| South Asian Cultural Services Ltd | Education | 2023 |
| South Cavendish Property Co. Limited | Real estate | 1979 |
| South Consultancy Services Ltd | Administrative & support | 2025 |
| South Cottage Limited | Health & social care | 2012 |
| South East Fertility Clinic Ltd | Health & social care | 2008 |
| South Nottingham Electrical Ltd | Construction | 2021 |
| South Nottingham Scaffold Ltd | Construction | 2025 |
| South Notts Fabrications Ltd | Manufacturing | 2012 |
| South Notts Handyman Ltd | Construction | 2026 |
| South Notts Hunt Limited | Agriculture & fishing | 2008 |
| South Notts Painting Ltd | Construction | 2015 |
| South Notts Physiotherapy Ltd | Health & social care | 2018 |
| South Parade Property Co Ltd. | Real estate | 2017 |
| South River Properties Ltd | Real estate | 2024 |
| South View Properties Limited | Real estate | 2025 |
| South West Hearing Care Crewkerne Limited | Wholesale & retail | 2024 |
| South West Hearing Care Limited | Wholesale & retail | 2018 |
| South West Hearing Care Westbury Limited | Wholesale & retail | 2021 |
| South West Hearing Holdings Limited | Financial services | 2021 |
| South West Kitchens and Bathrooms Limited | Households | 2023 |
| South Yorkshire SUB Ltd | Hospitality | 2021 |
| Southbank Developments International Ltd | Construction | 2021 |
| Southbank Electrical Ltd | Construction | 2015 |
| Southern Derbyshire Lift (Midco) (NO.2) Limited | Professional & scientific | 2006 |
| Southern Derbyshire Lift (Midco) Limited | Professional & scientific | 2003 |
| Southern Derbyshire Lift Company Limited | Administrative & support | 2003 |
| Southern Derbyshire Lift Project Company (NO. 1) Limited | Administrative & support | 2003 |
| Southern Derbyshire Lift Project Company (NO.2) Limited | Real estate | 2006 |
| Southern Households Limited | Construction | 1968 |
| Southernwood Capital LLP | | 2020 |
| Southernwood Residential I Founder Partner Limited Partnership | | 2019 |
| Southernwood Residential I Limited Partnership | | 2019 |
| Southernwood Residential II Founder Partner Limited Partnership | | 2021 |
| Southernwood Residential II Limited Partnership | | 2021 |
| Southrop Ltd | Wholesale & retail | 2022 |
| Southwell Computer Centre Ltd | Information & communication | 2011 |
| Southwell Guitars Limited | Manufacturing | 2002 |
| Southwell Hair and Beauty Limited | Other services | 2023 |
| Southwell Interiors Limited | Construction | 2014 |
| Southwell Landscape & Garden Services Limited | Administrative & support | 1996 |
| Southwell Marketing Ltd | Administrative & support | 2022 |
| Southwell Physiotherapy Limited | Health & social care | 2004 |
| Southwell Poultry Services Limited | Extraterritorial | 2018 |
| Southwell Tuning Ltd | Wholesale & retail | 2021 |
| Southwest Fire Doors Ltd | Construction | 2025 |
| Southworth Developments Limited | Construction | 1998 |
| Souvlaki Treat Limited | Wholesale & retail | 2024 |
| Sovereign & Lavender Limited | Real estate | 2018 |
| Sovereign Consortium Ltd | Professional & scientific | 2025 |
| Sovia Ltd | Wholesale & retail | 2020 |
| SOW (Nottingham) Ltd | Wholesale & retail | 2013 |
| Sowter Electrical Services Limited | Construction | 2013 |
| SOY Consultancy Ltd | Professional & scientific | 2021 |
| SP 0117 Limited | Transport & logistics | 2017 |
| SP Cantonese Limited | Hospitality | 2019 |
| SP Collections Ltd | Professional & scientific | 2025 |
| SP Electrical Engineering Contractors Ltd | Construction | 2023 |
| SP North Associates Limited | Professional & scientific | 2005 |
| SP Property Advisors Limited | Financial services | 2017 |
| SP Sports Consultancy Ltd | Arts & recreation | 2025 |
| Spa Diamond Nottingham Limited | Health & social care | 2015 |
| Spa Electrical Limited | Construction | 1998 |
| Spa Publishing Ltd | Information & communication | 2007 |
| Spa Sales & Marketing Limited | Professional & scientific | 2019 |
| SPA4KICKSUK Ltd | Administrative & support | 2024 |
| Space Battles Network Ltd | Information & communication | 2023 |
| Space Data Centres Ltd | Wholesale & retail | 2014 |
| Space Data Cloud Ltd | Extraterritorial | 2023 |
| Space Dock Ltd | Transport & logistics | 2024 |
| Space Inclusive and Creative LLP | | 2010 |
| Space Inclusive Ltd | Health & social care | 2017 |
| Space Realty Ltd | Real estate | 2021 |
| Space Songs (Alvin LEE) Limited | Extraterritorial | 1974 |
| Spacehopper Properties Ltd | Real estate | 2016 |
| Spacemetric Limited | Information & communication | 2007 |
| Spaco Services Ltd | Administrative & support | 2016 |
| Spaghetti Maths Limited | Education | 2015 |
| Spalding V.E. Limited | Other services | 2008 |
| Spalls Limited | Administrative & support | 1999 |
| Spand Enterprises Limited | Information & communication | 1991 |
| Spanish Bar Limited | Hospitality | 2003 |
| Spare Deal Tyres Limited | Wholesale & retail | 2013 |
| Spark Advisory Limited | Financial services | 2024 |
| Spark Bidco Limited | Financial services | 2021 |
| Spark Business Energy Reclaims Limited | Administrative & support | 2024 |
| Spark Collective INT Limited | Professional & scientific | 2023 |
| Spark Midco 2 Limited | Extraterritorial | 2021 |
| Spark Midco Limited | Financial services | 2021 |
| Spark Pikco Limited | Financial services | 2023 |
| Spark Projects Ltd | Professional & scientific | 2025 |
| Spark Sensory Ltd | Education | 2016 |
| Spark Stem Ltd | Professional & scientific | 2023 |
| Spark Topco Limited | Financial services | 2021 |
| Spark Web Ltd | Wholesale & retail | 2025 |
| Sparked FM Ltd | Information & communication | 2026 |
| Sparkhill Electrical Limited | Construction | 1988 |
| Sparkle & Delivery Solution Ltd | Transport & logistics | 2025 |
| Sparkle & Lace Occasions Limited | Other services | 2018 |
| Sparkle Accountancy Limited | Professional & scientific | 2019 |
| Sparkle and Shine Cleaners Ltd | Administrative & support | 2014 |