| DSB Property Holdings Limited | Real estate | 2018 |
| DSD Network Marketing Ltd | Other services | 2013 |
| Dsigns Devon Limited | Professional & scientific | 2013 |
| DTM Grab Hire Ltd | Administrative & support | 2014 |
| DTN Properties Ltd | Real estate | 2025 |
| DTS Ecology Ltd | Agriculture & fishing | 2023 |
| DTS Traffic Management Ltd | Agriculture & fishing | 2023 |
| DTS Tree Consultancy Ltd | Agriculture & fishing | 2023 |
| Dudley Gardens Management Company Limited | Real estate | 2012 |
| Duncan Propellers Holdings Limited | Manufacturing | 2009 |
| Duncan Propellers Limited | Manufacturing | 2004 |
| Dunns Group Ltd | Construction | 2025 |
| DUO Manufacturing Ltd | Manufacturing | 1975 |
| Dutluk Ltd | Hospitality | 2025 |
| Dutton & Haddy - Renewable Energy Services & Technologies Ltd | Construction | 2011 |
| DUX Enterprises Limited | Information & communication | 2014 |
| DV7 Productions Ltd | Arts & recreation | 2025 |
| DVC Property Holdings Ltd | Financial services | 2026 |
| Dwyer Group Holdings Limited | Financial services | 2024 |
| Dyke Road Health Clinic Limited | Health & social care | 1998 |
| Dymacore Ltd | Mining & quarrying | 2014 |
| Dyme Consulting Group Limited | Administrative & support | 2022 |
| Dynatron Radio Limited | Manufacturing | 2015 |
| Dyson Fairclough Ltd | Arts & recreation | 2024 |
| D’Artagnan House C.I.C. | Health & social care | 2023 |
| E & J Housing Limited | Construction | 2020 |
| E B Janes Limited | Extraterritorial | 2017 |
| E Lawson Advisory Limited | Professional & scientific | 2018 |
| E. & J. W. Glendinning (Holdings) Limited | Mining & quarrying | 1995 |
| E.And J.W.Glendinning Limited | Mining & quarrying | 1958 |
| E.T.Pickworth & SON Limited | Agriculture & fishing | 1960 |
| Early Intervention Knee Clinic Limited | Health & social care | 2022 |
| Earthbound Gifts Ltd | Wholesale & retail | 2025 |
| Earthbound Treasures Ltd | Wholesale & retail | 2024 |
| Earthcult Ltd | Other services | 2023 |
| Earzz Limited | Manufacturing | 2021 |
| Easiair UK Limited | Construction | 2006 |
| East Devon Estates Limited | Real estate | 2012 |
| East European Metals Limited | Information & communication | 2010 |
| East Midlands Therapy Training Ltd | Education | 2024 |
| East Street (Newton Abbot) Management Company Limited | Households | 2023 |
| East YAU Limited | Hospitality | 2024 |
| Eastcliff Court (Teignmouth) Limited | Households | 1985 |
| Eastern Primary Care Collaborative Board Limited | Health & social care | 2025 |
| Eastfield Gundogs Ltd | Agriculture & fishing | 2019 |
| Easy CSP Ltd | Wholesale & retail | 2021 |
| EAT That Frog C.I.C. | Health & social care | 2011 |
| Eatons Poultry Farms Limited | Hospitality | 2000 |
| Ebim Consulting Ltd | Professional & scientific | 2026 |
| Ebim Holdco Ltd | Financial services | 2026 |
| Ebim Property Ltd | Households | 2026 |
| Ecce Fidus Homo Ltd | Real estate | 2010 |
| Eclipse First AID Training Limited | Education | 2013 |
| Eco Green Renewables Devon Limited | Professional & scientific | 2018 |
| Eco Homes (Design & Build) Ltd | Construction | 2018 |
| Ecognosis Ltd | Professional & scientific | 2024 |
| Ecological Intelligence Ltd | Information & communication | 2025 |
| ECU Services Ltd | Professional & scientific | 2019 |
| ECW Logistics Ltd | Transport & logistics | 2016 |
| Edac Limited | Other services | 1998 |
| EDC (SW) Ltd | Health & social care | 2002 |
| Edenwell Apartments Limited | Real estate | 2020 |
| Edge Operations Ltd | Construction | 2026 |
| Edgecraft Studio Limited | Professional & scientific | 2025 |
| Edgemont Construction Limited | Real estate | 1986 |
| Edleigh Construction Ltd | Construction | 2023 |
| Educated Recruitment Limited | Administrative & support | 2013 |
| Edward Griffin Consulting Ltd | Professional & scientific | 2020 |
| Edwards Building Services (SW) Ltd | Construction | 2007 |
| Edwards Fudge Dartmouth Ltd | Wholesale & retail | 2018 |
| Edwards Fudge Kitchen (Brixham) Limited | Wholesale & retail | 2019 |
| Edwards Fudge Kitchen (Totnes) Limited | Wholesale & retail | 2018 |
| Edwards House to Home Properties Ltd | Real estate | 2023 |
| Edwards Properties South West Holdings Ltd | Extraterritorial | 2023 |
| Edwards Property Developments SW Ltd | Construction | 2024 |
| Eems Wave Limited | Administrative & support | 2019 |
| Effaux Investments Limited | Construction | 2006 |
| Effaux Securities Limited | Construction | 2006 |
| Effie Grey Ltd | Wholesale & retail | 2023 |
| Egham Lettings Ltd | Real estate | 2016 |
| Eigenlabs Limited | Professional & scientific | 2001 |
| Eighteen West Limited | Other services | 2018 |
| Ekkist Build Limited | Construction | 2019 |
| EL Jefe Holdings Ltd | Financial services | 2022 |
| Elagler Limited | Wholesale & retail | 2025 |
| Elbury Property Developments Limited | Construction | 2015 |
| Eldern Estates Ltd | Real estate | 2021 |
| Element 5 Limited | Construction | 2005 |
| Element 6 Services Ltd | Wholesale & retail | 2018 |
| Element Architecture Limited | Professional & scientific | 2024 |
| Element DAB Property Ltd | Real estate | 2023 |
| Element Design and Build Ltd | Construction | 2012 |
| Elemental Digest Limited | Water & waste | 2012 |
| Elemental Energy Organisation Ltd | Professional & scientific | 2011 |
| Elforlight Limited | Professional & scientific | 1997 |
| Eliot Design & Build Limited | Construction | 2012 |
| Elisa Becchetti Ltd | Professional & scientific | 2016 |
| Elite Care Devon Ltd | Administrative & support | 2018 |
| Elite Dressage Ltd | Wholesale & retail | 2023 |
| Elko EP UK Limited | Manufacturing | 2020 |