| Sapphire Investigations Bureau Limited | Administrative & support | 1963 |
| Sapphireblu Hair and Beauty Limited | Other services | 2020 |
| Sapphirepearl | Financial services | 2025 |
| Sara Benwell Journalism & Consulting Ltd | Professional & scientific | 2020 |
| Saracens Sales Limited | Wholesale & retail | 2013 |
| Sarah Considine Physiotherapy Limited | Health & social care | 2014 |
| Sarah Downes Limited | Professional & scientific | 2010 |
| Sarah Heffer Accountancy Ltd | Professional & scientific | 2010 |
| Sarah Kerins Limited | Health & social care | 2015 |
| Sarah Knights Coaching Ltd | Other services | 2024 |
| Sarbele Labs Limited | Information & communication | 2018 |
| Sarfo & Co Ltd | Real estate | 2023 |
| Sargisson Associates Ltd | Professional & scientific | 2022 |
| Sarinas Limo & Car Service Inc Ltd | Transport & logistics | 2023 |
| Sario Partners Limited | Administrative & support | 2017 |
| Sarole Ltd | Financial services | 2011 |
| Sarson & Co Limited | Professional & scientific | 2014 |
| Sartik Consulting Ltd | Information & communication | 2016 |
| Sarumi Properties Ltd | Real estate | 2020 |
| Sarwat Chadda Ltd | Administrative & support | 2008 |
| Sarzameen Ltd | Wholesale & retail | 2025 |
| SAS Plant & Groundwork’S Ltd | Construction | 2025 |
| SAS Teesside Limited | Real estate | 2014 |
| SAS Warranty Manager Ltd | Professional & scientific | 2019 |
| Sash Window Preservation Ltd | Construction | 2012 |
| Sash Window Solutions East Anglia Limited | Construction | 2022 |
| Sashtec Limited | Construction | 2018 |
| Sasi Trading Limited | Wholesale & retail | 2023 |
| Sasplus Digital Technologies Ltd | Information & communication | 2025 |
| Sassi Amour Ltd | Wholesale & retail | 2026 |
| Sassi Squirrel Holdings Limited | Real estate | 2022 |
| SAT Naam Estates Limited | Real estate | 2026 |
| Sata Professional Services Ltd | Professional & scientific | 2021 |
| Satdee Limited | Information & communication | 2025 |
| Satellite - Health Ltd | Professional & scientific | 2012 |
| Satellite Data Solutions Ltd | Information & communication | 2022 |
| Satio Associates Ltd | Wholesale & retail | 2017 |
| Satnam Millennium Limited | Real estate | 1998 |
| Satori Martial Arts Limited | Arts & recreation | 2011 |
| Satsuma Europe Limited | Information & communication | 2010 |
| Satura Ltd | Wholesale & retail | 2025 |
| Saturn Audio Visual Limited | Construction | 2009 |
| Saturn Sails Limited | Manufacturing | 1979 |
| Saturns Olive Ltd | Real estate | 2023 |
| Satvik Investments Limited | Real estate | 2020 |
| Satys Air Livery UK Ltd | Manufacturing | 1991 |
| Sauber Energy Limited | Extraterritorial | 2013 |
| Saul D Humphrey LLP | | 2019 |
| Sauna Box Ltd | Other services | 2021 |
| Saunders Marine Consultants Ltd | Professional & scientific | 2021 |
| Savage & Co Properties Limited | Real estate | 2019 |
| Savage Developments (Norfolk) Limited | Real estate | 2023 |
| Savage Equity Ltd | Financial services | 2025 |
| Savage Golf Ltd | Arts & recreation | 2019 |
| Savelli Consultancy Limited | Administrative & support | 2008 |
| Savino Elite Advisory Ltd | Professional & scientific | 2026 |
| Saviours Yard Drinks Limited | Wholesale & retail | 2026 |
| Savnan Properties Limited | Real estate | 2026 |
| Savorland Ltd | Hospitality | 2023 |
| Savoy and New Regent Restaurants (Gt.Yarmouth) Limited | Hospitality | 1961 |
| Savrr Group Ltd | Information & communication | 2020 |
| Savrr Ltd | Extraterritorial | 2020 |
| Savva Plasterers Limited | Construction | 2003 |
| Savvyfront Limited | Information & communication | 2020 |
| Savyi Ltd | Information & communication | 2024 |
| SAW Building & Landscaping Limited | Construction | 2025 |
| SAW Property Ltd | Real estate | 2025 |
| Sawyers Electrical Ltd | Construction | 2017 |
| SAX Capital Limited | Financial services | 2019 |
| Saxan Securities Limited | Administrative & support | 1999 |
| Saxmundham Pharma Ltd | Wholesale & retail | 2023 |
| Saxon Digital Services Limited | Manufacturing | 2002 |
| Saxon Expeditions Ltd | Construction | 2025 |
| Saxon Field (Brancaster) Limited | Other services | 2026 |
| Saxon House (Watton) Management Company Limited | Real estate | 2009 |
| Saxon House Freeholders Ltd | Real estate | 2014 |
| Saxon Meadow (Wortham) Management Company Limited | Households | 2021 |
| Saxon Way Management Company Limited | Extraterritorial | 2007 |
| Saxonair Aircraft Sales Limited | Wholesale & retail | 2014 |
| Saxonair Charter Limited | Transport & logistics | 2007 |
| Saxonair Flight Support Limited | Transport & logistics | 2008 |
| Saxonair Sales Ltd | Transport & logistics | 2021 |
| Saxongate Properties Limited | Real estate | 1989 |
| Saxton & Co Ltd | Financial services | 2014 |
| Saxton & Milsom Holdings Ltd | Information & communication | 2021 |
| Saxton Bird Limited | Wholesale & retail | 2006 |
| SAY More Therapy Ltd | Health & social care | 2025 |
| SAY YES Norwich Ltd | Administrative & support | 2019 |
| Sayed Ltd | Hospitality | 2013 |
| Sayer and Sons Roofing Limited | Construction | 2024 |
| Sayer Electrical Services Limited | Construction | 2018 |
| Saylah Ltd | Real estate | 2020 |
| SAZ Business Solutions Ltd | Hospitality | 2021 |
| Sazure International Limited | Information & communication | 2016 |
| SB Activities Ltd | Health & social care | 2026 |
| SB Cleaning Solutions Ltd | Water & waste | 2012 |
| SB Collective Ltd | Administrative & support | 2014 |
| SB Southeast Ltd | Hospitality | 2024 |
| SBA Holdings Ltd | Administrative & support | 2017 |
| Sbbs Bespoke Kitchens & Bathrooms Ltd | Construction | 2022 |