| Devon Fuels Limited | Professional & scientific | 2012 |
| Devon Groundworks Ltd | Construction | 2015 |
| Devon Hand Surgery Limited | Health & social care | 2019 |
| Devon Home Care Limited | Health & social care | 2001 |
| Devon Integrated Social Care Alliance CIC | Health & social care | 2022 |
| Devon Knee Surgery Limited | Health & social care | 2010 |
| Devon Life Celebrations Ltd | Health & social care | 2014 |
| Devon Lifting Services Limited | Construction | 2012 |
| Devon Matters Limited | Information & communication | 2018 |
| Devon Microgreens Ltd | Extraterritorial | 2023 |
| Devon Orthopaedics Limited | Health & social care | 2016 |
| Devon Party Marquees Ltd | Administrative & support | 2010 |
| Devon Renewable Solutions Ltd | Construction | 2022 |
| Devon Security Services Ltd | Administrative & support | 2024 |
| Devon Self-Assessment Ltd | Financial services | 2010 |
| Devon Smart Repair Ltd | Wholesale & retail | 2024 |
| Devon Spice Limited | Hospitality | 2024 |
| Devon Square Charity Accounting Limited | Professional & scientific | 2012 |
| Devon Square Orthodontics Limited | Health & social care | 2007 |
| Devon Tank Replacements Limited | Other services | 2024 |
| Devon Tarmasters (SW) Limited | Professional & scientific | 2008 |
| Devon Wedding Venue Ltd | Hospitality | 2016 |
| Devonia Water Ltd | Manufacturing | 2014 |
| Devonshire Health Consulting Limited | Professional & scientific | 2016 |
| Devonshire Homes (Longston 2) Limited | Construction | 2023 |
| Devonshire Medical & Surgical Services Ltd | Health & social care | 2026 |
| Devonshire Property Limited | Agriculture & fishing | 1998 |
| Dewerstone Digital Ltd | Professional & scientific | 2024 |
| DG Accountants SW Ltd | Professional & scientific | 2024 |
| DGB Randall Ltd | Information & communication | 2012 |
| DH Earthworks (Holdings) Ltd | Financial services | 2025 |
| DH Earthworks Ltd | Construction | 2010 |
| Dhlc (SW) Limited | Professional & scientific | 2025 |
| Diablos Ltd | Hospitality | 2015 |
| Diamond Care (2000) Limited | Health & social care | 2000 |
| Diamond Care Property Holdings Limited | Financial services | 2020 |
| Dickins Castle Limited | Hospitality | 2021 |
| Digital Bookkeeping & Financial Management Ltd | Professional & scientific | 2019 |
| Digital Textile Laboratories PLC | Manufacturing | 2025 |
| Digital Textile Printing Solutions Ltd | Wholesale & retail | 2024 |
| Dinky Holdings Limited | Financial services | 2016 |
| Dinocon UK Ltd | Administrative & support | 2024 |
| Diocesan Trading Limited | Construction | 1990 |
| Dion Tabrett Ltd | Health & social care | 2023 |
| Direct Brand Limited | Wholesale & retail | 2004 |
| Direct Path Ltd | Professional & scientific | 2009 |
| Dirty Dawgs Ltd | Hospitality | 2025 |
| Discs of Gold Ltd | Wholesale & retail | 2017 |
| Ditton Properties Limited | Real estate | 2020 |
| Divine Electrical Services Ltd | Construction | 2026 |
| Dixons Roofing & Leadwork Limited | Construction | 2020 |
| DJ Commercials (SW) Limited | Wholesale & retail | 2024 |
| DJ Commercials Holding Limited | Financial services | 2024 |
| Djma Limited | Professional & scientific | 2015 |
| DJR Developments Builders Limited | Construction | 2026 |
| DK Recruitment Limited | Administrative & support | 2016 |
| DL Kitchen Limited | Hospitality | 2020 |
| DMC Grove Limited | Professional & scientific | 2015 |
| Dockree Property Management Limited | Real estate | 2026 |
| Doclothing Company Limited | Wholesale & retail | 2008 |
| Dog Day (Devon) Limited | Other services | 2013 |
| Dolbear's Garage Limited | Wholesale & retail | 2006 |
| Dolphin Steel Ltd | Wholesale & retail | 2025 |
| Domystuff Ltd | Administrative & support | 2020 |
| Donkey Works Ltd | Wholesale & retail | 2016 |
| Doorstuff Limited | Wholesale & retail | 2006 |
| Doran Contractors Limited | Construction | 2016 |
| Dormant Music Limited | Arts & recreation | 1978 |
| Douch Developments Ltd | Wholesale & retail | 2004 |
| Doug Williamson Healthcare Ltd | Health & social care | 2015 |
| Dovetail Fire Doors Ltd | Public administration | 2025 |
| Dpfdr Ltd | Wholesale & retail | 2024 |
| DPJ Groups Ltd | Construction | 2019 |
| DPJ Property 2 Ltd | Real estate | 2019 |
| DPJ Property 3 Limited | Real estate | 2019 |
| DPJ Property Ltd | Construction | 2017 |
| DPP2019 Limited | Financial services | 2019 |
| DPP3 Limited | Financial services | 2007 |
| DR GUY Gribbin Ltd | Health & social care | 2019 |
| Dr.Andrei.Corrects Ltd | Health & social care | 2021 |
| Dragon Autobodies Ltd | Wholesale & retail | 2024 |
| Dragon Drift Ltd | Wholesale & retail | 2026 |
| Dragon Storage Solutions Ltd | Transport & logistics | 2026 |
| Drait Shipping Limited | Administrative & support | 2022 |
| Drakewalls Marketing Limited | Professional & scientific | 2025 |
| Dramquest Limited | | 1983 |
| Dream K&S Ltd | Real estate | 2022 |
| Drew & Sons Funeral Directors Ltd | Other services | 2013 |
| Drew & Sons Plant Hire Limited | Construction | 1995 |
| Drew & Sons Property and Lettings LLP | | 2022 |
| Drew Pearce 1748 Limited | Professional & scientific | 2013 |
| Drew Property Services Limited | Real estate | 2017 |
| Drew's House Ltd | Wholesale & retail | 2018 |
| Driftwood Properties Limited | Real estate | 2009 |
| Drive Control Ltd | Information & communication | 2002 |
| Druid Mine Limited | Agriculture & fishing | 2025 |
| Drytech Roofing Ltd | Construction | 2021 |
| DS Landscapes and Driveways Ltd | Administrative & support | 2026 |
| DS Prosthetics Limited | Health & social care | 2015 |
| DSB Plumbing & Heating Limited | Construction | 2015 |