| Simabel Realty Limited | Real estate | 2023 |
| Simbarashe and Co Services Limited | Health & social care | 2025 |
| Simla Peppers Limited | Hospitality | 2010 |
| Simon Aucott Holdings Limited | Wholesale & retail | 2022 |
| Simoniti Builders Limited | Construction | 2007 |
| Simple Tuition Ltd | Education | 2023 |
| Simpleledger Limited | Professional & scientific | 2022 |
| Simpleserv Ltd | Information & communication | 2026 |
| Simply Bathrooms Online Limited | Extraterritorial | 2016 |
| Simply Deep Trading Limited | Wholesale & retail | 2025 |
| Simply Sourced Homes Ltd | Real estate | 2025 |
| Sinclair Projects Ltd | Professional & scientific | 2024 |
| Singh Transport Limited | Transport & logistics | 2018 |
| Singhbrothersgroup Limited | Wholesale & retail | 2025 |
| Singular Homes (Glebe Farm) Limited | Construction | 2024 |
| Singular Homes Limited | Construction | 2015 |
| Siniyon Services Ltd | Administrative & support | 2023 |
| Sirius Light Ltd | Information & communication | 2023 |
| Sista Media Ltd | Information & communication | 2026 |
| Siteplex Limited | Information & communication | 2021 |
| SIX Care Solutions Ltd | Health & social care | 2020 |
| SJ Global Textile Consulting Limited | Wholesale & retail | 2013 |
| SJ Group Holdings Ltd | Health & social care | 2021 |
| SJL Consultancy Limited | Professional & scientific | 2024 |
| SJL Engineering Limited | Professional & scientific | 2003 |
| Sjmf Management Limited | Health & social care | 2016 |
| SK Wholesale Trading Limited | Wholesale & retail | 2026 |
| SKA Facility Services Ltd | Administrative & support | 2025 |
| SKA Holdings & Investments Ltd | Financial services | 2025 |
| SKB Creations Limited | Information & communication | 2010 |
| SKD Delivery Solutions Limited | Professional & scientific | 2022 |
| Skilledin Ltd | Information & communication | 2020 |
| Skinz Tanning Ltd | Other services | 2021 |
| SKP Houses Ltd | Real estate | 2016 |
| Sky Blue Care UK Ltd | Health & social care | 2023 |
| Sky Green Marketing Ltd | Professional & scientific | 2024 |
| Skyb Company 3 Ltd | Other services | 2023 |
| Skygroup Trade Ltd | Wholesale & retail | 2025 |
| Skyline (Midlands) Limited | Construction | 2022 |
| Skyracearena Ltd | Transport & logistics | 2026 |
| Slaghuis Ltd | Wholesale & retail | 2020 |
| Slamlock Ltd | Professional & scientific | 2022 |
| Sleep&Dreams Ltd | Information & communication | 2021 |
| SLG Hadland Properties Ltd | Real estate | 2025 |
| Slick Slice Ltd | Administrative & support | 2024 |
| Slip O Grip Limited | Construction | 2023 |
| Slmn Services Ltd | Construction | 2025 |
| SLN Childcare Limited | Health & social care | 2024 |
| SLN Spedition Limited | Transport & logistics | 2017 |
| Slots Ltd | Households | 2025 |
| SM Car Wash Ltd | Administrative & support | 2025 |
| SM Hospitality Ltd | Hospitality | 2023 |
| SM Playpadel Limited | Arts & recreation | 2024 |
| Smalbergher Transport Ltd | Construction | 2017 |
| Smallfee Limited | Transport & logistics | 2015 |
| Smart Cherry Mobiles Ltd | Wholesale & retail | 2014 |
| Smart CM Ltd | Wholesale & retail | 2014 |
| Smart Future Education Ltd | Education | 2023 |
| Smart Interior Contracts Limited | Construction | 2018 |
| Smart Investors Alliance Ltd | Hospitality | 2024 |
| Smart Work Global Ltd | Construction | 2025 |
| Smarta Stays Ltd | Hospitality | 2025 |
| Smartlec Leicester Limited | Construction | 2017 |
| Smartphones and Gadgets Ltd | Other services | 2019 |
| SMC Design Solutions Limited | Professional & scientific | 2011 |
| SMC Logistics Ltd | Transport & logistics | 2025 |
| SMC Materials Limited | Manufacturing | 2022 |
| SMG Home & Roofing Limited | Construction | 2026 |
| Smmk Limited | Real estate | 2018 |
| Smmr Transport Ltd | Transport & logistics | 2020 |
| Smooth Clinic Limited | Other services | 2017 |
| Smooth Saling Ltd | Health & social care | 2025 |
| SMP Developments Ltd | Construction | 2024 |
| SMR Trans Ltd | Transport & logistics | 2011 |
| Smutt Ltd | Wholesale & retail | 2025 |
| SN Accounts Ltd | Professional & scientific | 2013 |
| SN Bookkeeping Ltd | Professional & scientific | 2013 |
| Snapsave Limited | Wholesale & retail | 2025 |
| Soag Investments Ltd | Real estate | 2015 |
| Soapy Suds Limited | Other services | 2019 |
| Social Training Activities and Recreational Sport Limited | Education | 2006 |
| SOCKET2M Limited | Construction | 2011 |
| Soft Touch Phlebotomy Ltd | Education | 2024 |
| Software T&D Limited | Professional & scientific | 2019 |
| Sohal & Kalm Property Limited | Real estate | 2023 |
| Soil Science Limited | Construction | 2020 |
| SOL Sisters & Co Limited | Other services | 2026 |
| Solar Steel Systems Ltd | Manufacturing | 2017 |
| Solid Edge Ltd | Wholesale & retail | 2025 |
| Solid Trans Ltd | Transport & logistics | 2026 |
| Solihull Theatre Company Limited | Arts & recreation | 2010 |
| Solitaire Office Supplies Limited | Wholesale & retail | 1999 |
| Solofibretec Limited | Construction | 2022 |
| Solvent Continental Logistics Ltd | Transport & logistics | 2015 |
| Somercotes Properties Limited | Professional & scientific | 2002 |
| Somma Group Ltd | Financial services | 2025 |
| Sonoma Acoustics Limited | Manufacturing | 2016 |
| Soolee Ltd | Health & social care | 2024 |
| Sopchy Ltd | Information & communication | 2020 |
| Sophiaa Limited | Hospitality | 2017 |