Sereene Investments Ltd | Real estate | 2019 |
| Serene Space Properties Ltd | Financial services | 2025 |
| Sereneity Counselling & Coaching Services Ltd | Education | 2020 |
| Sereneity Scents Ltd | Other services | 2020 |
| Serenity Construction Services Ltd | Construction | 2025 |
| Setcad Building Limited | Construction | 2026 |
| Seward G Limited | Wholesale & retail | 2020 |
| Seyore Ltd | Health & social care | 2024 |
| SF Engineering Ltd | Manufacturing | 2023 |
| Sg(Gold) Properties Ltd | Real estate | 2024 |
| Sgpc Coordination Centre Community Interest Company | Education | 2025 |
| SH Cars Midlands Ltd | Wholesale & retail | 2023 |
| SH Judge Transport Ltd | Transport & logistics | 2025 |
| Shabir Khan Ltd | Wholesale & retail | 2025 |
| Shades of Emerald Eco Limited | Manufacturing | 2026 |
| Shahi Kulfi Limited | Wholesale & retail | 2017 |
| Shalom Boutique Limited | Wholesale & retail | 2023 |
| Shanz Property Services Limited | Real estate | 2024 |
| Sharma Sweet Centre Ltd | Wholesale & retail | 2026 |
| Sharp SMP Ltd | Other services | 2025 |
| Shaw Trust Limited(The) | Administrative & support | 1983 |
| Shayan Pizzeria Ltd | Hospitality | 2025 |
| Sheemar Limited | Transport & logistics | 2025 |
| Sheikh Logistices Ltd | Wholesale & retail | 2026 |
| Shergill Corporation Company Ltd | Hospitality | 2024 |
| Shiftwise Limited | Transport & logistics | 2024 |
| Shipshore Services Ltd | Transport & logistics | 2022 |
| Shira Builders Ltd | Construction | 2022 |
| Shoaiboptical Ltd | Health & social care | 2024 |
| Shop House Limited | Wholesale & retail | 2025 |
| Shorts on Limited | Information & communication | 2024 |
| Shread Giannini Holdings Limited | Financial services | 2024 |
| Shri Kalpagavruksha Seva Sangam Ltd | Health & social care | 2024 |
| Shunfa 68 Limited | Hospitality | 2025 |
| SHY Associates Ltd | Administrative & support | 2020 |
| SI Advisory Services Limited | Financial services | 2025 |
| Siam Oriental Limited | Health & social care | 2023 |