| SAM Allen Gardens Ltd | Administrative & support | 2025 |
| SAM Davies Building Ltd | Construction | 2019 |
| SAM Houlson Psychology Ltd | Professional & scientific | 2022 |
| SAM Maris Construction Ltd | Construction | 2021 |
| Sam's Community Care Ltd | Health & social care | 2024 |
| Samara Investments (2000) Limited | Construction | 2000 |
| Samara Investments Limited | Construction | 1996 |
| Sampson Europe Ltd | Other services | 2012 |
| Sams GAS Ltd | Construction | 2018 |
| Sand Developments Ltd | Construction | 2024 |
| Sanders & Company Accountants Limited | Professional & scientific | 2003 |
| Sandford Orleigh Management Company Limited | Households | 2001 |
| Sandhope Castle Properties Ltd | Real estate | 2020 |
| Sandwich Holdings Ltd | Financial services | 2022 |
| Sandyhayes Holdings Limited | Financial services | 2016 |
| Sansom Engineering Limited | Construction | 2024 |
| Sarah Perry Consulting Ltd | Professional & scientific | 2015 |
| Sarah Skinner Ltd | Professional & scientific | 2025 |
| Sarney Limited | Construction | 2016 |
| Saroafrica Limited | Manufacturing | 2020 |
| SAS Safe and Secure Ltd | Real estate | 2013 |
| SAS Taxis Ltd | Transport & logistics | 2020 |
| SAS Window Cleaning Limited | Administrative & support | 2023 |
| Satoshi ATM UK Ltd | Financial services | 2019 |
| Saunders & Lingard (Teignbridge) Limited | Administrative & support | 2012 |
| Saveurs... Limited | Manufacturing | 2007 |
| Sawdye & Harris (Land & Estate Agents) Ltd | Real estate | 2004 |
| Sawyer Investments Ltd | Real estate | 2012 |
| Sbsm Trustees Limited | Professional & scientific | 2023 |
| Sbuk Consultants Limited | Professional & scientific | 2023 |
| SC Retreats Ltd | Education | 2024 |
| Scaffold Structures Ltd | Construction | 2017 |
| Scarlett Entertainment & Management Holdings Ltd | Financial services | 2015 |
| Scarlett Entertainment & Management Ltd | Arts & recreation | 2011 |
| Scarlett Production House Limited | Extraterritorial | 2016 |
| Sceneguard UK Ltd | Administrative & support | 2018 |
| Scenius Media Limited | Information & communication | 2022 |
| School of Myth Ltd | Education | 2019 |
| School Road Industrial Units Limited | Real estate | 2023 |
| Schools in Limited | Education | 2002 |
| Schoolscapes UK Limited | Construction | 2025 |
| Scibotics Limited | Extraterritorial | 2008 |
| Scilight Limited | Extraterritorial | 2015 |
| Scirid Limited | Professional & scientific | 2013 |
| Scitrack Limited | Extraterritorial | 2015 |
| Scoffl Limited | Information & communication | 2025 |
| Scoops Kingsbridge Limited | Manufacturing | 2014 |
| Scoriton Show Limited | Arts & recreation | 2025 |
| Scott Dodgson Limited | Financial services | 2019 |
| Scott Legg Construction Limited | Construction | 2016 |
| Scott Mcroy Design & Illustration Ltd | Arts & recreation | 2016 |
| Screaming Abdabs Limited | Professional & scientific | 2017 |
| Screw UK Ltd | Wholesale & retail | 2023 |
| SDA (SW) Ltd | Health & social care | 2019 |
| Sdhd (Lucius Street) Limited | Construction | 2026 |
| SDR Maintenance Limited | Construction | 2019 |
| Sdvc Limited | Construction | 2021 |
| SE Francis Holdings Ltd | Financial services | 2026 |
| Sea Arch Drinks Ltd | Wholesale & retail | 2018 |
| Sea Cottage Lettings Limited | Hospitality | 2021 |
| Seacrest Construction Limited | Construction | 2008 |
| Seafield Hotel (Paignton) Limited | Hospitality | 1978 |
| Seaglass Management Company Limited | Households | 2014 |
| Seahopper Ltd | Manufacturing | 2008 |
| Sealants and Tools Direct Limited | Wholesale & retail | 2010 |
| Seale Hayne Estates Limited | Real estate | 2019 |
| Sean Clarke Accountancy Ltd | Professional & scientific | 2013 |
| Seapro Ltd | Professional & scientific | 2024 |
| Seashore Leisure Limited | Construction | 1991 |
| Seaways Menear Road Management Company Limited | Households | 2019 |
| Secure Sites SW LLP | | 2018 |
| Secureforce Holdings Ltd | Administrative & support | 2025 |
| Secureforce UK Limited | Administrative & support | 2008 |
| See.Saw Communications Limited | Professional & scientific | 2014 |
| Seedlings Pre-School Limited | Education | 2004 |
| SEG M.E.P Ltd | Construction | 2022 |
| Segen Homes Limited | Real estate | 2023 |
| Segen Living Limited | Real estate | 2019 |
| Seldons Estate Agents Limited | Real estate | 2010 |
| Select (Architectural Ironmongery) Limited | Construction | 1992 |
| Select Motorhomes Ltd | Wholesale & retail | 2023 |
| Select Motorhomes Service Centre Ltd | Wholesale & retail | 2024 |
| Sense Ability Therapy C.I.C. | Health & social care | 2015 |
| Sensor Technologies Limited | Professional & scientific | 2018 |
| Sentmore Limited | Hospitality | 2010 |
| Seocro Limited | Professional & scientific | 2012 |
| Seraphina Properties Limited | Construction | 2016 |
| Serenity Stays Ltd | Hospitality | 2022 |
| Seriously Good Landscapes Ltd | Administrative & support | 2014 |
| Seris Software Ltd | Information & communication | 2024 |
| Services for Good Limited | Information & communication | 2024 |
| SET88 Limited | Professional & scientific | 2010 |
| Settlr Group Ltd | Professional & scientific | 2026 |
| Severn Subsea Ltd. | Administrative & support | 2011 |
| Sevovdent Limited | Health & social care | 2025 |
| SFB Trading Limited | Real estate | 2011 |
| Shamrock Taxis Limited | Transport & logistics | 2024 |
| Shande Fishing Limited | Real estate | 2021 |
| Shane Reavey Mortgages Ltd | Financial services | 2025 |
| Shapley Tech Ltd. | Information & communication | 2013 |