| Spencer Property Group Ltd | Real estate | 2025 |
| Spencer Solutions Web Design Ltd | Information & communication | 2021 |
| Spencer Superstars | Education | 2021 |
| Spennyfield Construction Limited | Construction | 2022 |
| Spennyfield Estates Ltd | Real estate | 2021 |
| Spenx Limited | Transport & logistics | 2024 |
| SPG Apostille & Legalisation | Other services | 2022 |
| SPG Construction Management Ltd | Administrative & support | 2023 |
| SPG Innovation Limited | Manufacturing | 2015 |
| SPG Installations Limited | Construction | 2015 |
| Sphinx International Ltd | Professional & scientific | 2016 |
| Sphinx Management Consulting Ltd | Professional & scientific | 2023 |
| Sphinx's Property and Lettings Ltd | Real estate | 2025 |
| Spice and Suave Restaurant Ltd | Hospitality | 2025 |
| Spice CAY Ltd | Hospitality | 2022 |
| Spice House Notts Ltd | Hospitality | 2022 |
| Spice Nottingham Limited | Hospitality | 2016 |
| SPICE2NIGHT Ltd | Hospitality | 2025 |
| Spiceland Eatery Limited | Hospitality | 2023 |
| Spider OPS Ltd | Administrative & support | 2021 |
| Spidergap Ltd | Information & communication | 2014 |
| Spiderweb Digital Marketing Solutions Ltd | Professional & scientific | 2024 |
| Spikey Hedgehog Limited | Administrative & support | 2012 |
| Spine Care Group Limited | Health & social care | 2019 |
| Spine Consultants Ltd | Health & social care | 2005 |
| Spineside Limited | Financial services | 2015 |
| Spinex Disc Clinics Limited | Health & social care | 2014 |
| Spinrock Supplies Ltd | Wholesale & retail | 2025 |
| Spiral Joinery Limited | Construction | 2014 |
| Spire Planing Limited | Construction | 2023 |
| Spirit Commercial Property Limited | Real estate | 1994 |
| Spirit Eagle Cheerleaders CIC | Education | 2019 |
| Spirit of Sherwood Limited | Manufacturing | 2021 |
| Spirit Pathways Ltd | Real estate | 2025 |
| Spirit Sanctuary Ltd | Wholesale & retail | 2019 |
| Spirit Vitale Ltd | Wholesale & retail | 2024 |
| Spiritual Development Events Ltd | Other services | 2013 |
| Spiritual Mother Hustlers Ltd | Wholesale & retail | 2024 |
| Spit NOT Rinse Dental Ltd | Health & social care | 2025 |
| Spitfire Studio Ltd | Professional & scientific | 2010 |
| Spkpap Properties Limited | Real estate | 2026 |
| SPL Forklifts Ltd | Administrative & support | 2022 |
| SPL Studio Services Ltd | Information & communication | 2023 |
| Splash Art Republic Birmingham Ltd | Arts & recreation | 2025 |
| Splash Art Republic Ltd | Arts & recreation | 2024 |
| Splash Art Republic Sheffield Ltd | Arts & recreation | 2026 |
| Splash Imports Limited | Wholesale & retail | 2023 |
| Splatt Ltd | Manufacturing | 2025 |
| Splendid (Midland) Ltd | Transport & logistics | 2022 |
| Splendid Rush Ltd | Arts & recreation | 2025 |
| Splice Here Ltd. | Information & communication | 2016 |
| Spludlow Limited | Information & communication | 2018 |
| Spnet Ltd. | Manufacturing | 2013 |
| SPO Executive Consulting Limited | Professional & scientific | 2018 |
| SPO Landscapes Ltd | Construction | 2025 |
| Spondon GIA Engineering Ltd | Manufacturing | 2021 |
| Spooner Property Limited | Arts & recreation | 2012 |
| Spoorthi Techno Solutions Ltd | Information & communication | 2019 |
| Spore Media Ltd | Administrative & support | 2017 |
| Sport Lived Limited | Administrative & support | 2004 |
| SPORT981 Limited | Arts & recreation | 2008 |
| Sportandart Ltd | Professional & scientific | 2022 |
| Sportdataco Limited | Information & communication | 2023 |
| Sports Events Catering Limited | Hospitality | 2022 |
| Sports Exchange (UK) Limited | Wholesale & retail | 2014 |
| Sports Gateway Limited | Arts & recreation | 2013 |
| Sports Metrics Ltd | Arts & recreation | 2013 |
| Sporttherapy/Pt Ltd | Arts & recreation | 2019 |
| Sportykidsclothing Ltd | Wholesale & retail | 2012 |
| Spot on CUE Sports Ltd | Hospitality | 2023 |
| Spot on Leisure Limited | Arts & recreation | 1988 |
| Spotfree Limited | Administrative & support | 2020 |
| Spotlesedge Services Limited | Administrative & support | 2025 |
| Spotless by Becky Ltd | Administrative & support | 2025 |
| Spotlight Cleaning Services Limited | Administrative & support | 1998 |
| Spotlight Inclusion Ltd | Education | 2022 |
| Spotlight Theatre Arts CIC | Education | 2024 |
| Spotlyte Marketing Ltd | Professional & scientific | 2024 |
| SPR Marketing Ltd | Professional & scientific | 2018 |
| SPR Ventures Ltd | Financial services | 2025 |
| Spray Glue UK Ltd | Wholesale & retail | 2021 |
| Spray Maestro Ltd | Construction | 2023 |
| Spraycoat Limited | Construction | 2020 |
| Spraytech Upvc Ltd | Construction | 2019 |
| Sprayways Coatings Ltd | Construction | 2024 |
| Spring (Bingham) Ltd | Hospitality | 2017 |
| Spring Close Kinsley Management Limited | Households | 2017 |
| Spring Lane Developments Limited | Construction | 2023 |
| Spring Lane Farm Limited | Wholesale & retail | 1945 |
| Spring Lane Nursing Home (Lambley) Limited | Health & social care | 1988 |
| Spring Markets Limited | Arts & recreation | 2010 |
| Spring Music Group Limited | Financial services | 2015 |
| Spring Rental Limited | Administrative & support | 2002 |
| Springacre Developments Ltd | Real estate | 2017 |
| Springboard Accounting Limited | Wholesale & retail | 2020 |
| Springbokmarketing Ltd | Professional & scientific | 2017 |
| Springfield (Nottingham) Management Limited | Hospitality | 2016 |
| Springfield Care Sunderland Limited | Health & social care | 2023 |
| Springfield Equestrian Limited | Arts & recreation | 2012 |
| Springfield Events Limited | Hospitality | 2023 |