| Roadform Renewables Ltd | Extraterritorial | 1992 |
| Roaming Heat Ltd | Health & social care | 2025 |
| ROB Cocks Limited | Agriculture & fishing | 2017 |
| Robin Lace Ltd | Wholesale & retail | 2023 |
| Robinfix Limited | Construction | 1994 |
| Roborough Terrace Management Company Limited | Households | 2001 |
| Rock City Stage Crew Limited | Administrative & support | 2002 |
| Rock Garden Ltd | Hospitality | 2019 |
| Rock Mens Salon Limited | Other services | 2010 |
| Rockbed South West Ltd | Construction | 2019 |
| ROD Hudson Pools Limited | Administrative & support | 2019 |
| Rokstar (SW) Ltd | Real estate | 2019 |
| Romacoat Limited | Professional & scientific | 2016 |
| Roman Contracting Ltd | Construction | 2025 |
| RON Campion Furnishers Limited | Wholesale & retail | 2004 |
| ROOT2GROWTH Limited | Professional & scientific | 2018 |
| Rooted Hydration Ltd | Wholesale & retail | 2026 |
| Roots Greengrocer Limited | Wholesale & retail | 2016 |
| Roots Media CIC | Wholesale & retail | 2025 |
| Rose England Limited | Professional & scientific | 2018 |
| Rose Hill Close Management Company Limited | Households | 1999 |
| Rosehirst Limited | Health & social care | 2004 |
| Roseland Enterprises Ltd | Wholesale & retail | 2021 |
| Roseland Heathfield Ltd | Water & waste | 2001 |
| Rosemill Lettings Ltd | Households | 2020 |
| Rosemoor Homes Ltd | Construction | 2014 |
| Rosemount Gardens (Property Management) Company Limited | Households | 2008 |
| Rosemount RTM Company Limited | Households | 2024 |
| Rosie Walker Limited | Financial services | 2016 |
| Roskear Minerals LLP | | 2020 |
| Roslin Medical Ltd | Health & social care | 2016 |
| Rotini Group Limited | Manufacturing | 2019 |
| Roubaix Ltd | Wholesale & retail | 2017 |
| Routeshoot Limited | Information & communication | 2012 |
| Rowantree (Management Company) Limited | Real estate | 2008 |
| Roza Coffee Ltd | Hospitality | 2021 |
| RPS Property Limited | Real estate | 2020 |
| RS Enamel Limited | Health & social care | 2025 |
| RS Properties (Devon) Limited | Real estate | 2013 |
| RSC Coffees Ltd | Wholesale & retail | 2023 |
| RTL Projects Ltd | Real estate | 2015 |
| RTR Lettings Limited | Real estate | 2025 |
| Ruby Ventures Limited | Agriculture & fishing | 2004 |
| Ruby Violet Limited | Manufacturing | 2011 |
| Ruby Workshop Ltd | Wholesale & retail | 2015 |
| Rudiraine Ltd | Manufacturing | 2026 |
| Ruffarchitects Limited | Professional & scientific | 2014 |
| Rufstone Limited | Professional & scientific | 2021 |
| Rumour Wine Bar and Restaurant Limited | Hospitality | 2017 |
| Running Deer C.I.C. | Arts & recreation | 2011 |
| Running Point Recruitment Ltd | Administrative & support | 2025 |
| Rupert Lane Woodlands Ltd | Agriculture & fishing | 2015 |
| Rupp & Fraser LLP | | 2025 |
| Rural Foundations C.I.C | Construction | 2009 |
| Ryan Flory Estates Ltd | Real estate | 2022 |
| Rydon Court 01 Limited | Real estate | 2016 |
| Rydon Farm Ltd | Agriculture & fishing | 2015 |
| S & C Marketing Ltd | Professional & scientific | 2023 |
| S & J Fishing Limited | Agriculture & fishing | 2016 |
| S & M Vehicle Repairs Limited | Wholesale & retail | 2004 |
| S & S Cleaning Services (SW) Ltd | Administrative & support | 2014 |
| S C I Holdings Limited | Professional & scientific | 1990 |
| S Clarke Commercials Limited | Wholesale & retail | 2008 |
| S Draper Limited | Construction | 2012 |
| S Judge Ltd | Health & social care | 2019 |
| S Oliver Services Limited | Administrative & support | 2018 |
| S&A Buildco Ltd | Construction | 2026 |
| S-Studios Productions Ltd | Wholesale & retail | 2025 |
| S. & S.W. Enterprises Limited | Real estate | 2009 |
| S.C.I. Masonry Limited | Construction | 1983 |
| S2AB Ltd | Wholesale & retail | 2018 |
| Saabits Limited | Wholesale & retail | 2015 |
| Sabre Buildings Management Company Limited | Real estate | 2005 |
| Sabre Recovery and Rescue Limited | Administrative & support | 2024 |
| Saddling Solutions Limited | Wholesale & retail | 2021 |
| Sadler Green Management Company Limited | Real estate | 2018 |
| Safe and Secure 24 South West Limited | Administrative & support | 2009 |
| Safe Space One Ltd | Information & communication | 2021 |
| Safebreaks Devon CIC | Health & social care | 2019 |
| Safebreaks Ltd | Health & social care | 2025 |
| Safecar Security Services Limited | Construction | 1971 |
| Safeguarding Associates for Excellence Limited | Education | 2015 |
| Safeheat (Torbay) Limited | Construction | 1998 |
| Safety Objectives Ltd | Professional & scientific | 2025 |
| Sage COX Ltd | Construction | 2023 |
| Sage Lettings Limited | Real estate | 2025 |
| Sage of Britannia Limited | Wholesale & retail | 2010 |
| Sajawo Ltd | Administrative & support | 2025 |
| Sakura Martial Arts (Devon) Limited | Arts & recreation | 2019 |
| Sakura Yamamoto Limited | Wholesale & retail | 2023 |
| Salamander Stoves Ltd | Wholesale & retail | 2012 |
| Salcombe Meat Company Limited | Manufacturing | 2016 |
| Sales Chain Limited | Real estate | 2000 |
| Salisbury Villa Limited | Health & social care | 2007 |
| Salitacreations Ltd | Manufacturing | 2022 |
| Sally Wonnacott Ltd | Professional & scientific | 2012 |
| Saltern Group Limited | Other services | 2025 |
| Salty Dog Productions Limited | Professional & scientific | 2023 |
| Salty’S Studio Ltd | Wholesale & retail | 2019 |
| Salw Ltd | Other services | 2023 |