| Shield Tech Security Limited | Administrative & support | 2018 |
| Shields Road PUB Co Limited | Hospitality | 2013 |
| Shiftspan Ltd | Information & communication | 2025 |
| Shimna Consulting Ltd | Professional & scientific | 2015 |
| Shimna Estates Ltd | Real estate | 2023 |
| Shimna Integrated College Limited | Education | 1994 |
| Shimna Taxis Ltd | Transport & logistics | 2018 |
| Shipncare Ltd | Transport & logistics | 2023 |
| Shipton Projects Limited | Construction | 2024 |
| SHK Accountants Limited | Professional & scientific | 1999 |
| SHK Secretary Limited | Administrative & support | 2003 |
| Shmatte Ltd | Wholesale & retail | 2026 |
| Shoot My Product Ltd | Professional & scientific | 2022 |
| Shopimax Online Ltd | Wholesale & retail | 2024 |
| Shorewest Properties Ltd | Real estate | 2020 |
| Shortbite Bakery Limited | Manufacturing | 2026 |
| Shotoclock Ltd | Hospitality | 2025 |
| Showhome Properties Limited | Real estate | 1994 |
| Shri Ayodhya Medical Services Limited | Health & social care | 2012 |
| Shrigley Consulting Limited | Information & communication | 2006 |
| Shuffle Homes Ltd | Real estate | 2022 |
| Shute Medcare Ltd | Health & social care | 2022 |
| Siammk Limited | Wholesale & retail | 2025 |
| SID Recruitment Limited | Administrative & support | 2020 |
| Sidebyside Nursery Limited | Health & social care | 2019 |
| Sigma AI Limited | Information & communication | 2022 |
| Signature 2008 Ltd | Other services | 2024 |
| Signature Developments Staffordshire Ltd | Manufacturing | 2026 |
| Signature Kitchens, Bathrooms and Tiles Ltd | Wholesale & retail | 2013 |
| Signature Learning Limited | Administrative & support | 2010 |
| Silver FOX Taverns Limited | Arts & recreation | 2018 |
| Silver Linings Industrial Solutions Ltd | Manufacturing | 2026 |
| Silver Stairlifts Ltd | Extraterritorial | 2010 |
| Silver Star Motors Ltd | Wholesale & retail | 2023 |
| Silver Style Trade Ltd | Manufacturing | 2019 |
| Silverdale Bathrooms Limited | Manufacturing | 2014 |
| Silvermill Lettings Ltd | Real estate | 2024 |
| Silverstar Property Group Ltd | Construction | 2018 |
| Silverstream Holdings Ltd | Financial services | 2025 |
| Silvertree Cleaning Support Ltd | Administrative & support | 2013 |
| Silvertree Property Investments Ltd | Real estate | 2024 |
| Simon Tagg (STL) Ltd | Information & communication | 2011 |
| Simple Life (Alsager) Limited | Administrative & support | 2011 |
| Simply Katy Ltd | Wholesale & retail | 2020 |
| Simply Maintenance (Alsager) Limited | Administrative & support | 2022 |
| Simply Tax (2018) Ltd | Professional & scientific | 2018 |
| Simply Thai Cuisine Ltd | Hospitality | 2017 |
| Simpson & Wilde Independent Funeral Directors Limited | Other services | 2020 |
| Singh’S NCL Traders Limited | Wholesale & retail | 2026 |
| Sita Pamoja Limited | Real estate | 2023 |
| Site Pro-Tech Ltd | Manufacturing | 2014 |
| Sixcove Limited | Real estate | 1996 |
| SJB Construction (NI) Ltd | Construction | 2018 |
| SJB Stanley Limited | Wholesale & retail | 2010 |
| SJS Construction Ltd | Construction | 2016 |
| SJS Developments Ltd | Real estate | 2020 |
| SJS Groundworks & Civils Limited | Construction | 2020 |
| Skill Q Limited | Information & communication | 2018 |
| Skillsbite Ltd | Information & communication | 2021 |
| Skinny Foods Concepts Ltd | Wholesale & retail | 2013 |
| Sky Blue Structures Limited | Construction | 2012 |
| Sky Property Lettings Ltd | Real estate | 2020 |
| Sky Property Ltd | Real estate | 2019 |
| Slater Developments Limited | Real estate | 2019 |
| Slater Mechanical Ltd | Construction | 2026 |
| Slater Plumbing and Heating Limited | Construction | 2019 |
| Slaters & Co Accountants Limited | Professional & scientific | 2015 |
| Slieve Commedagh Clinic Limited | Health & social care | 2024 |
| Slievenaman Goat Trail and Petting Farm Ltd | Arts & recreation | 2024 |
| Slim SOL Ltd | Wholesale & retail | 2023 |
| SLM Hairdressing Ltd | Other services | 2012 |
| SM Design Property Limited | Real estate | 2020 |
| Small's Butchers & Deli Ltd | Wholesale & retail | 2016 |
| Smart GAS Heating Ltd | Construction | 2019 |
| Smart Home Systems Limited | Wholesale & retail | 2025 |
| Smart School Uniform Ltd | Extraterritorial | 2014 |
| Smart Virtual Assistant Ltd | Administrative & support | 2020 |
| Smarter Recruitment Consultancy Ltd | Administrative & support | 2024 |
| Smarties Consulting Ltd | Professional & scientific | 2024 |
| Smash Castle Ltd | Hospitality | 2025 |
| SMG Consultancy Services Limited | Professional & scientific | 2016 |
| Smipa Ltd | Professional & scientific | 2024 |
| Smoothly Driven Logistics Ltd | Transport & logistics | 2020 |
| SMS Plumbing Services Limited | Construction | 2007 |
| Smurph Engineering Limited | Manufacturing | 2018 |
| Smurph Skip Hire Ltd | Water & waste | 2025 |
| SN Breast Clinic Limited | Health & social care | 2022 |
| Snape Group Consulting Ltd | Administrative & support | 2024 |
| Sneaky Culture Ltd | Wholesale & retail | 2009 |
| Snuffelupagus Ltd | Other services | 2022 |
| Soak Seaweed Baths Ltd | Other services | 2011 |
| Social Proof Ltd | Information & communication | 2020 |
| Solar Loop Ltd | Construction | 2021 |
| Solden Systems Ltd. | Information & communication | 2025 |
| Solid State Software Ltd | Information & communication | 2025 |
| Solidstone Surfacing Ltd | Construction | 2025 |
| Solo Pizza Margherita Ltd | Hospitality | 2025 |
| Solumetics Ltd | Wholesale & retail | 2019 |
| Sonderadvice Ltd | Professional & scientific | 2016 |
| Sorica Ltd | Transport & logistics | 2020 |