| Sophie Amelia Beauty Services Ltd | Other services | 2021 |
| Sophie Transport Ltd | Transport & logistics | 2016 |
| Sophisticated Stays Limited | Real estate | 2016 |
| Sorellas Finds Limited | Wholesale & retail | 2024 |
| Sormar Limited | Transport & logistics | 2019 |
| Sorsica Ltd. | Wholesale & retail | 2025 |
| Sotv Worldwide Ltd | Wholesale & retail | 2022 |
| Souchetrans Ltd | Hospitality | 2019 |
| Sound Clear Holdings Limited | Financial services | 2025 |
| Southview Residential Ltd | Real estate | 2020 |
| Sovereign Play Limited | Manufacturing | 2002 |
| Sovranos Ltd | Hospitality | 2012 |
| Space Cleaners Nuneaton Franchise Ltd | Administrative & support | 2026 |
| Space Creators Limited | Construction | 2024 |
| SPACE9 Nuneaton Limited | Arts & recreation | 2026 |
| Spark & Draft Limited | Wholesale & retail | 2026 |
| Sparkenhoe Counsel Ltd | Professional & scientific | 2026 |
| Sparkles and Reflections Cleaning Ltd | Administrative & support | 2016 |
| Specialised Woodworking (of Coventry) Limited | Manufacturing | 2013 |
| Specialist Concrete (Marine) Ltd | Professional & scientific | 2020 |
| Specialized Repair Services Ltd | Wholesale & retail | 2008 |
| Speed One Limited | Transport & logistics | 2025 |
| Speeddy Ltd | Other services | 2024 |
| Sperr-Inns Ltd. | Hospitality | 2004 |
| Sperrin Brewery Ltd | Manufacturing | 2011 |
| Speymill OOD Ltd | Construction | 1997 |
| SPG Ventures Limited | Real estate | 2024 |
| Spinney Homes Limited | Construction | 2013 |
| Spires Event Catering Ltd | Hospitality | 2020 |
| Spiridon Transport Ltd | Transport & logistics | 2022 |
| Spiru Ltd | Transport & logistics | 2026 |
| Spitnsawdust UK Ltd | Manufacturing | 2018 |
| Splinters & Sparks Ltd | Professional & scientific | 2021 |
| Spooky Competitions Ltd | Wholesale & retail | 2025 |
| Sport Streaming Services Ltd | Manufacturing | 2022 |
| Sporting Touch Limited | Wholesale & retail | 2018 |
| Spring Accountancy Services Ltd | Professional & scientific | 2017 |
| Spring Networking Ltd | Administrative & support | 2021 |
| Springbourne Contractors Limited | Construction | 2022 |
| Springbourne Developments Limited | Construction | 1996 |
| Springbourne Group (Holdings) Limited | Construction | 2016 |
| Springbourne Heritage Limited | Professional & scientific | 2022 |
| Springbourne Homes Limited | Construction | 2002 |
| Springbourne Rural and Social Limited | Construction | 2014 |
| Springbourne Stoke Golding Limited | Construction | 2022 |
| Springbourne the Coppice Limited | Construction | 2022 |
| Springfields (Ansley) Limited | Wholesale & retail | 2000 |
| Springfields Construction LLP | | 2006 |
| Springfields Enterprise Investment Ltd | Real estate | 2019 |
| Springfields Market Limited | Administrative & support | 2024 |
| Springfields Promotions Limited | Administrative & support | 2010 |
| Springhurst Management Company Ltd | Households | 2011 |
| Springpharm Care Limited | Wholesale & retail | 2014 |
| Sprint-Lite Autos Ltd | Wholesale & retail | 2018 |
| Sprzedaz DO Wielkiej Brytanii Ltd | Professional & scientific | 2021 |
| Spudz Mash N Dash Ltd | Hospitality | 2025 |
| SPV A&S Ltd | Construction | 2022 |
| SPV CDK Solaruk Ltd | Professional & scientific | 2019 |
| SPV PJ Ltd | Construction | 2021 |
| SQL Drifter Ltd | Information & communication | 2020 |
| SQUARE10 Services Limited | Administrative & support | 2022 |
| Squirrel at Wellsborough Limited | Wholesale & retail | 2018 |
| SS Taxi Services Limited | Transport & logistics | 2023 |
| Ssak Systems Ltd | Professional & scientific | 2023 |
| Ssrd Investments Ltd | Real estate | 2025 |
| Ssyls Ltd | Real estate | 2023 |
| ST Awlyn Ltd | Hospitality | 2018 |
| ST Giles Northampton Limited | Construction | 2025 |
| ST Matthews Property Limited | Real estate | 2019 |
| ST Nicolas Whala Ltd | Health & social care | 2024 |
| ST. Nicolas Park Development Limited | Real estate | 1963 |
| Staeger Packaging Solutions Ltd | Manufacturing | 2000 |
| Staff 24 Care Ltd | Health & social care | 2018 |
| Staffs Moorlands Developments Limited | Construction | 2013 |
| Stagelogic Limited | Wholesale & retail | 2011 |
| Staicu Ltd | Construction | 2021 |
| Stain Plant Limited | Construction | 2000 |
| Stainless Studio Limited | Manufacturing | 2011 |
| Stamatov Services Limited | Construction | 2017 |
| Standard Import Export Limited | Wholesale & retail | 2023 |
| Stanley's Toy Shop Ltd | Wholesale & retail | 2024 |
| Stanworth Fine Art Limited | Wholesale & retail | 2008 |
| Star Group Logistics Ltd | Transport & logistics | 2025 |
| Star Taxis Limited | Transport & logistics | 2019 |
| Star Valet Limited | Professional & scientific | 2002 |
| Stardust Memorials Ltd | Transport & logistics | 2025 |
| Start on the Road Ltd | Transport & logistics | 2022 |
| Statue Homes Ltd | Construction | 2016 |
| Stayclean Contract Cleaning Services Limited | Administrative & support | 1994 |
| Steadlets Ltd | Real estate | 2025 |
| Steadweb Ltd | Administrative & support | 2015 |
| Steele Speech and Language Therapy Limited | Health & social care | 2023 |
| Steelpro Limited | Manufacturing | 1998 |
| Stefal Trans Limited | Transport & logistics | 2013 |
| Stefcloud Ltd | Information & communication | 2025 |
| Steff House Ltd | Wholesale & retail | 2025 |
| Stelth Ltd | Hospitality | 2024 |
| Step and Grow Limited | Professional & scientific | 2020 |
| Stephanie Jones Hair MB Ltd | Other services | 2020 |
| Stepping Stone Media Limited | Information & communication | 2004 |