| Elles Tanning & Beauty Ltd | Health & social care | 2015 |
| Elliot Smith Production Lighting Limited | Arts & recreation | 2024 |
| Elliott Court Management Company Limited | Households | 1997 |
| Ellis Engineering Steel Fabrications and Sales Ltd | Manufacturing | 2026 |
| Ellis Express Freight Limited | Transport & logistics | 2004 |
| Ellison Estates Ltd | Real estate | 2024 |
| ELM Kind Ltd | Administrative & support | 2018 |
| ELM Properties (NW) Ltd | Real estate | 2020 |
| Elmorej.Am Ltd | Hospitality | 2015 |
| Elmstar Machinery Ltd | Manufacturing | 2021 |
| Elmtree Accommodation Ltd | Administrative & support | 2025 |
| Elnay Limited | Wholesale & retail | 2011 |
| Elnh Limited | Administrative & support | 2025 |
| Eloise Jephson Ltd | Wholesale & retail | 2021 |
| EMB Electrical Services Ltd | Construction | 2013 |
| Emberglow Living Ltd | Real estate | 2024 |
| EMC Carpentry Ltd | Construction | 2025 |
| Emery Beauty Ltd | Wholesale & retail | 2022 |
| Emery Clinical Ltd | Wholesale & retail | 2018 |
| Empacta International Limited | Professional & scientific | 2021 |
| Emperor Security Services Limited | Administrative & support | 2022 |
| Empire Homes (South West) Limited | Construction | 2015 |
| Empire Properties (South West) Ltd | Real estate | 2022 |
| Empire Removals South West Ltd | Transport & logistics | 2022 |
| Empire Scaffold Limited | Construction | 2015 |
| Empire Wholesale Ltd | Wholesale & retail | 2012 |
| Employment Law Plus (UK) Limited | Professional & scientific | 2010 |
| Enable Group Holdings Ltd | Financial services | 2023 |
| Enable Insurance Services Limited | Financial services | 2015 |
| Enable Investments Ltd | Real estate | 2018 |
| Enable Lettings and Management Ltd | Real estate | 2023 |
| Endohud Limited | Health & social care | 2022 |
| Energy Leap Limited | Professional & scientific | 2025 |
| Enfield Auto Recovery Limited | Administrative & support | 2002 |
| English Riviera Geopark Organisation Ltd | Administrative & support | 2008 |
| Enrish Fernando Ltd | Wholesale & retail | 2023 |
| Entheos Coaching Limited | Other services | 2003 |
| Enviro-Tec SW Ltd | Water & waste | 2019 |
| Environment Matters 247 | Education | 2011 |
| Environmental Drainage Systems Limited | Water & waste | 2020 |
| Environmental Sewage Solutions Limited | Water & waste | 2014 |
| Epieikes Ltd | Financial services | 2025 |
| Epos Consultancy Limited | Information & communication | 2010 |
| EPS Corporate Finance Limited | Professional & scientific | 2008 |
| Equestrian Clearance Sales Online Limited | Wholesale & retail | 2011 |
| Equiost Limited | Professional & scientific | 2015 |
| Equishrooms Limited | Wholesale & retail | 2025 |
| Erase That INK Ltd | Other services | 2022 |
| Erban Consulting Limited | Professional & scientific | 2017 |
| ERC Blade Technician Ltd | Manufacturing | 2026 |
| ERG Car & Van Hire Ltd | Administrative & support | 2025 |
| Erivia Ltd | Real estate | 2024 |
| Erme Clinic Limited | Health & social care | 2025 |
| Essex Skipper Property Management Ltd | Real estate | 2023 |
| Estate Agent Services Ltd | Administrative & support | 2023 |
| Estuary Homes (Topsham) Limited | Real estate | 2011 |
| Estuary Lettings (Topsham) Limited | Real estate | 2010 |
| Estuary View Installations Ltd | Construction | 2020 |
| ESW Solutions Ltd | Arts & recreation | 2024 |
| Etairos Search Ltd | Administrative & support | 2020 |
| Euphoria Glass Ltd | Manufacturing | 2018 |
| EVA - Elite Virtual Assistant Ltd | Administrative & support | 2023 |
| Evalogica Limited | Professional & scientific | 2007 |
| Evans & Co (Plumbing) Ltd | Construction | 2006 |
| Evbug Distribution Ltd | Wholesale & retail | 2015 |
| Event Hire Solutions Limited | Administrative & support | 2005 |
| Evergreen Outdoors Limited | Manufacturing | 2026 |
| Eversley Training Co Ltd | Education | 2025 |
| Everything Adventure Ltd | Education | 2026 |
| Eviqa Ltd | Information & communication | 2026 |
| Evolution Barbers Limited | Other services | 2024 |
| Evolution Green Limited | Other services | 2011 |
| Evolving Forests Ltd | Agriculture & fishing | 2022 |
| Excel Driveways Ltd | Construction | 2012 |
| Excel Shellfish Limited | Manufacturing | 2001 |
| EXE Shipping Limited | Manufacturing | 2010 |
| Exe-Tech Electrical Limited | Construction | 2013 |
| Exeter Agent Services Ltd | Administrative & support | 2026 |
| Exeter High Street Management Ltd | Real estate | 2024 |
| Exeter Lettings LLP | | 2018 |
| Exeter Psychotherapy Ltd | Health & social care | 2024 |
| Exeter Road Garage (Cullompton) Ltd | Wholesale & retail | 2025 |
| Exeter Shopfitting Limited | Construction | 2004 |
| Exim Dance Company C.I.C. | Arts & recreation | 2011 |
| Exit Strategy & Solutions Ltd | Professional & scientific | 2025 |
| Exmouth Indoor Storage Limited | Transport & logistics | 2015 |
| Exonia Property Management Ltd | Administrative & support | 2024 |
| Exprop Ltd | Construction | 2020 |
| Exsf Limited | Financial services | 2012 |
| EYE Help Ltd | Health & social care | 2016 |
| EYE Powered Ltd | Information & communication | 2014 |
| Ezymed Ltd | Public administration | 2024 |
| F Powell Holdings Ltd | Financial services | 2024 |
| F Powell Limited | Health & social care | 2015 |
| F&G Partners Ltd | Professional & scientific | 2022 |
| F.A.C Property Investments Ltd | Real estate | 2025 |
| Fabtech Group Limited | Financial services | 2025 |
| Fairfax Property (South West ) Ltd | Real estate | 2013 |
| Fairfield Carpentry Ltd | Construction | 2025 |
| Fairfield Properties (Bristol) Limited | Real estate | 2001 |