| Safepark App Ltd | Transport & logistics | 2024 |
| Safepippin Compliance Ltd | Professional & scientific | 2026 |
| Safety Gear Store Ltd | Wholesale & retail | 2010 |
| Safety Systems Distribution Limited | Construction | 1998 |
| Safevancourier Ltd | Transport & logistics | 2019 |
| Saffron Financial Solutions Ltd | Professional & scientific | 2026 |
| Saha Stores Ltd | Wholesale & retail | 2019 |
| SAI RAM Medicals Limited | Health & social care | 2013 |
| Salam Investment Group Ltd | Real estate | 2025 |
| Salebizpro Ltd | Wholesale & retail | 2025 |
| Sales Geek Cheshire East Limited | Administrative & support | 2021 |
| Sales Surge Enterprise Limited | Wholesale & retail | 2025 |
| Salevex Holdings Ltd | Financial services | 2026 |
| Salevex Property Ltd | Real estate | 2026 |
| Salman Mobile Hub Ltd | Wholesale & retail | 2025 |
| Salon G Limited | Other services | 2018 |
| Salon GMA Limited | Other services | 2015 |
| Samaro Properties Limited | Real estate | 2023 |
| Samrat Newcastle Under Lyme Limited | Hospitality | 2025 |
| Samsonite Investments Limited | Financial services | 2020 |
| Samuel Hobson House Limited | Health & social care | 2019 |
| Sand Residential Ltd | Construction | 2026 |
| Sanderson Joinery Manufacturing Limited | Manufacturing | 2008 |
| Sandown Developments Ltd | Construction | 2020 |
| Saporium Limited | Administrative & support | 2023 |
| Saraj Medical Ltd | Hospitality | 2014 |
| Saratov Systems Ltd | Public administration | 2026 |
| Sarav Group Limited | Wholesale & retail | 2024 |
| Sarcel 2015 Ltd | Transport & logistics | 2026 |
| Sarnel Pubs Ltd | Hospitality | 2024 |
| SAS E-Commerce Ltd | Information & communication | 2023 |
| Sasco International Ltd | Transport & logistics | 2018 |
| Satori Education Limited | Information & communication | 2018 |
| Sauna Ice Balance Ltd | Other services | 2024 |
| Savage Industries Ltd | Wholesale & retail | 2025 |
| Sayturk Capital Limited | Real estate | 2024 |
| SB Electrics Limited | Construction | 2003 |
| SB Events H-Vac Ltd | Construction | 2025 |
| SB Supply Ltd | Manufacturing | 2026 |
| SBS Touring and Management Ltd | Arts & recreation | 2026 |
| Sbyte Ltd | Information & communication | 2018 |
| SCA Homes Ltd | Real estate | 2025 |
| Scaled Thinking Ltd | Information & communication | 2025 |
| SCB 2019 Ltd | Construction | 2019 |
| Schott Industrial Glass Limited | Manufacturing | 1979 |
| Scissor Sisters (Sunniside) Ltd | Other services | 2022 |
| Scone - Tea Party Catering Limited | Hospitality | 2021 |
| Scoreboard Sports Limited | Arts & recreation | 2025 |
| Scotbey Holdings Ltd | Households | 2025 |
| Scott Accounting Services Ltd | Professional & scientific | 2004 |
| Scott Mills Joinery Ltd | Construction | 2014 |
| Scragg Power Limited | Energy | 2013 |
| SCS Staffs Ltd | Wholesale & retail | 2017 |
| SDW Valeting Limited | Other services | 2003 |
| Sea Palace Newcastle Ltd | Hospitality | 2024 |
| Seabridge Care Club Ltd | Health & social care | 2023 |
| Seaforde Management Company Limited | Households | 2024 |
| Seamus Delaney Law Ltd | Professional & scientific | 2023 |
| Seaplus Logistics Limited | Transport & logistics | 2026 |
| Seaton Developments Limited | Real estate | 2002 |
| Seaton Leisure Properties Limited | Real estate | 2006 |
| Seaton Rest Homes Limited | Real estate | 1965 |
| Second Skin Studio Ltd | Wholesale & retail | 2020 |
| Securifab Limited | Professional & scientific | 2018 |
| Sedohr Project Solutions Ltd | Professional & scientific | 2015 |
| Select Car Credit Ltd | Wholesale & retail | 2020 |
| Selfback Ltd | Health & social care | 2021 |
| Semantic Clarity Limited | Information & communication | 2008 |
| SEN Reform NI Ltd | Education | 2023 |
| Senor Co Limited | Extraterritorial | 2023 |
| Sensory Arts and Music School Ltd | Education | 2023 |
| SEO Master Ltd | Wholesale & retail | 2026 |
| Serendipity Newcastle Limited | Wholesale & retail | 2019 |
| Serlex Ltd | Professional & scientific | 2017 |
| Seropian Ltd | Construction | 2019 |
| Sevek Ltd | Administrative & support | 2024 |
| Sews Distribution Limited | Transport & logistics | 2025 |
| SFT Homes Ltd | Real estate | 2025 |
| SG Developments (Staffs) Ltd | Extraterritorial | 2025 |
| SG Recovery Ltd | Transport & logistics | 2025 |
| SGB World Services Limited | Construction | 2002 |
| SGC Venture Group Ltd | Wholesale & retail | 2026 |
| Shaf Property Investments Ltd | Real estate | 2023 |
| Shafik S Consultancy Ltd | Professional & scientific | 2020 |
| Shake That Weight Ltd | Wholesale & retail | 2013 |
| Shakenpatty Limited | Hospitality | 2019 |
| Shallcross Woodturning Limited | Manufacturing | 2002 |
| Shambhkubera Limited | Financial services | 2026 |
| Shambhrudra Limited | Information & communication | 2026 |
| Sharmonz Ltd | Hospitality | 2017 |
| Shaun Spooner Autos Limited | Wholesale & retail | 2014 |
| Shaw Properties Staffordshire Ltd | Real estate | 2024 |
| Sheer Assets Hansa Ltd | Real estate | 2023 |
| Sheer Assets Ltd | Real estate | 2021 |
| Sheer Assets Shiva Ltd | Real estate | 2025 |
| Sheer Iron Market Limited | Administrative & support | 2025 |
| Shelby Vape Ltd | Wholesale & retail | 2026 |
| Shepland Creative Ltd | Other services | 2024 |
| Sherlock Homes Property Maintenance Ltd | Real estate | 2019 |
| Sherwood Consultants Ltd | Professional & scientific | 2020 |