| Duggie Medical Services Ltd | Health & social care | 2018 |
| DUK NE Ltd | Real estate | 2025 |
| Dukawholesale Ltd | Wholesale & retail | 2026 |
| Dukes Meadow Management Company Ncle Limited | Households | 2009 |
| Dumi Construction Ltd | Construction | 2018 |
| Dumitrucourier Ltd | Transport & logistics | 2025 |
| Dunamis 247 Limited | Real estate | 2016 |
| Duncan Rockett Associates Limited | Health & social care | 2002 |
| Duncan Turner Limited | Wholesale & retail | 2001 |
| Duncansby NE Limited | Real estate | 2017 |
| Dunelm Management Company Limited | Households | 2004 |
| Dunelm Retails Ltd | Wholesale & retail | 2020 |
| Dunemoor Ltd | Manufacturing | 2025 |
| Dunholm Leadership Academy Ltd | Professional & scientific | 2025 |
| Dunholm Ventures Limited | Financial services | 2025 |
| Dunlavy Builders Ltd | Construction | 2014 |
| Dunlavy Construction Managment Ltd | Construction | 2019 |
| Dunnington and Strensall Group Practice Limited | Financial services | 2017 |
| Dunn’S Lettings (Newcastle) Ltd | Real estate | 2024 |
| Dunroamin Properties Limited | Real estate | 2011 |
| Dunston Car Centre Limited | Administrative & support | 2011 |
| Dunston D.I.Y Centre Ltd | Wholesale & retail | 2021 |
| Dunston Services Ltd | Information & communication | 2023 |
| Dunwoodie Swift Architects Limited | Professional & scientific | 2022 |
| Dura Cleaning Services Ltd | Administrative & support | 2019 |
| Durham Businesswear Limited | Extraterritorial | 2018 |
| Durham Care Line Limited | Health & social care | 1986 |
| Durham CEC Limited | Wholesale & retail | 2022 |
| Durham City Association Football Club Limited | Arts & recreation | 2002 |
| Durham County Show Limited | Arts & recreation | 2019 |
| Durham Global Research Group Ltd | Professional & scientific | 2025 |
| Durham Hotels Limited | Hospitality | 2025 |
| Durham Inns Holdings Company Limited | Hospitality | 2004 |
| Durham Inns Limited | Extraterritorial | 2004 |
| Durham Muslims Community | Education | 2022 |
| Durham Show Limited | Arts & recreation | 2019 |
| Durham Vale Developments Limited | Extraterritorial | 2005 |
| Dust and Shine Limited | Administrative & support | 2025 |
| Dutch Hatch Ltd | Wholesale & retail | 2025 |
| Duttoni Investment Holdings Limited | Real estate | 2024 |
| Dvno SPV 1 Limited | Real estate | 2026 |
| Dvsc Services Ltd | Professional & scientific | 2026 |
| DW Diagnostics Limited | Wholesale & retail | 2019 |
| DW Motorworks Limited | Wholesale & retail | 2016 |
| DW Wealth Management Ltd | Financial services | 2014 |
| DWA Properties Limited | Real estate | 2023 |
| DWC Northumberland Ltd | Hospitality | 2026 |
| DWCN1 Limited | Financial services | 2017 |
| Dwelling Property Services Limited | Real estate | 2012 |
| DWG Environment & Health Limited | Professional & scientific | 2022 |
| Dwne Ltd | Information & communication | 2023 |
| Dwrfa Limited | Health & social care | 2022 |
| Dxcr Limited | Hospitality | 2024 |
| DY Training Ltd | Education | 2021 |
| Dykefield Avenue 1965 Limited | Extraterritorial | 2014 |
| Dynabite Limited | Hospitality | 2021 |
| Dynamic Aggregate Ltd | Wholesale & retail | 2025 |
| Dynamic Automation Limited | Manufacturing | 2002 |
| Dynamic Building & Construction Ltd | Construction | 2025 |
| Dynamic Draught Beverage Services Ltd | Other services | 2026 |
| Dynamic Fitness NCL Ltd | Health & social care | 2025 |
| Dynamic Integrated Services Ltd | Professional & scientific | 2015 |
| Dynamic Marine Ltd | Professional & scientific | 2018 |
| Dynamic NE Limited | Wholesale & retail | 2014 |
| Dynamic Path Ventures Ltd | Professional & scientific | 2024 |
| Dynamic Plant Hire Ltd | Administrative & support | 2025 |
| Dynamite Hosts and Events Limited | Other services | 2008 |
| Dynamite Pink Ltd | Arts & recreation | 2009 |
| Dynamo North East C.I.C. | Information & communication | 2014 |
| Dyslexit Limited | Information & communication | 2026 |
| DZ Environmental & Training Limited | Professional & scientific | 2013 |
| E & C HO Limited | Wholesale & retail | 2005 |
| E & F Composites Limited | Manufacturing | 1985 |
| E & I Services Ltd | Professional & scientific | 2026 |
| E a Miller Limited | Wholesale & retail | 2023 |
| E C L (2000) Limited | Construction | 2009 |
| E Khosla Ltd | Health & social care | 2022 |
| E M D Psychiatric Consulting Ltd | Health & social care | 2020 |
| E Milner Hair Ltd | Other services | 2021 |
| E Property Invest Ltd | Real estate | 2020 |
| E&A Holding Limited | Real estate | 2019 |
| E&E Letting Ltd | Real estate | 2019 |
| E&L Capital Limited | Administrative & support | 2015 |
| E&M Entertainment Ltd | Other services | 2023 |
| E&R Joinery Contractors Limited | Construction | 2018 |
| E&S Property Management Ltd | Real estate | 2017 |
| E-Core Group Ltd | Professional & scientific | 2023 |
| E-Core Mechanical & Electrical Ltd | Construction | 2023 |
| E. & C. Blake Ltd | Wholesale & retail | 2023 |
| E. Dixon & J. Thompson Limited | Construction | 2004 |
| E. J. Stone Limited | Real estate | 2001 |
| E. Stanley Engineering (Tyne & Wear) Limited | | 1978 |
| E.Crawford Limited | | 1962 |
| E.D. Nunnerley Limited | Construction | 2005 |
| E.G.E Hall Opticians Limited | Wholesale & retail | 2002 |
| E.J.Melling Limited | Wholesale & retail | 1961 |
| E.L.M Leisure Enterprises Ltd | Arts & recreation | 2023 |
| E.L.M North East Ltd | Real estate | 2026 |
| E.P.Robinson Limited | Wholesale & retail | 1958 |
| E2NETZERO LLP | | 2022 |