| Soby Mews Apartments Management Company Limited | Households | 2019 |
| Soccer Academy Limited | Extraterritorial | 2012 |
| Soccer Bible Limited | Information & communication | 2001 |
| Soccer Profile Ltd | Arts & recreation | 2013 |
| Social Dream Studios Ltd | Administrative & support | 2023 |
| Sodeka Ltd | Hospitality | 2023 |
| Soft Tissue Therapy Qualifications T/As Sttq Limited | Education | 2026 |
| Softwash Exteriors Ltd | Administrative & support | 2025 |
| Sol-Lec Ltd | Construction | 2024 |
| Solarus Limited | Health & social care | 2008 |
| Sole Studio Vault Ltd | Wholesale & retail | 2025 |
| Solec SW Ltd | Construction | 2015 |
| Solomon Homes Limited | Real estate | 2018 |
| Solus Interactive Ltd | Information & communication | 2026 |
| Solus West Ltd | Information & communication | 2024 |
| Somerset Living Ltd | Hospitality | 2016 |
| Somerset Lodge (Newton Abbot) Management Company Limited | Extraterritorial | 2002 |
| Sonicom Limited | Construction | 2016 |
| Sonopera CIC | Education | 2019 |
| Sophs Yard Ltd | Real estate | 2026 |
| Sopublishing Ltd | Information & communication | 2010 |
| Sorbaiano Limited | Agriculture & fishing | 2015 |
| SOS Words Limited | Professional & scientific | 2014 |
| Sostays Ltd | Real estate | 2021 |
| Sotek Engineering Ltd | Manufacturing | 2017 |
| Soul Roots Kitchen Limited | Professional & scientific | 2019 |
| Soulfuliscious Ltd | Hospitality | 2025 |
| Sound Holdings Limited | Financial services | 2023 |
| Souplesse Designs Limited | Manufacturing | 2021 |
| Source (South West) Ltd | Real estate | 2024 |
| Source Point Botanicals CIC | Health & social care | 2024 |
| Source Point Community Health C.I.C. | Health & social care | 2014 |
| South Coast Timber Framing Ltd | Construction | 2025 |
| South Devon Accountancy Ltd | Professional & scientific | 2020 |
| South Devon Accounting Ltd | Professional & scientific | 2017 |
| South Devon Appliance Repairs Limited | Other services | 2024 |
| South Devon Barbers Ltd | Other services | 2023 |
| South Devon Care Limited | Other services | 2026 |
| South Devon Care Services Limited | Health & social care | 2002 |
| South Devon Dining Ltd | Real estate | 2024 |
| South Devon Doors Limited | Construction | 2024 |
| South Devon Firewood Limited | Agriculture & fishing | 2026 |
| South Devon Homes Developments Ltd | Construction | 2023 |
| South Devon Hospitality Holdings Limited | Financial services | 2021 |
| South Devon Hospitality Limited | Hospitality | 2015 |
| South Devon Inns Limited | Hospitality | 1999 |
| South Devon Locksmiths Limited | Administrative & support | 2014 |
| South Devon Orthopaedic Clinic Limited | Health & social care | 2017 |
| South Devon Properties Limited | Real estate | 2020 |
| South Devon Property Management Ltd | Households | 2011 |
| South Devon Roofing Limited | Construction | 2018 |
| South Devon School of Gymnastics | Arts & recreation | 2009 |
| South Devon Shoulder Specialist Ltd | Health & social care | 2010 |
| South Eleven Limited | Wholesale & retail | 2025 |
| South Hams Anaesthesia and Critical Care Limited | Health & social care | 2017 |
| South Rock Developments Ltd | Construction | 2023 |
| South West Beauty Expo & Trade Show Ltd | Administrative & support | 2025 |
| South West Capital Ltd | Real estate | 2026 |
| South West Coaching Ltd | Professional & scientific | 2011 |
| South West Estate Agents Ltd | Real estate | 2024 |
| South West Laparoscopic Surgery Limited | Health & social care | 2019 |
| South West Laundry Solutions Limited | Administrative & support | 2015 |
| South West Lifts Limited | Manufacturing | 2011 |
| South West Motocross Club Limited | Arts & recreation | 2001 |
| South West Powder Coating Ltd | Manufacturing | 2021 |
| South West Remaps Ltd | Professional & scientific | 2023 |
| South West Streamers Ltd | Wholesale & retail | 2026 |
| South West Surgical Courses Limited | Health & social care | 2024 |
| South Western AID Limited | Construction | 2005 |
| Southern Design Windows Ltd | Wholesale & retail | 2023 |
| Southern Tree Services Limited | Agriculture & fishing | 2003 |
| Southern Wharfage Limited | Administrative & support | 2018 |
| Southfield Garage (Devon) Ltd | Wholesale & retail | 2007 |
| Southview (Torquay) Management Company Ltd | Households | 2011 |
| Southwest Building Group Ltd | Construction | 2025 |
| Southwest ISO Systems Ltd | Agriculture & fishing | 2017 |
| Southwestcio Limited | Information & communication | 2018 |
| Sowerbys Slabs Ltd | Construction | 2023 |
| Space to Breathe Therapy Ltd | Health & social care | 2021 |
| Spaceman Productions Limited | Information & communication | 2001 |
| Spanishlake Limited | Education | 2002 |
| Spare VET Direct Ltd | Professional & scientific | 2022 |
| Sparkle and Shine Cleaning Solutions Ltd | Administrative & support | 2025 |
| Sparkworld Limited | Wholesale & retail | 1985 |
| Sparnham Fields Ashburton Company Limited | Agriculture & fishing | 2010 |
| Sparnham House Management Company Limited | Households | 2003 |
| SPC Rail Operations Limited | Transport & logistics | 2021 |
| Specialist Wheel Solutions Limited | Wholesale & retail | 2010 |
| Spectre Security Solutions Limited | Administrative & support | 2016 |
| Spectrum Coatings Alloy Wheel Refurbishment Ltd | Wholesale & retail | 2026 |
| SPF Painters Ltd | Construction | 2022 |
| Spicer Designs Limited | Wholesale & retail | 2003 |
| Spirit ASH Limited | Wholesale & retail | 2019 |
| Spirit Base Limited | Other services | 1986 |
| Spiritus Marketing Limited | Professional & scientific | 2023 |
| Splice Media Ltd | Information & communication | 2004 |
| SPM Solutions Limited | Real estate | 2010 |
| Sponsorship & Programme Planning Ltd. | Professional & scientific | 1990 |
| Spooner Shopfitting Limited | Construction | 2013 |
| Sport and Active Education Ltd | Education | 2025 |