| SBC Customs Ltd | Wholesale & retail | 2019 |
| SBC Groundworks Ltd | Construction | 2026 |
| SBC Supply & Consultancy Ltd | Wholesale & retail | 2025 |
| SBD Scaffolding Ltd | Construction | 2022 |
| Sbit Ltd | Information & communication | 2019 |
| SBS Communication Ltd | Wholesale & retail | 2017 |
| SBT Construction Ltd | Construction | 2025 |
| SC Monument Holdings Limited | Financial services | 2025 |
| SC Projects (Norfolk) Limited | Construction | 2025 |
| SC6 Properties Limited | Real estate | 2020 |
| Scalestop (UK) Ltd | Wholesale & retail | 2026 |
| Scalp Image Ltd | Other services | 2021 |
| Scalp Tattoo Limited | Other services | 2019 |
| Scalperfection Academy Ltd | Other services | 2023 |
| Scalperfection Ltd | Other services | 2026 |
| Scaly Ltd | Wholesale & retail | 2023 |
| Scan-Plan Ltd | Other services | 2023 |
| Scandia Building Services Limited | Extraterritorial | 2018 |
| Scandia Limited | Construction | 2000 |
| Scanglo Limited | Wholesale & retail | 1999 |
| Scanwell Logistics (UK) Limited | Transport & logistics | 2007 |
| Scaped Nature Ltd | Wholesale & retail | 2018 |
| Scarborough Hill Farm Ltd | Real estate | 2024 |
| Scarbrooke Engineering Limited | Wholesale & retail | 2015 |
| Scarlet (Norwich) Ltd | Wholesale & retail | 2013 |
| Scarlet Tiger Marketing Ltd | Professional & scientific | 2018 |
| Scarlett & Mustard Ltd | Manufacturing | 2012 |
| Scarlett Auto Services Hillside Ltd | Wholesale & retail | 2024 |
| Scarlett Auto Services Limited | Wholesale & retail | 2013 |
| Scarlett Properties (East Anglia) Limited | Real estate | 2023 |
| Scarlett Reindeer Ltd | Hospitality | 2025 |
| Scarrowbeck Limited | Arts & recreation | 2012 |
| Scdp Customs Services Ltd | Administrative & support | 2024 |
| Scenario Consulting Partners Limited | Professional & scientific | 2004 |
| Sceniq Limited | Professional & scientific | 2024 |
| Scenti Ltd | Wholesale & retail | 2019 |
| Scentkin Ltd | Wholesale & retail | 2026 |
| Sceptre Living Ltd | Real estate | 2025 |
| SCG Development Group Ltd | Construction | 2026 |
| Scheduled Anaesthesia Limited | Health & social care | 2007 |
| Schema Engineering Ltd | Administrative & support | 2016 |
| Schema Technical Ltd | Professional & scientific | 2026 |
| Schofield Family Enterprises Ltd | Financial services | 2025 |
| Scholars & Writers Limited | Information & communication | 2019 |
| Scholars Yard (Trowse) Estate Management Ltd | Real estate | 2026 |
| Scholefields Limited | Real estate | 2007 |
| Schon Fashion Ltd | Wholesale & retail | 2017 |
| School Taxis Norwich Ltd | Transport & logistics | 2023 |
| School-Advertise Limited | Professional & scientific | 2025 |
| Schram Business Services Ltd | Information & communication | 2020 |
| Schuler Properties Ltd | Real estate | 2022 |
| Scicluna Property Ltd | Real estate | 2022 |
| Science Adventures C.I.C. | Education | 2010 |
| Science Atelier Ltd | Professional & scientific | 2016 |
| Scientific Innovation and Research Trials in Africa (Sirta) Ltd | Professional & scientific | 2026 |
| Scion Fitness Ltd | Education | 2020 |
| SCK Developments Ltd | Construction | 2021 |
| SCK Properties Ltd | Real estate | 2017 |
| Sckk Defi Management Limited | Financial services | 2021 |
| SCL Residential Ltd | Real estate | 2025 |
| SCO Ruston Farms Limited | Agriculture & fishing | 1979 |
| Scoby's Ferments LLP | | 2023 |
| Scolt Head Ltd | Extraterritorial | 2026 |
| Scoops Fabrication Limited | Construction | 2019 |
| Scooter Sense (UK) Limited | Wholesale & retail | 2022 |
| Scooters Cafe Ltd | Hospitality | 2012 |
| Scoots Hire Ltd | Administrative & support | 2016 |
| Scopesource Limited | Information & communication | 2025 |
| Scott & Browne Ltd | Manufacturing | 2016 |
| Scott & Porter Ltd | Construction | 2019 |
| Scott and Pennell Roofing Limited | Construction | 2019 |
| Scott Booker Medical Services Ltd | Health & social care | 2025 |
| Scott Lewis Consulting Ltd | Professional & scientific | 2023 |
| Scott Sheds Limited | Manufacturing | 2006 |
| Scott Timber Buildings Ltd | Manufacturing | 2018 |
| Scott-James Properties Ltd | Construction | 2021 |
| Scottish Collection Limited | Wholesale & retail | 1996 |
| Scottow Farms Limited | Agriculture & fishing | 1961 |
| Scotts Bodyshop Supplies Limited | Wholesale & retail | 2021 |
| Scotts Specialized Services Ltd | Professional & scientific | 2019 |
| Scoulton Legal Services Limited | Administrative & support | 2013 |
| SCP 1 Limited | Construction | 2020 |
| Scpb INK Ltd | Professional & scientific | 2025 |
| SCR Global Limited | Transport & logistics | 2016 |
| SCR Holdings Ltd | Construction | 2019 |
| Scrat Facilitator Ltd | Wholesale & retail | 2025 |
| Screw Pile Limited | Construction | 2022 |
| Screw Pile Technology Ltd | Construction | 2020 |
| Scribe Spaces Ltd | Information & communication | 2022 |
| SCRIPT6 Limited | Information & communication | 2016 |
| Scripty Limited | Information & communication | 2026 |
| Scrumptious Buns Limited | Manufacturing | 2011 |
| Scry Business Intelligence Ltd | Information & communication | 2009 |
| Scryer Limited | Information & communication | 2017 |
| Scuba Edventures Ltd | Administrative & support | 2024 |
| SCX Consult Ltd | Professional & scientific | 2024 |
| SD Aesthetics and Beauty Ltd | Other services | 2025 |
| SD Paraplanning Services Ltd | Administrative & support | 2022 |
| SD Second CUP Ltd | Wholesale & retail | 2021 |
| SDA Corporate Ltd | Hospitality | 2019 |