| Sport Foundry Limited | Wholesale & retail | 2008 |
| Sportivity South West Limited | Arts & recreation | 2016 |
| Spraypoint Limited | Real estate | 2001 |
| Springbok (UK) Limited | Administrative & support | 2014 |
| Spurway Motors Modified Ltd | Wholesale & retail | 2025 |
| SPW Developments Ltd | Construction | 2016 |
| SRP Media Limited | Information & communication | 2010 |
| Ssquareplus Limited | Health & social care | 2023 |
| ST Dominic's House Development LLP | | 2022 |
| ST John's Road Exmouth Estate Management Company Limited | Real estate | 2018 |
| ST Mary's (Dartington) Management Company Ltd | Households | 2022 |
| ST Marychurch Rent Agency Limited | Real estate | 2011 |
| ST Marys Place Ipplepen Limited | Households | 2010 |
| ST Petroc (Padstow) Management Company Ltd | Households | 2025 |
| ST Squared Limited | Construction | 2025 |
| ST Winifred's House Management Company Limited | Households | 2010 |
| ST. Marychurch Bakery Ltd. | Wholesale & retail | 2012 |
| Staar Properties Ltd | Real estate | 2021 |
| Stack Audio Limited | Information & communication | 2011 |
| Stack Design Consultancy Limited | Professional & scientific | 2022 |
| Stag Bookkeeping Services Ltd | Professional & scientific | 2023 |
| Staging Post Consultants Ltd | Professional & scientific | 2022 |
| Stanciu Home Sweet Home Lettings Ltd | Real estate | 2025 |
| Stannary Place Limited | Real estate | 2004 |
| Star Cross Entertainment Limited | Information & communication | 2018 |
| Star Refining (London) Limited | Manufacturing | 2003 |
| Star Shipping Limited | Administrative & support | 2021 |
| Star Solutions Engineering Ltd | Manufacturing | 2017 |
| Starforlife Limited | Arts & recreation | 2021 |
| Starlight Solutions Ltd | Information & communication | 2022 |
| Start Point Flooring Ltd | Wholesale & retail | 2013 |
| Start Point Holdings Limited | Financial services | 2021 |
| Start Right Engineering Limited | Professional & scientific | 2020 |
| Statham Plumbing and Heating Ltd | Construction | 2019 |
| Staunton Property Asset Management 1 Limited | Real estate | 2012 |
| Staunton Property Investments LLP | | 2011 |
| Stay LET Legal Limited | Information & communication | 2025 |
| Staytor Homes Ltd | Real estate | 2021 |
| Staytor Ltd | Real estate | 2019 |
| Steam Plough Club | Other services | 2011 |
| Steel Inspect UK Ltd | Professional & scientific | 2021 |
| Steel Submission Limited | Manufacturing | 2023 |
| Stef Francis Limited | Wholesale & retail | 2018 |
| Stelitek UK Ltd | Manufacturing | 2021 |
| Stenenhalle Ltd | Agriculture & fishing | 2022 |
| Step by Step Counselling College LLP | | 2021 |
| Step by Step Supporting Independence Limited | Health & social care | 2001 |
| Step One Services Limited | Education | 2005 |
| Stephen Lloyd Consultancy Limited | Professional & scientific | 2022 |
| Stephenson Sails and Covers Limited | Manufacturing | 2023 |
| Steve Bristow Furniture Limited | Manufacturing | 2023 |
| Steve Bristow Stone Masonry Limited | Manufacturing | 2000 |
| Stevenson James Ltd | Administrative & support | 2004 |
| Stewart Vehicles Ltd | Wholesale & retail | 2021 |
| Stewart, Pitchford & Co. Ltd. | Financial services | 2021 |
| Still Good to Go Ltd | Wholesale & retail | 2024 |
| Stoaked Limited | Manufacturing | 2017 |
| Stock Illustrations Limited | Professional & scientific | 2009 |
| Stoke Fire Farms Ltd | Agriculture & fishing | 2021 |
| Stone Arrow Ltd | Wholesale & retail | 2015 |
| Stone Lane Gardens | Arts & recreation | 2010 |
| Stone Marine Services (South West) Limited | Agriculture & fishing | 2015 |
| Stonecutters Advisory Ltd | Administrative & support | 2026 |
| Stoneface Construction Ltd | Construction | 2018 |
| Stonehaven (Healthcare) Ltd | Health & social care | 1998 |
| Stonelodge Developments Limited | Manufacturing | 2000 |
| Stonelodge Trading Limited | Wholesale & retail | 2026 |
| Stonescript Ltd | Other services | 2014 |
| Stor Heat Pumps Limited | Construction | 2021 |
| Storefort Ltd | Real estate | 2024 |
| Storewell Limited | Administrative & support | 2024 |
| Storexe Limited | Wholesale & retail | 2014 |
| Stover Financial Planners Ltd | Financial services | 2020 |
| Stover Golf Club Limited | Arts & recreation | 2016 |
| Stradd Properties Limited | Real estate | 2023 |
| Strata Civils Ltd | Construction | 2026 |
| Strathmore House Lettings Limited | Real estate | 2021 |
| STREET1 Limited | Extraterritorial | 2016 |
| Striveon Innovations Ltd | Extraterritorial | 2024 |
| Strongpro Construction Repair Services Ltd | Construction | 2020 |
| Structure Building Contractors Limited | Construction | 2007 |
| Strydom Commercial Limited | Real estate | 2017 |
| STU CAP Ltd | Financial services | 2019 |
| Stubbins Court (Management) Limited | Households | 2008 |
| Studio Screen Print Limited | Manufacturing | 1999 |
| Subside Sports Limited | Wholesale & retail | 1994 |
| Success Ahead Limited | Professional & scientific | 2016 |
| Sugarplum Desserts UK Ltd | Manufacturing | 2025 |
| Suli Global Ltd | Financial services | 2024 |
| Summa Breeze Limited | Professional & scientific | 2018 |
| SUMMERHOUSE24 Limited | Wholesale & retail | 2024 |
| Summerland Support Ltd | Health & social care | 2003 |
| Summerlands Health Holdings Ltd | Financial services | 2019 |
| Summerlands Health Ltd | Administrative & support | 2014 |
| Summit Electrical Design and Installation Ltd | Construction | 2023 |
| Summitcouriers Ltd | Transport & logistics | 2026 |
| Sun Shipping Limited | Administrative & support | 2021 |
| Sunflower Consulting Limited | Information & communication | 1999 |
| Sunflower International Limited | Professional & scientific | 1998 |
| Sunshine and Rayn Ltd | Wholesale & retail | 2025 |