| Sunshine Care Limited | Health & social care | 2001 |
| Sunwrey Ltd | Information & communication | 2023 |
| Supa Roofing & Power Tools Limited | Wholesale & retail | 1971 |
| Supastrikers DAC Ltd | Arts & recreation | 2024 |
| Super Audio Mastering Limited | Other services | 2001 |
| Superior South West Ltd | Construction | 2023 |
| Supernova Records Limited | Professional & scientific | 1997 |
| Supported Living Property Network Ltd | Financial services | 2022 |
| Surefire Logistics Solutions Ltd | Administrative & support | 2021 |
| Surfmore Ltd | Real estate | 1997 |
| Surplus Plumbing Supplies Limited | Construction | 2017 |
| Suso Limited | Professional & scientific | 2018 |
| Sustainable Healthcare Coalition Limited | Other services | 2023 |
| Sustvox Global Ltd | Extraterritorial | 2020 |
| Sustvox Ltd | Information & communication | 2019 |
| Sutton Court Trading Limited | Professional & scientific | 2010 |
| Suzanne Williams Estate Agents Ltd | Real estate | 2024 |
| SV Carpentry & Building Services Ltd | Construction | 2020 |
| SV02 Ltd | Information & communication | 2002 |
| SW ARB & Fencing Ltd | Administrative & support | 2015 |
| SW Comms Ltd | Wholesale & retail | 2024 |
| SW Sessions Ltd | Education | 2024 |
| SW Staff Agency Limited | Hospitality | 2018 |
| SW Wash Ltd | Administrative & support | 2021 |
| Swallow Heights Management Company Ltd | Households | 2024 |
| Swaye Electrical Services Ltd | Construction | 2016 |
| Swbaa Ltd | Health & social care | 2025 |
| Swimfix Limited | Wholesale & retail | 2004 |
| Swishup Limited | Wholesale & retail | 2007 |
| Swisstone Limited | Manufacturing | 2015 |
| SWJ Renewables Limited | Professional & scientific | 2021 |
| Swlabour Ltd | Wholesale & retail | 2019 |
| Sworn Ltd | Manufacturing | 2025 |
| SWS Hardware Limited | Extraterritorial | 2026 |
| SWS0618 Ltd | Wholesale & retail | 2018 |
| Sygl Ltd | Construction | 2024 |
| Sylvan Property Enterprise Limited | Real estate | 2026 |
| Synergy Holdings (SW) Limited | Financial services | 2022 |
| Synergy PHR Limited | Construction | 2012 |
| Synergy Solar Limited | Construction | 2023 |
| Synoviax Ltd | Wholesale & retail | 2025 |
| System 16 Ltd | Construction | 2024 |
| System Marine Ltd | Manufacturing | 2022 |
| T & E Fire and Security Ltd | Construction | 2017 |
| T a Consultancies Ltd | Wholesale & retail | 2016 |
| T C Electrics Limited | Construction | 2015 |
| T C Property Management Limited | Real estate | 2012 |
| T J Imports Ltd | Wholesale & retail | 2017 |
| T P O'Connor Limited | Arts & recreation | 1999 |
| T S Surfacing Ltd | Construction | 2023 |
| T Stepney Building Contractors Limited | Construction | 2013 |
| T. Horton & SON Limited | Administrative & support | 2000 |
| T.C.S Controls Holdings Ltd | Financial services | 2019 |
| T.C.S Controls Ltd | Manufacturing | 2006 |
| T.J.W Logistics Group Ltd | Administrative & support | 2020 |
| T.J.W Quality Homes Limited | Real estate | 2023 |
| T2 Partnership Ltd | Construction | 2012 |
| Tafimages Limited | Manufacturing | 2023 |
| Tagir Holdings Limited | Financial services | 2024 |
| Taiko South West CIC | Arts & recreation | 2020 |
| Talisman Advisors Limited | Professional & scientific | 2004 |
| Talking Slides Ltd | Arts & recreation | 2011 |
| Tamar & Provincial Properties Limited | Real estate | 2010 |
| Tamar Coaches Ltd | Transport & logistics | 2016 |
| Tamara Harrison & Co Ltd | Professional & scientific | 2017 |
| Tamarisk Invested Limited | Administrative & support | 2015 |
| Tamarisk Psychology Services Ltd | Health & social care | 2018 |
| Tapper & Sons (Newton Abbot) Limited | | 1956 |
| Tara Foster Consulting Limited | Professional & scientific | 2014 |
| Target Health Solutions Limited | Health & social care | 2020 |
| Tarkaten Ltd | Administrative & support | 2023 |
| Tarrs Construction Ltd | Administrative & support | 2017 |
| Task Force Matters Ltd | Professional & scientific | 2017 |
| Tasty Source Ltd | Hospitality | 2022 |
| Tasty Tatties Ltd | Hospitality | 2024 |
| Taunton Chiropractic Clinic Limited | Other services | 2019 |
| Tax and Financial Solutions Limited | Professional & scientific | 2016 |
| Taylor & Bolan Building Services Ltd | Construction | 2024 |
| Taylor Allen Management Services Limited | Wholesale & retail | 1985 |
| Taylored Solutions Global Ltd | Financial services | 2025 |
| TCA Anaesthesia Ltd | Health & social care | 2024 |
| TCS EOT Ltd | Administrative & support | 2025 |
| TD Towing Ltd | Transport & logistics | 2024 |
| Tdssw Limited | Education | 2018 |
| Team Tiling Ltd | Construction | 2017 |
| Team TQ Ltd | Administrative & support | 2019 |
| Team Turner LLP | | 2025 |
| Teamworx Limited | Extraterritorial | 2018 |
| Techceptional Group Ltd | Other services | 2020 |
| Technique Project Management Limited | Financial services | 2000 |
| Technique Property Services Limited | Construction | 1980 |
| Tecsw Ltd | Extraterritorial | 2021 |
| Tectorio Limited | Construction | 2017 |
| Tedium Ltd | Real estate | 2025 |
| Teef Ltd | Wholesale & retail | 2024 |
| TEH (Holdings) Limited | Financial services | 2012 |
| Teign Angels Ltd | Health & social care | 2021 |
| Teign House Management Ltd | Households | 2014 |
| Teign Housing. | Real estate | 2002 |
| Teign Tile & Stone Limited | Construction | 2019 |