| Something Ltd | Wholesale & retail | 2017 |
| Something of Freedom Limited | Professional & scientific | 2024 |
| Somewhere on Earth Productions UK Ltd | Information & communication | 2023 |
| Sommers-Gosling Ltd | Real estate | 2022 |
| Somo Electrical Ltd | Construction | 2020 |
| Somsmedia Ltd | Professional & scientific | 2024 |
| SON Enterperise Ltd | Wholesale & retail | 2025 |
| Sonatune Ltd | Information & communication | 2020 |
| Sonder Design Ltd | Professional & scientific | 2016 |
| Sonder Training Group Limited | Other services | 2024 |
| Sondhi Sports Group Limited | Information & communication | 2018 |
| Songtime CIC | Arts & recreation | 2017 |
| Sonia Waller Ltd | Wholesale & retail | 2024 |
| Sonianoire Ltd | Other services | 2025 |
| Sonic Vision Limited | Construction | 2010 |
| Sonicality Limited | Manufacturing | 2024 |
| Sonlumiere and Loxleywood Limited | Construction | 2012 |
| Sonmez Express Ltd | Wholesale & retail | 2022 |
| Sonnetchi Limited | Health & social care | 2015 |
| Sonning Vintage Watches Limited | Wholesale & retail | 2011 |
| Sonos Logistic Ltd | Transport & logistics | 2021 |
| Sontex (UK) Limited | Extraterritorial | 2013 |
| Soom Holdings Limited | Professional & scientific | 2025 |
| Soomro Ltd | Health & social care | 2019 |
| Soothe Limited | Wholesale & retail | 2013 |
| Soothing Soles Ltd | Information & communication | 2017 |
| Sooton Limited | Professional & scientific | 2019 |
| Sopgood Cleaning Ltd | Wholesale & retail | 2025 |
| Sopharmony Ltd | Wholesale & retail | 2024 |
| Sophiaslittlehugs Ltd | Wholesale & retail | 2025 |
| Sophie Brown Design Limited | Professional & scientific | 2026 |
| Sophie Macrae Mrcvs Limited | Professional & scientific | 2018 |
| Sophie Shelley Limited | Health & social care | 2025 |
| Sophie Shop Limited | Wholesale & retail | 2018 |
| Sophie's Academy of Performing Arts Limited | Arts & recreation | 2013 |
| Sophie's Nails Nottingham Ltd | Other services | 2024 |
| Sophisticated Health Chiropractic Limited | Health & social care | 2022 |
| Sophol Healthcare Limited | Health & social care | 2018 |
| Sophrology Limited | Professional & scientific | 2020 |
| Sopianae Ltd | Transport & logistics | 2019 |
| Soraya Louise Bridal Edition (UK) Ltd | Wholesale & retail | 2025 |
| Soris Properties Limited | Real estate | 1990 |
| Sorrec (JG) Limited | Construction | 2017 |
| Sorrec Holdings Limited | Financial services | 2016 |
| Sorrec Limited | Construction | 1978 |
| Sorrec Ventures Limited | Construction | 1984 |
| Sort YA Socials Ltd | Professional & scientific | 2025 |
| SOS Decorators Limited | Construction | 2018 |
| SOS Fashion Shows Limited | Extraterritorial | 2008 |
| Sos-Man 24/7 Ltd | Construction | 2019 |
| Sosapp Limited | Other services | 2023 |
| Sosoda Solutions Ltd | Manufacturing | 2025 |
| Soteria Asbestos Limited | Professional & scientific | 2014 |
| Soteria Care Limited | Health & social care | 2014 |
| Soteria Media Risk & Safety Group Limited | Professional & scientific | 2025 |
| Sotirios Theodosiou Limited | Health & social care | 2024 |
| Sotiris Properties Limited | Real estate | 2026 |
| Sotys Services Ltd | Real estate | 2023 |
| Soualand Ltd | Real estate | 2024 |
| Souce Financial Services Limited | Professional & scientific | 2026 |
| Souce Medics Ltd | Health & social care | 2025 |
| Souce Property Investment Ltd | Real estate | 2024 |
| Soul Bowl Collective Ltd | Construction | 2025 |
| Soul Direction Records Ltd | Wholesale & retail | 2022 |
| Soul Kicks Ltd | Wholesale & retail | 2024 |
| Soulchai Ltd | Hospitality | 2025 |
| Soulfulllivings Ltd | Wholesale & retail | 2025 |
| Soulmuppet Publishing Ltd | Manufacturing | 2021 |
| Soulsync Wellness Ltd | Health & social care | 2023 |
| Soulwood Ltd | Manufacturing | 2021 |
| Sound Cables Limited | Manufacturing | 2010 |
| Sound Computer Systems Ltd. | Extraterritorial | 1990 |
| Sound Diffusion Ltd | Extraterritorial | 2011 |
| Sound Escapes Performance Tours Ltd | Administrative & support | 2018 |
| Sound Hearing Limited | Health & social care | 2007 |
| Sound Hearing Oxford Ltd | Wholesale & retail | 2016 |
| Sound Tests Ltd | Professional & scientific | 2020 |
| Sounding Post 2017 Ltd | Administrative & support | 2017 |
| Sounds and Colours Limited | Information & communication | 2015 |
| Sounds Promising Limited | Information & communication | 2013 |
| Sounds Queer Productions Ltd | Arts & recreation | 2022 |
| Souni Accounting Ltd | Professional & scientific | 2024 |
| Souni Automation Ltd | Professional & scientific | 2025 |
| Soupe Pilates Ltd | Other services | 2025 |
| Souplex Properties Ltd | Real estate | 2018 |
| Source Bioscience Asset Management Limited | Households | 2020 |
| Source Bioscience Limited | Administrative & support | 1903 |
| Source Bioscience Nominees Limited | Professional & scientific | 2026 |
| Source Bioscience UK Limited | Administrative & support | 2000 |
| Source FP Limited | Construction | 2013 |
| Source Genomics Limited | Professional & scientific | 2022 |
| Source Healthcare Ltd | Wholesale & retail | 2017 |
| Source Property Investments Ltd | Real estate | 2019 |
| Source Twenty Eight Limited | Arts & recreation | 2011 |
| SOURCE24 Limited | Information & communication | 2010 |
| Sourceandmedia Limited | Information & communication | 2024 |
| Sourcebio International Limited | Professional & scientific | 2016 |
| Sourcedbyajay Ltd | Wholesale & retail | 2020 |
| Sourcesmart Talent Recruitment Ltd | Administrative & support | 2025 |
| Soushian Ltd | Construction | 2025 |