| Share the Love Holdings Ltd | Financial services | 2021 |
| Shared Decision Making Charts Ltd | Information & communication | 2023 |
| Shared Lives South West | Health & social care | 2004 |
| Sharetry Property Management Limited | Households | 1989 |
| Shawbrook Corporation Limited | Wholesale & retail | 1993 |
| Shearston Ltd | Construction | 2018 |
| Sheds to Last Limited | Manufacturing | 2017 |
| Shelanda Holdings Ltd | Financial services | 2025 |
| Sheldon Dog Shop Ltd | Wholesale & retail | 2023 |
| Sherborne Corporate Services Limited | Other services | 2003 |
| Sherifa Designs Limited | Information & communication | 2011 |
| Sherwood Carpentry SW Limited | Construction | 2014 |
| Sherwoods (SW) Limited | Construction | 2003 |
| Sherwoods FM Group Ltd | Financial services | 2024 |
| Shhhopping Ltd | Administrative & support | 2025 |
| Shillabeer Decorators Limited | Construction | 2013 |
| Shine Brightly Consulting Ltd | Professional & scientific | 2023 |
| Shiny Happy People Services Ltd | Professional & scientific | 2007 |
| Shipwrights Arms (Shaldon) Ltd | Hospitality | 2019 |
| Shockwave Therapy Limited | Health & social care | 2016 |
| Shore Assets Ltd | Financial services | 2024 |
| Shore Group Ltd | Construction | 2022 |
| Short Breaks Direct Limited | Extraterritorial | 2000 |
| Shout Websites Ltd. | Professional & scientific | 2013 |
| Shug Limited | Real estate | 2023 |
| Shwc Limited | Construction | 2021 |
| Sigillite Games Ltd | Wholesale & retail | 2025 |
| Sigma Group SW Ltd | Professional & scientific | 2016 |
| Sign Art South West Ltd. | Manufacturing | 2005 |
| Signal Laboratories Ltd | Professional & scientific | 2026 |
| Signature Cars - Torbay Limited | Wholesale & retail | 2015 |
| Signature Pools & Leisure Limited | Administrative & support | 2008 |
| Signature Pools Limited | Extraterritorial | 2010 |
| Signature Wellness Limited | Wholesale & retail | 2009 |
| Sijh Ltd | Professional & scientific | 2010 |
| Silent Whistle 1 Ltd | Hospitality | 2023 |
| Silvalea Limited | Manufacturing | 2002 |
| Silver Lion Jewellers (Woodscott) Ltd | Wholesale & retail | 2018 |
| Silver Trees Services Ltd | Education | 2019 |
| Silverlawns Management Company Limited | Households | 2018 |
| Silverway 2018 Limited | Hospitality | 2017 |
| Silverwood Property Limited | Real estate | 2000 |
| Simon Chaudoir Limited | Professional & scientific | 2002 |
| Simon Snell Consultancy & Training Limited | Professional & scientific | 2013 |
| Simply Detailing Devon Ltd | Administrative & support | 2025 |
| Simply Green Estate Agents Ltd | Real estate | 2021 |
| Simply Occupational Health Limited | Health & social care | 2008 |
| Simply Proofreading Limited | Information & communication | 2011 |
| Simpson Operations Ltd | Professional & scientific | 2026 |
| Singularity (UK) Ltd | Information & communication | 2009 |
| Singularity UK Holdings Ltd | Administrative & support | 2010 |
| Sirius Projects Limited | Construction | 2004 |
| Sirmione Investments Ltd | Extraterritorial | 2024 |
| Sister SKI Ltd | Administrative & support | 2025 |
| Sitorus Limited | Information & communication | 2010 |
| SJ Newton Electrical Limited | Construction | 2010 |
| SJB Signs Ltd | Other services | 2014 |
| SJN Carpentry Limited | Manufacturing | 2023 |
| SK Developments (Devon) Ltd | Construction | 2004 |
| Skaigh Engineering MBO Limited | Financial services | 2019 |
| Skate to the MAX CIC | Education | 2020 |
| Skilltopia Ltd | Education | 2025 |
| Skntiq Collective Ltd | Wholesale & retail | 2025 |
| Skovva Limited | Construction | 2024 |
| Sky BLU SW Limited | Real estate | 2019 |
| Sky Shipping Limited | Administrative & support | 2021 |
| Skyclimbers Scaffolding Limited | Construction | 2020 |
| Skydive UK Limited | Transport & logistics | 2015 |
| Skyflicks Limited | Information & communication | 2024 |
| Skylight Broadband Ltd | Information & communication | 2014 |
| Skyline Fabrications Ltd | Manufacturing | 2025 |
| Skysprouts Limited | Agriculture & fishing | 2018 |
| Slam Pinball Ltd | Wholesale & retail | 2025 |
| Sleeman & Hawken Limited | Construction | 1958 |
| Slidepods Ltd | Manufacturing | 2020 |
| Sliding Doors and Windows Limited | Manufacturing | 1980 |
| Sliding Doors Holdings Ltd | Financial services | 2021 |
| Slmb Limited | Professional & scientific | 2021 |
| Sloane & Pirkis LLP | | 2012 |
| SM Buildrite Limited | Construction | 2022 |
| SM16 Limited | Extraterritorial | 2016 |
| Smart Build Supplies Ltd | Wholesale & retail | 2012 |
| Smart Investments and Properties Limited | Real estate | 2012 |
| Smart Syndicate Ltd | Information & communication | 2023 |
| Smartframes South West Ltd | Manufacturing | 2015 |
| SMC Training Service Ltd | Education | 2018 |
| Smile Jewellery Limited | Wholesale & retail | 2022 |
| Smile Locum Agency Ltd | Administrative & support | 2009 |
| Smile Whitest Ltd | Administrative & support | 2016 |
| Smiles Chiropractic Limited | Health & social care | 2021 |
| Smith & Co (Business Services) Limited | Professional & scientific | 2012 |
| Smith Scaffolding South West Ltd | Construction | 2018 |
| Smokd Restaurant Group Ltd | Hospitality | 2021 |
| Smokeless Energy Ltd | Construction | 2014 |
| SMS Drywall Holdings Ltd | Construction | 2018 |
| SMS Drywall Limited | Construction | 2001 |
| SMW Property Solutions Ltd | Real estate | 2026 |
| SNK Hair & Beauty Ltd | Other services | 2022 |
| Snoozymoo Ltd. | Wholesale & retail | 2021 |
| SO Nuts Donuts Ltd | Hospitality | 2019 |