| Sparkle and Shine Learning Hub LLP | | 2020 |
| Sparkle Clean Cleaning Ltd | Administrative & support | 2025 |
| Sparkle Hair and Beauty Studio Ltd | Wholesale & retail | 2024 |
| Sparkle Interiors Ltd | Administrative & support | 2022 |
| Sparkles Estate Ltd | Real estate | 2025 |
| Sparkling Spaces Ltd | Administrative & support | 2025 |
| Sparkling Stays Ltd | Administrative & support | 2023 |
| Sparkright Electrical East Midlands Limited | Construction | 2012 |
| Sparks Staple Wine Ltd | Wholesale & retail | 2022 |
| Sparky & Plumb Ltd | Construction | 2015 |
| Sparky STU Ltd | Construction | 2014 |
| Sparkyz Electrical Limited | Construction | 2013 |
| Sparrow Property Ltd | Real estate | 2025 |
| Sparrow Research Limited | Professional & scientific | 2016 |
| Sparse Ltd | Wholesale & retail | 2023 |
| Spartacus Spas Limited | Wholesale & retail | 2020 |
| Spartan C P & Security Ltd | Administrative & support | 2026 |
| Spartan Surfacing Limited | Construction | 2026 |
| Spartek Electrical Ltd | Manufacturing | 2009 |
| Spartek Installations Limited | Manufacturing | 2019 |
| Spartium Limited | Information & communication | 2000 |
| Spass Limited | Information & communication | 2008 |
| SPB Transport Limited | Transport & logistics | 2021 |
| Spcr Holdings Limited | Financial services | 2025 |
| Spds Investments Ltd | Professional & scientific | 2018 |
| Speak Legal CIC | Professional & scientific | 2019 |
| Speak Media (UK) Limited | Professional & scientific | 2010 |
| Speak Productions Ltd | Extraterritorial | 2019 |
| Special Education UK Ltd | Financial services | 2023 |
| Special Needs West Sussex Ltd | Education | 2025 |
| Special Occasions East Midlands Ltd | Other services | 2024 |
| Special Projects Hereford Limited | Professional & scientific | 2008 |
| Specialised Automation Services Limited | Construction | 2017 |
| Specialised Electrical Machines Design Ltd | Professional & scientific | 2021 |
| Specialised Electrical Services Limited | Construction | 2017 |
| Specialist Earthing and Lightning Protection UK Limited | Construction | 2019 |
| Specialist Explosive Services Contracts Limited | Mining & quarrying | 2000 |
| Specialist Explosive Services Demolition Limited | Construction | 2011 |
| Specialist Explosive Services Holdings Limited | Financial services | 2017 |
| Specialist Explosive Services Limited | Mining & quarrying | 1974 |
| Specialist Fastener Systems Limited | Extraterritorial | 2023 |
| Specialist Framing Services Limited | Construction | 2021 |
| Specialist Homecare Group Ltd | Health & social care | 2023 |
| Specialist Metal Fabrications Ltd | Manufacturing | 2021 |
| Specialist Road Services Limited | Administrative & support | 2018 |
| Specialist Surgeons Alliance Ltd | Health & social care | 2019 |
| Specialist Surgeons Holdings Ltd | Financial services | 2024 |
| Specialist Van Leasing Ltd | Wholesale & retail | 2012 |
| Specialty Chilled Foods Group Limited | Wholesale & retail | 1996 |
| Specialty Foods Group Limited | Professional & scientific | 2003 |
| Specsfactory Germany Ltd. | Wholesale & retail | 2015 |
| Spectacle Designer Studio Ltd | Wholesale & retail | 2025 |
| Spectol Ltd | Professional & scientific | 2026 |
| Spectre Miniatures Limited | Wholesale & retail | 2016 |
| Spectroform Engineering Limited | Manufacturing | 2019 |
| Spectrum Aggregates Limited | Construction | 2009 |
| Spectrum Brands Emea UK Limited | Manufacturing | 1960 |
| Spectrum Decorating Services Ltd | Construction | 2016 |
| Spectrum Design Studio Ltd | Professional & scientific | 2014 |
| Spectrum Energy Systems Ltd | Construction | 2011 |
| Spectrum Mechanical Services Limited | Construction | 2011 |
| Spectrum Printers Ltd. | Manufacturing | 2000 |
| Spectrum Tcgs Ltd | Wholesale & retail | 2026 |
| Spectrum Wind Services Ltd | Manufacturing | 2017 |
| Spedding Homes Limited | Other services | 2023 |
| Speech Craft Ltd | Health & social care | 2026 |
| Speechright Ltd | Health & social care | 2021 |
| Speed Care Services Limited | Health & social care | 2022 |
| Speed Quantum Ltd | Transport & logistics | 2024 |
| Speedoo Club Limited | Wholesale & retail | 2019 |
| SPEEDSHOP44 Limited | Wholesale & retail | 2026 |
| Speedy Brothers Ltd | Transport & logistics | 2022 |
| Speedy Dent Repair Limited | Wholesale & retail | 2012 |
| Speedy Eats Ltd | Hospitality | 2025 |
| Speedy Lewy&Gy Ltd | Transport & logistics | 2025 |
| Speedy Spanners Autocentre Ltd. | Wholesale & retail | 2016 |
| Speedypage Ltd | Information & communication | 2021 |
| Speedys Mobile Fitting Services Ltd | Wholesale & retail | 2015 |
| Speedys Properties Limited | Real estate | 2012 |
| Speedys Wheels & Tyres (Derby) Limited | Wholesale & retail | 2010 |
| Speedys Wheels & Tyres (Leicester) Limited | Wholesale & retail | 2010 |
| Speedys Wheels & Tyres Walsall Ltd | Wholesale & retail | 2015 |
| Speedys Wheels Online Ltd | Wholesale & retail | 2014 |
| Speedys Wheels&Tyres Ltd | Wholesale & retail | 2020 |
| Speeron Consulting Ltd | Professional & scientific | 2017 |
| Spek Build Ltd | Construction | 2021 |
| Spenbeck Consulting Limited | Professional & scientific | 2023 |
| Spenbeck Holdings Ltd | Financial services | 2025 |
| Spenbeck Limited | Real estate | 1981 |
| Spence Communications Limited | Professional & scientific | 2007 |
| Spencer & Brown Tile Agency Limited | Construction | 2014 |
| Spencer Birch LLP | | 2002 |
| Spencer Construction (Homes) Limited | Construction | 2018 |
| Spencer Executive Search Limited | Administrative & support | 2001 |
| Spencer Flooring Limited | Construction | 2006 |
| Spencer Freeholds Limited | Extraterritorial | 2014 |
| Spencer Homes Nottingham Ltd | Construction | 2015 |
| Spencer Mason Developments Ltd | Real estate | 2019 |
| Spencer Properties (Nottingham) Limited | Real estate | 2008 |
| Spencer Properties (Nottingham) Two Limited | Real estate | 2023 |